Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and Stroma

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs

(2020) Jinhui Lü et al.   CLINICAL SCIENCE

Hypomethylation of the cyclin D1 promoter in hepatitis B virus-associated hepatocellular carcinoma

(2020) Hui-Hui Liu et al.   MEDICINE

CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors

(2020) Yu Chen et al.   Frontiers in Immunology

The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment

(2020) Saveria Aquila et al.   Cells

The membrane-associated form of cyclin D1 enhances cellular invasion

(2020) Ke Chen et al.   Oncogenesis

Cytoplasmic cyclin D1 regulates glioblastoma dissemination

(2019) Tània Cemeli et al.   JOURNAL OF PATHOLOGY

Amplification of the EGFR and CCND1 Are Coordinated and Play Important Roles in the Progression of Oral Squamous Cell Carcinomas

(2019) Huei-Tzu Chien et al.   Cancers

Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation

(2019) Francesca Ida Montalto et al.   Cancers

AIB1 sequestration by androgen receptor inhibits estrogen-dependent cyclin D1 expression in breast cancer cells

(2019) Francesca De Amicis et al.   BMC CANCER

The double dealing of cyclin D1

(2019) Guergana Tchakarska et al.   CELL CYCLE

Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system

(2018) Shan-Ying Wu et al.   HEPATOLOGY

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer

(2018) Chrysiis Michaloglou et al.   MOLECULAR CANCER THERAPEUTICS

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome

(2018) Guangxue Wang et al.   Theranostics

Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics

(2018) Kaixi Tang et al.   PLoS Computational Biology

Cyclin D1 overexpression induces global transcriptional downregulation in lymphoid neoplasms

(2018) Robert Albero et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclin D1 silencing impairs DNA double strand break repair, sensitizes BRCA1 wildtype ovarian cancer cells to olaparib

(2018) Qian Zhong et al.   GYNECOLOGIC ONCOLOGY

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

(2017) Timothy G. Pestell et al.   Oncotarget

Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells

(2017) Wei Xia et al.   Oncotarget

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells

(2017) Simon Body et al.   Scientific Reports

Global trends and predictions in ovarian cancer mortality

(2016) M. Malvezzi et al.   ANNALS OF ONCOLOGY

Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer

(2016) Doireann P. Joyce et al.   INTERNATIONAL JOURNAL OF CANCER

Cyclin D1, cancer progression, and opportunities in cancer treatment

(2016) Shuo Qie et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin

(2016) Noel P. Fusté et al.   Nature Communications

Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer

(2016) Noel P. Fusté et al.   Oncotarget

Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation

(2016) Sushama Kamarajugadda et al.   Oncotarget

Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer

(2015) Francisco Beca et al.   BMC CANCER

Estrogen receptor-α drives adiponectin effects on cyclin D1 expression in breast cancer cells

(2015) Loredana Mauro et al.   FASEB JOURNAL

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

(2015) Richard S Finn et al.   LANCET ONCOLOGY

miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6

(2015) Bairong Xia et al.   Molecular Cancer

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway

(2015) J Chen et al.   ONCOGENE

Association of CCND1 overexpression with KRAS and PTEN alterations in specific subtypes of non-small cell lung carcinoma and its influence on patients’ outcome

(2015) Miodrag Dragoj et al.   TUMOR BIOLOGY

Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer

(2014) JING LI et al.   Oncology Letters

CCND1 amplification and cyclin D1 immunohistochemical expression in head and neck squamous cell carcinomas

(2013) Henning Hanken et al.   Clinical Oral Investigations

Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer

(2013) Zuoren Yu et al.   Nature Communications

Prx I Suppresses K-ras-Driven Lung Tumorigenesis by Opposing Redox-Sensitive ERK/Cyclin D1 Pathway

(2012) Young-Ho Park et al.   ANTIOXIDANTS & REDOX SIGNALING

Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

(2012) T. E. Hickey et al.   MOLECULAR ENDOCRINOLOGY

MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes

(2011) Clemens L. Bockmeyer et al.   BREAST CANCER RESEARCH AND TREATMENT

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Cyclin D1 and Cdk4 Mediate Development of Neurologically Destructive Oligodendroglioma

(2011) D. Ciznadija et al.   CANCER RESEARCH

PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

(2011) Hui Meng et al.   CELL CYCLE

Cyclin D1 Is a Selective Modifier of Androgen-dependent Signaling and Androgen Receptor Function

(2011) Clay E. S. Comstock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

(2010) Z. Zhong et al.   CANCER RESEARCH

Cyclin-Dependent Kinase 4–Mediated Phosphorylation Inhibits Smad3 Activity in Cyclin D–Overexpressing Breast Cancer Cells

(2010) Stanislav Zelivianski et al.   MOLECULAR CANCER RESEARCH

Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen

(2010) Frédéric Bienvenu et al.   NATURE

Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element

(2010) M. Lanzino et al.   NUCLEIC ACIDS RESEARCH

Reducing MCM levels in human primary T cells during the G0→G1 transition causes genomic instability during the first cell cycle

(2010) S J Orr et al.   ONCOGENE

Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

(2009) S. Landskroner-Eiger et al.   CLINICAL CANCER RESEARCH

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Role of Cyclin D1 as a Mediator of c-Met- and  -Catenin-Induced Hepatocarcinogenesis

(2008) M. A. Patil et al.   CANCER RESEARCH

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

(2008) Zuoren Yu et al.   JOURNAL OF CELL BIOLOGY