Protein adsorption on ion exchange adsorbers: A comparison of a stoichiometric and non-stoichiometric modeling approach

Straightforward method for calibration of mechanistic cation exchange chromatography models for industrial applications

(2020) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling

(2019) Steven W. Benner et al.   JOURNAL OF CHROMATOGRAPHY A

Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation

(2019) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads

(2018) Arch Creasy et al.   Biotechnology Journal

Prediction tool for loading, isocratic elution, gradient elution and scaling up of ion exchange chromatography of proteins

(2018) Wojciech Kazimierz Marek et al.   JOURNAL OF CHROMATOGRAPHY A

Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads

(2018) Arch Creasy et al.   Biotechnology Journal

Prediction uncertainty assessment of chromatography models using Bayesian inference

(2018) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

Relating saturation capacity to charge density in strong cation exchangers

(2017) Fabian Steinebach et al.   JOURNAL OF CHROMATOGRAPHY A

Multi-state steric mass action model and case study on complex high loading behavior of mAb on ion exchange tentacle resin

(2017) Juliane Diedrich et al.   JOURNAL OF CHROMATOGRAPHY A

Modeling of complex antibody elution behavior under high protein load densities in ion exchange chromatography using an asymmetric activity coefficient

(2017) Thiemo C. Huuk et al.   Biotechnology Journal

Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients

(2017) Arch Creasy et al.   Biotechnology Journal

Ionic strength-dependent changes in tentacular ion exchangers with variable ligand density. I. Structural properties

(2016) Rahul Bhambure et al.   JOURNAL OF CHROMATOGRAPHY A

Protein adsorption on ion exchange resins and monoclonal antibody charge variant modulation

(2016) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Charge Regulation in the Electrical Double Layer: Ion Adsorption and Surface Interactions

(2015) Gregor Trefalt et al.   LANGMUIR

Explaining the Non-Newtonian Character of Aggregating Monoclonal Antibody Solutions Using Small-Angle Neutron Scattering

(2014) Maria Monica Castellanos et al.   BIOPHYSICAL JOURNAL

A model based approach for identifying robust operating conditions for industrial chromatography with process variability

(2014) Edward J. Close et al.   CHEMICAL ENGINEERING SCIENCE

Adjoint-based estimation and optimization for column liquid chromatography models

(2014) Tobias Hahn et al.   COMPUTERS & CHEMICAL ENGINEERING

Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates

(2014) Niklas Borg et al.   JOURNAL OF CHROMATOGRAPHY A

Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection

(2014) Alexandra Lavoisier et al.   mAbs

Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography

(2014) Thiemo C. Huuk et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Model-based prediction of monoclonal antibody retention in ion-exchange chromatography

(2013) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints

(2013) Nicholas J. Clark et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Model-integrated process development demonstrated on the optimization of a robotic cation exchange step

(2012) A. Osberghaus et al.   CHEMICAL ENGINEERING SCIENCE

Optimizing a chromatographic three component separation: A comparison of mechanistic and empiric modeling approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

(2012) Candy K.S. Ng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Madelung energy of Yukawa lattices

(2012) P. C. N. Pereira et al.   PHYSICAL REVIEW E

Model-Based Process Challenge of an Industrial Ion-Exchange Chromatography Step

(2011) K. Westerberg et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

(2010) Spyridon Gerontas et al.   JOURNAL OF CHROMATOGRAPHY A

Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

(2010) Bertrand Guélat et al.   JOURNAL OF CHROMATOGRAPHY A

Streaming potential studies of colloid, polyelectrolyte and protein deposition

(2009) Z. Adamczyk et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Binary adsorption of globular proteins on ion-exchange media

(2009) Xuankuo Xu et al.   JOURNAL OF CHROMATOGRAPHY A

A Predictive Approach to Correlating Protein Adsorption Isotherms on Ion-Exchange Media

(2008) Xuankuo Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B