Wounds under diabetic milieu: The role of immune cellar components and signaling pathways

Tetrahedral Framework Nucleic Acids Can Alleviate Taurocholate-Induced Severe Acute Pancreatitis and Its Subsequent Multiorgan Injury in Mice

(2022) Yun Wang et al.   NANO LETTERS

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

(2022) Sophia Maschalidi et al.   NATURE

Impaired wound healing in diabetes

(2022) Laura Swoboda et al.   Journal of Wound Care

Latent autoimmune diabetes in adults in China

(2022) Junlin Qiu et al.   Frontiers in Immunology

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

(2022) Chiel van Geffen et al.   Frontiers in Immunology

Dendritic Cells Revisited

(2021) Mar Cabeza-Cabrerizo et al.   Annual Review of Immunology

Tea consumption and long-term risk of type 2 diabetes and diabetic complications: a cohort study of 0.5 million Chinese adults

(2021) Jia Nie et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

(2021) Yi Li et al.   Stem Cell Research & Therapy

Tetrahedral Framework Nucleic Acids Induce Immune Tolerance and Prevent the Onset of Type 1 Diabetes

(2021) Shaojingya Gao et al.   NANO LETTERS

Feeding the Accretion Disk from the Dusty Torus in a Reddened Quasar

(2021) Ge Li et al.   ASTROPHYSICAL JOURNAL

Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds

(2021) Savannah M. Aitcheson et al.   MOLECULES

Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments

(2021) Rou Wan et al.   WOUND REPAIR AND REGENERATION

Beyond IgE: Alternative Mast Cell Activation Across Different Disease States

(2020) David O. Lyons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternatively activated macrophages; a double-edged sword in allergic asthma

(2020) Mohamed Hamed Abdelaziz et al.   Journal of Translational Medicine

Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors

(2020) Ashish Thakur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrophages of diverse phenotypes drive vascularization of engineered tissues

(2020) P. L. Graney et al.   Science Advances

Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers.

(2020) Georgios Theocharidis et al.   DIABETES

Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing

(2020) Frank M. Davis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mast Cells in Diabetes and Diabetic Wound Healing

(2020) Jie Dong et al.   ADVANCES IN THERAPY

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

(2020) Jonas Ecker et al.   NEURO-ONCOLOGY

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

(2020) Venkat Giri Magupalli et al.   SCIENCE

Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products

(2020) Olga L. Gurvich et al.   Scientific Reports

Mechanistic Actions of microRNAs in Diabetic Wound Healing

(2020) Marija Petkovic et al.   Cells

Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair

(2020) Frank M. Davis et al.   JCI Insight

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

(2020) Yanyun Jiang et al.   JCI Insight

MFG-E8 accelerates wound healing in diabetes by regulating “NLRP3 inflammasome-neutrophil extracellular traps” axis

(2020) Wei Huang et al.   Cell Death Discovery

Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance

(2020) Nuray Erin et al.   DRUG RESISTANCE UPDATES

Targeting post-translational histone modifying enzymes in glioblastoma

(2020) Elena Kunadis et al.   PHARMACOLOGY & THERAPEUTICS

NLRP3 Activation Induced by Neutrophil Extracellular Traps Sustains Inflammatory Response in the Diabetic Wound

(2019) Dan Liu et al.   CLINICAL SCIENCE

Immune aging in diabetes and its implications in wound healing

(2019) J. Moura et al.   CLINICAL IMMUNOLOGY

Type 2 diabetes is associated with the accumulation of senescent T cells

(2019) E. Y. M. Lau et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Innate immune cell–epithelial crosstalk during wound repair

(2019) Jennifer C. Brazil et al.   JOURNAL OF CLINICAL INVESTIGATION

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

(2019) João Moura et al.   Scientific Reports

Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro

(2019) Lars Hummitzsch et al.   Stem Cells International

MicroRNAs as Molecular Switches in Macrophage Activation

(2019) Graziella Curtale et al.   Frontiers in Immunology

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation

(2019) Kang I. Ko et al.   DIABETES

Sodium butyrate attenuates angiotensin II‐induced cardiac hypertrophy by inhibiting COX2/PGE2 pathway via a HDAC5/HDAC6‐dependent mechanism

(2019) Linlin Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Topical Application Of A Mast Cell Stabilizer Improves Impaired Diabetic Wound Healing

(2019) Ana Tellechea et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction

(2019) Salma Alrdahe et al.   PLoS One

Accelerated wound healing in diabetic mice by miRNA-497 and its anti-inflammatory activity

(2019) Eunmi Ban et al.   BIOMEDICINE & PHARMACOTHERAPY

The MSC-Derived Exosomal lncRNA H19 Promotes Wound Healing in Diabetic Foot Ulcers by Upregulating PTEN via MicroRNA-152-3p

(2019) Bo Li et al.   Molecular Therapy-Nucleic Acids

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

(2019) Sujuan Ding et al.   Biomolecules

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Younger people with Type 2 diabetes have poorer self-care practices compared with older people: results from the Australian National Diabetes Audit

(2018) N. Nanayakkara et al.   DIABETIC MEDICINE

MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target

(2018) Tao Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

(2018) Paulina Krzyszczyk et al.   Frontiers in Physiology

Type 2 diabetes in adolescents and young adults

(2018) Nadia Lascar et al.   Lancet Diabetes & Endocrinology

Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes

(2018) Juan Huang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Human adipose tissue-derived stromal cells act as functional pericytes in mice and suppress high-glucose-induced proinflammatory activation of bovine retinal endothelial cells

(2018) Ghazaleh Hajmousa et al.   DIABETOLOGIA

Arctigenin Ameliorates Inflammation by Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock

(2018) Hui Shi et al.   INFLAMMATION

Insulin promotes macrophage phenotype transition through PI3K/Akt and PPAR-γ signaling during diabetic wound healing

(2018) Tianyi Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

(2018) Zhiqing Li et al.   IMMUNITY

M2b macrophage polarization and its roles in diseases

(2018) Le-xun Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Diabetes and Wound Angiogenesis

(2017) Uzoagu Okonkwo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

(2017) Mark Hesketh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-132 with Therapeutic Potential in Chronic Wounds

(2017) Xi Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-4/IL-13–mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury

(2017) Ming-Zhi Zhang et al.   KIDNEY INTERNATIONAL

Blocking AGE-RAGE Signaling Improved Functional Disorders of Macrophages in Diabetic Wound

(2017) Qi Wang et al.   Journal of Diabetes Research

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages

(2017) Xiaotian Zhang et al.   Journal of Diabetes Research

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing

(2017) Andrew S. Kimball et al.   Frontiers in Immunology

IL-15 Enhances Activation and IGF-1 Production of Dendritic Epidermal T Cells to Promote Wound Healing in Diabetic Mice

(2017) Yangping Wang et al.   Frontiers in Immunology

All-cause mortality among diabetic foot patients and related risk factors in Saudi Arabia

(2017) Khalid Al-Rubeaan et al.   PLoS One

Weakened IL-15 Production and Impaired mTOR Activation Alter Dendritic Epidermal T Cell Homeostasis in Diabetic Mice

(2017) Zhongyang Liu et al.   Scientific Reports

Impaired T-cell differentiation in diabetic foot ulceration

(2016) João Moura et al.   Cellular & Molecular Immunology

Topical Prostaglandin E Analog Restores Defective Dendritic Cell–Mediated Th17 Host Defense Against Methicillin-ResistantStaphylococcus Aureusin the Skin of Diabetic Mice

(2016) Naiara N. Dejani et al.   DIABETES

Interferon beta overexpression attenuates adipose tissue inflammation and high-fat diet-induced obesity and maintains glucose homeostasis

(2016) M Alsaggar et al.   GENE THERAPY

Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes

(2016) Amitava Das et al.   JOURNAL OF IMMUNOLOGY

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

(2016) Kobina Essandoh et al.   SHOCK

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

(2016) Jaba Gamrekelashvili et al.   Nature Communications

The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification

(2016) Amber M. Kay et al.   Journal of Diabetes Research

AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes

(2016) Yuanyuan Guo et al.   Scientific Reports

Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation

(2015) Racquel Domingo-Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Histone deacetylases: structural determinants of inhibitor selectivity

(2015) Carmina Micelli et al.   DRUG DISCOVERY TODAY

Epigenetic modifications of the immune system in health and disease

(2015) Yuuki Obata et al.   IMMUNOLOGY AND CELL BIOLOGY

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing

(2015) Dongqing Li et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2015) Sushant Bhattacharya et al.   MOLECULAR MEDICINE

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

(2015) Luciano Ribeiro Filgueiras et al.   Science Signaling

The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing

(2015) Joon-Il Jun et al.   Nature Communications

Leukotriene B4–mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes

(2015) Luciano Ribeiro Filgueiras et al.   Science Signaling

Dysregulation of circulating CD4+CXCR5+ T cells in type 2 diabetes mellitus

(2014) Qijin Wang et al.   APMIS

Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

(2014) Julio Tobon-Velasco et al.   CNS & Neurological Disorders-Drug Targets

Circulating CD3+56+ Cell Subset in Pre-diabetes

(2014) M. Dworacka et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease

(2014) Jun Feng et al.   Lipids in Health and Disease

The Monocyte to Macrophage Transition in the Murine Sterile Wound

(2014) Meredith J. Crane et al.   PLoS One

Wound Administration of M2-Polarized Macrophages Does Not Improve Murine Cutaneous Healing Responses

(2014) Nadine Jetten et al.   PLoS One

Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production

(2014) Bin Wang et al.   Nature Communications

Micro-inflammation Characterized by Disturbed Treg/Teff Balance with Increasing sIL-2R in Patients with Type 2 Diabetes

(2013) B. Cai et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Topical treatment with the opioid antagonist naltrexone accelerates the remodeling phase of full-thickness wound healing in type 1 diabetic rats

(2013) Jessica A Immonen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Myeloid-Derived Suppressor Cells Protect Mouse Models from Autoimmune Arthritis via Controlling Inflammatory Response

(2013) Lei Zhang et al.   INFLAMMATION

Prostaglandin E2-Induced Changes in Alveolar Macrophage Scavenger Receptor Profiles Differentially Alter Phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus Post-Bone Marrow Transplant

(2013) R. Domingo-Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Macrophage phenotypes during tissue repair

(2013) Margaret L. Novak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lipid-based carriers of microRNAs and intercellular communication

(2012) Kasey C. Vickers et al.   CURRENT OPINION IN LIPIDOLOGY

Wound Repair and Regeneration

(2012) J.M. Reinke et al.   EUROPEAN SURGICAL RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse CD11b + Gr-1 + Myeloid Cells Can Promote Th17 Cell Differentiation and Experimental Autoimmune Encephalomyelitis

(2012) Huanfa Yi et al.   JOURNAL OF IMMUNOLOGY

Reduced Il17a Expression Distinguishes a Ly6c lo MHCII hi Macrophage Population Promoting Wound Healing

(2012) Mathieu P. Rodero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

(2012) Juan Li et al.   PLoS One

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Functions of skin-resident γδ T cells

(2011) Amanda S. MacLeod et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states

(2011) David L Morris et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice

(2011) Rita Mirza et al.   CYTOKINE

Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity

(2011) Kristen R. Taylor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes

(2011) Fahd Al-Mulla et al.   Molecular BioSystems

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Role of wound macrophages in skin flap loss or survival in an experimental diabetes model

(2010) C. Schürmann et al.   BRITISH JOURNAL OF SURGERY

Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages

(2010) Qingshan Wang et al.   CELL RESEARCH

Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages

(2010) H. Hamilton Outtz et al.   JOURNAL OF IMMUNOLOGY

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

γδ T Cells Are Reduced and Rendered Unresponsive by Hyperglycemia and Chronic TNFα in Mouse Models of Obesity and Metabolic Disease

(2010) Kristen R. Taylor et al.   PLoS One

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

IIp45 Inhibits Cell Migration through Inhibition of HDAC6

(2009) Ying Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses

(2009) G. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HOXA3 Modulates Injury-Induced Mobilization and Recruitment of Bone Marrow-Derived Cells

(2009) Kimberly A. Mace et al.   STEM CELLS

Hyperoxia, Endothelial Progenitor Cell Mobilization, and Diabetic Wound Healing

(2008) Zhao-Jun Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum–transfer arthritis

(2008) Mei Chen et al.   ARTHRITIS AND RHEUMATISM

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

(2008) R. B. Parmigiani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA