Mechanistic modeling, simulation, and optimization of mixed‐mode chromatography for an antibody polishing step

Opportunities and challenges for model utilization in the biopharmaceutical industry: current versus future state

(2022) Deenesh K Babi et al.   Current Opinion in Chemical Engineering

In silico process characterization for biopharmaceutical development following the quality by design concept

(2021) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach

(2021) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model

(2021) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Robust mechanistic modeling of protein ion-exchange chromatography

(2021) Vijesh Kumar et al.   JOURNAL OF CHROMATOGRAPHY A

Straightforward method for calibration of mechanistic cation exchange chromatography models for industrial applications

(2020) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Toward in silico CMC: An industrial collaborative approach to model‐based process development

(2020) David Roush et al.   BIOTECHNOLOGY AND BIOENGINEERING

Good modeling practice for industrial chromatography: Mechanistic modeling of ion exchange chromatography of a bispecific antibody

(2019) Federico Rischawy et al.   COMPUTERS & CHEMICAL ENGINEERING

Domain contributions to antibody retention in multimodal chromatography systems

(2018) Julie Robinson et al.   JOURNAL OF CHROMATOGRAPHY A

Multimodal Chromatography for Purification of Biotherapeutics – A Review

(2018) Vivek Halan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Prediction uncertainty assessment of chromatography models using Bayesian inference

(2018) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

A versatile noninvasive method for adsorber quantification in batch and column chromatography based on the ionic capacity

(2016) Thiemo C. Huuk et al.   BIOTECHNOLOGY PROGRESS

Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography

(2016) Gang Wang et al.   JOURNAL OF CHROMATOGRAPHY A

UV absorption-based inverse modeling of protein chromatography

(2015) Tobias Hahn et al.   ENGINEERING IN LIFE SCIENCES

Simulating and Optimizing Preparative Protein Chromatography with ChromX

(2015) Tobias Hahn et al.   JOURNAL OF CHEMICAL EDUCATION

Modeling of dual gradient elution in ion exchange and mixed-mode chromatography

(2015) Yi Feng Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Methods development in multimodal chromatography with mobile phase modifiers using the steric mass action model

(2013) Hanne Sophie Karkov et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluation of selectivity in multimodal anion exchange systems: A priori prediction of protein retention and examination of mobile phase modifier effects

(2011) Ying Hou et al.   JOURNAL OF CHROMATOGRAPHY A

Application of mixed mode resins for the purification of antibodies

(2010) Agnes Voitl et al.   JOURNAL OF CHROMATOGRAPHY A

High-throughput isotherm determination and thermodynamic modeling of protein adsorption on mixed mode adsorbents

(2010) Beckley K. Nfor et al.   JOURNAL OF CHROMATOGRAPHY A

Application of a pH responsive multimodal hydrophobic interaction chromatography medium for the analysis of glycosylated proteins

(2010) K. Kallberg et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluation of protein adsorption and preferred binding regions in multimodal chromatography using NMR

(2010) W. K. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Review of the Thermodynamics of Protein Association to Ligands, Protein Adsorption, and Adsorption Isotherms

(2008) J. M. Mollerup   CHEMICAL ENGINEERING & TECHNOLOGY