Robust mechanistic modeling of protein ion-exchange chromatography

Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach

(2021) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Estimating and leveraging protein diffusion on ion-exchange resin surfaces

(2020) Ohnmar Khanal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship between HETP measurements and breakthrough curves in short chromatography columns

(2020) Joey A. Roberts et al.   BIOTECHNOLOGY PROGRESS

Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing

(2020) Jens Smiatek et al.   TRENDS IN BIOTECHNOLOGY

Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics

(2020) Vijesh Kumar et al.   Annual Review of Chemical and Biomolecular Engineering

Cross‐scale quality assessment of a mechanistic cation exchange chromatography model

(2020) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Good modeling practice for industrial chromatography: Mechanistic modeling of ion exchange chromatography of a bispecific antibody

(2019) Federico Rischawy et al.   COMPUTERS & CHEMICAL ENGINEERING

Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads

(2018) Arch Creasy et al.   Biotechnology Journal

Chromatography Analysis and Design Toolkit (CADET)

(2018) Samuel Leweke et al.   COMPUTERS & CHEMICAL ENGINEERING

Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads

(2018) Arch Creasy et al.   Biotechnology Journal

Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies

(2018) Ohnmar Khanal et al.   JOURNAL OF CHROMATOGRAPHY A

Multiscale modeling and simulations of protein adsorption: progresses and perspectives

(2018) Xuebo Quan et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Ionic strength-dependent changes in tentacular ion exchangers with variable ligand density. II. Functional properties

(2017) Rahul Bhambure et al.   JOURNAL OF CHROMATOGRAPHY A

Multi-state steric mass action model and case study on complex high loading behavior of mAb on ion exchange tentacle resin

(2017) Juliane Diedrich et al.   JOURNAL OF CHROMATOGRAPHY A

Current challenges and future prospects in chromatographic method development for pharmaceutical research

(2017) Frederick T. Mattrey et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Mechanistic Modeling Based PAT Implementation for Ion-Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products

(2017) Vijesh Kumar et al.   Biotechnology Journal

Protein adsorption on ion exchange resins and monoclonal antibody charge variant modulation

(2016) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Combined Yamamoto approach for simultaneous estimation of adsorption isotherm and kinetic parameters in ion-exchange chromatography

(2015) Matthias Rüdt et al.   JOURNAL OF CHROMATOGRAPHY A

Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products

(2015) Vijesh Kumar et al.   JOURNAL OF CHROMATOGRAPHY A

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

The langmuir isotherm: A commonly applied but misleading approach for the analysis of protein adsorption behavior

(2014) Robert A. Latour   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Purifying biopharmaceuticals: knowledge-based chromatographic process development

(2014) Alexander T. Hanke et al.   TRENDS IN BIOTECHNOLOGY

Moment based weighted residual method—New numerical tool for a nonlinear multicomponent chromatographic general rate model

(2013) Zheng Liu et al.   COMPUTERS & CHEMICAL ENGINEERING

Effects of uncertainties in experimental conditions on the estimation of adsorption model parameters in preparative chromatography

(2013) Niklas Borg et al.   COMPUTERS & CHEMICAL ENGINEERING

Modeling of salt and pH gradient elution in ion-exchange chromatography

(2013) Michael Schmidt et al.   JOURNAL OF SEPARATION SCIENCE

Determination of parameters for the steric mass action model—A comparison between two approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography

(2012) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Shrinking-core modeling of binary chromatographic breakthrough

(2011) Steven J. Traylor et al.   JOURNAL OF CHROMATOGRAPHY A

A fast and accurate solver for the general rate model of column liquid chromatography

(2010) Eric von Lieres et al.   COMPUTERS & CHEMICAL ENGINEERING

Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

(2010) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Binary adsorption of globular proteins on ion-exchange media

(2009) Xuankuo Xu et al.   JOURNAL OF CHROMATOGRAPHY A

Protein adsorption and transport in agarose and dextran-grafted agarose media for ion exchange chromatography: Effect of ionic strength and protein characteristics

(2009) Melani C. Stone et al.   JOURNAL OF CHROMATOGRAPHY A

Modeling electrostatic exclusion effects during ion exchange chromatography of monoclonal antibodies

(2008) Andrew L. Zydney et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Predictive Approach to Correlating Protein Adsorption Isotherms on Ion-Exchange Media

(2008) Xuankuo Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Multiscale Modeling of Protein Uptake Patterns in Chromatographic Particles

(2008) A. M. Lenhoff   LANGMUIR