Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer

The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction

(2021) Jennifer E. Klomp et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Combined Blockade of the MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma

(2021) Brent A. Willobee et al.   MOLECULAR CANCER THERAPEUTICS

Estimated Projection of US Cancer Incidence and Death to 2040

(2021) Lola Rahib et al.   JAMA Network Open

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

(2021) Kevin Freeman-Cook et al.   CANCER CELL

Sotorasib: First Approval

(2021) Hannah A. Blair   DRUGS

The pancreatic cancer genome revisited

(2021) Akimasa Hayashi et al.   Nature Reviews Gastroenterology & Hepatology

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

(2021) Andrew M. Waters et al.   Cell Reports

The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer

(2021) J. Nathaniel Diehl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

(2021) Jennifer E. Klomp et al.   Cell Reports

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

(2020) Kevin H. Lin et al.   NATURE GENETICS

Quantifying CDK inhibitor selectivity in live cells

(2020) Carrow I. Wells et al.   Nature Communications

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

(2020) Irem Ozkan-Dagliyan et al.   Cell Reports

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions

(2020) Rose Oughtred et al.   PROTEIN SCIENCE

Functional determinants of cell-cycle plasticity and sensitivity to CDK4/6 inhibition

(2020) Vishnu Kumarasamy et al.   CANCER RESEARCH

Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma

(2020) Francesca Ida Montalto et al.   Cells

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

(2019) Kirsten L. Bryant et al.   NATURE MEDICINE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies

(2019) Kevin Lou et al.   Science Signaling

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Targeting CDK2 in cancer: challenges and opportunities for therapy

(2019) Solomon Tadesse et al.   DRUG DISCOVERY TODAY

FBXW7: a critical tumor suppressor of human cancers

(2018) Chien-Hung Yeh et al.   Molecular Cancer

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

(2018) Natalia Martinez-Soria et al.   CANCER CELL

Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes

(2018) Andrew McGuigan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors

(2018) Francesco Schettini et al.   Frontiers in Oncology

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

(2017) Míriam Tarrado‐Castellarnau et al.   Molecular Systems Biology

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

(2017) Andrew M. Waters et al.   Cold Spring Harbor Perspectives in Medicine

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

(2016) Tikvah K. Hayes et al.   CANCER CELL

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth

(2016) Xiangnan Guan et al.   MOLECULAR CANCER RESEARCH

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities

(2016) Jorge Franco et al.   Cell Reports

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

(2015) B. W. Murray et al.   MOLECULAR CANCER THERAPEUTICS

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

(2015) Agnieszka K. Witkiewicz et al.   Oncotarget

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

(2015) Jorge Franco et al.   Oncotarget

Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2

(2014) Yun-Han Lee et al.   CANCER RESEARCH

CDK4/6 and IGF1 Receptor Inhibitors Synergize to Suppress the Growth of p16INK4A-Deficient Pancreatic Cancers

(2014) A. M. Heilmann et al.   CANCER RESEARCH

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures

(2013) Giulia Federici et al.   MOLECULAR CANCER RESEARCH

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Cdk4/6 Inhibition Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness in Pancreatic Cancer Cells

(2012) F. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Compensatory Pathways in Oncogenic Kinase Signaling and Resistance to Targeted Therapies: Six Degrees of Separation: Figure 1.

(2012) Livio Trusolino et al.   Cancer Discovery

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

(2009) Elsa-Noah N'Diaye et al.   EMBO REPORTS

Statistical methods for analysis of high-throughput RNA interference screens

(2009) Amanda Birmingham et al.   NATURE METHODS