Article
Pharmacology & Pharmacy
Jiamin Zhang, Xiaoyan Zhou, Hua Hao
Summary: TAMs play a crucial role in tumorigenesis and malignant progression, and understanding their phenotype-switching is important for tumor therapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Catharine A. Mielnik, Mary A. Binko, Yuxiao Chen, Adam J. Funk, Emily M. Johansson, Katheron Intson, Nirun Sivananthan, Rehnuma Islam, Marija Milenkovic, Wendy Horsfall, Ruth A. Ross, Laurent Groc, Ali Salahpour, Robert E. McCullumsmith, Shreejoy Tripathy, Evelyn K. Lambe, Amy J. Ramsey
Summary: NMDARs play a crucial role in brain development and connectivity, with dysfunction leading to various neurodevelopmental disorders. Restoring NMDAR function through gene editing in adulthood significantly improves cognitive functions, providing a new approach for the treatment of neurodevelopmental disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Federica Cirillo, Laura Mangiavini, Paolo La Rocca, Marco Piccoli, Andrea Ghiroldi, Paola Rota, Adriana Tarantino, Barbara Canciani, Simona Coviello, Carmelo Messina, Giuseppe Ciconte, Carlo Pappone, Giuseppe Maria Peretti, Luigi Anastasia
Summary: Sarcopenia, an age-related decline in muscle mass and strength, is associated with metabolic disease and increased risk of cardiovascular morbidity and mortality. This study found that the hypoxia inducible factor HIF-1α plays a role in sarcopenia and is involved in satellite cell homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Sinem Gunalp, Derya Goksu Helvaci, Aysenur Oner, Ahmet Bursali, Alessandra Conforte, Hueseyin Guener, Gokhan Karakulah, Eva Szegezdi, Duygu Sag
Summary: This study investigates the role of TNF-related apoptosis-inducing ligand (TRAIL) in macrophage polarization. It shows that TRAIL promotes the polarization of human macrophages towards a proinflammatory M1 phenotype via both DR4 and DR5, suggesting that targeting DRs can enhance the anti-tumorigenic response of macrophages in the tumor microenvironment by increasing M1 polarization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Cassandra R. Harapas, Kim S. Robinson, Kenneth Lay, Jasmine Wong, Ricardo Moreno Traspas, Nasrin Nabavizadeh, Annick Rass-Rothschild, Bertrand Boisson, Scott B. Drutman, Pawat Laohamonthonkul, Devon Bonner, Jingwei Rachel Xiong, Mark D. Gorrell, Sophia Davidson, Chien-Hsiung Yu, Mark D. Fleming, Jonas Gudera, Jerry Stein, Miriam Ben-Harosh, Emily Groopman, Akiko Shimamura, Hannah Tamary, Hulya Kayserili, Nevin Hatipoglu, Jean-Laurent Casanova, Jonathan A. Bernstein, Franklin L. Zhong, Seth L. Masters, Bruno Reversade
Summary: In this study, we report that DPP9 deficiency is associated with immune-related defects and other symptoms, and provide evidence that these defects are mainly caused by abnormal activation of the NLRP1 inflammasome and IL-1 ss signaling. This study highlights DPP9 deficiency as a Mendelian genetic disorder.
SCIENCE IMMUNOLOGY
(2022)
Article
Neurosciences
Sridevi Venkatesan, Mary A. Binko, Catharine A. Mielnik, Amy J. Ramsey, Evelyn K. Lambe
Summary: Glutamatergic NMDA receptors play a critical role in cognitive function, and their reduced expression leads to intellectual disability. Through experiments on mice, it was found that synaptic and extrasynaptic NMDARs have different vulnerability to genetic disruption, with extrasynaptic NMDARs being more affected. Intervention targeting extrasynaptic NMDARs can rescue cognitive integration and improve cognitive function.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Goutham Ganesh, Kunka Mohanram Ramkumar
Summary: In this study, aberrations in Nrf2 signaling in macrophages under a hyperglycemic microenvironment were characterized, and the Nrf2 activator pterostilbene was found to improve these abnormalities and restore some related indicators.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Immunology
Yulia Alexandrova, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Summary: Despite successful antiretroviral therapy, people living with HIV still experience a higher rate of respiratory infections, lung cancers, and chronic lung disease. The lung mucosa, previously overlooked as an HIV reservoir site, plays a significant role in this phenomenon. Residual levels of HIV in deep tissues, combined with chronic immune activation and pulmonary inflammation, contribute to viral persistence. Factors such as smoking, gut and lung dysbiosis, and co-infections further exacerbate residual viral replication and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrey Elchaninov, Polina Vishnyakova, Egor Menyailo, Gennady Sukhikh, Timur Fatkhudinov
Summary: Macrophages play a key role in maintaining tissue homeostasis, particularly in the liver, and their interactions with other cell lineages are crucial for maintaining their phenotypic and functional characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Anushka Chakravorty, Ankit Sharma, Vasu Sheeba, Ravi Manjithaya
Summary: This study investigates synaptic dysfunction using a Drosophila model of Machado-Joseph Disease (MJD). The researchers found that the polyQ repeat mutant protein ataxin-3 impairs motor neuron function and behavior. They also discovered that overexpression of the autophagy-related protein Atg8a rescues these defects. This study provides insights into potential therapeutic targets for synaptopathies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Fangfei Wang, Quan He, Zhiqian Gao, Andrew N. Redington
Summary: The study indicates that cardiac-specific Atg5 knockdown results in the development of age-related cardiomyopathy, and remote ischemic conditioning can reverse the molecular and structural phenotype both acutely and chronically.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Review
Medicine, Research & Experimental
Xichen Wang, Benson O. A. Botchway, Yong Zhang, Min Huang, Xuehong Liu
Summary: Nerve injury has detrimental effects on human motor and sensory function, disrupting nerve structure integrity. Activation of glial cells and disruption of synaptic integrity lead to inflammation and pain hypersensitivity. Maresin1, an omega-3 fatty acid derivative, has shown beneficial effects in various animal models of nerve injury. This review summarizes the anti-inflammatory, neuroprotective, and pain hypersensitivity effects of maresin1 and provides the theoretical basis for its clinical application in treating nerve injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Kevin Shenderov, Samuel L. Collins, Jonathan D. Powell, Maureen R. Horton
Summary: IPF is a debilitating disease with limited treatment options, with lung transplantation being the only cure. Recent research has highlighted immune dysregulation as a key factor in the pathophysiology of the disease, suggesting that a better understanding of the immune system's role in IPF may lead to the development of targeted therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Engineering, Biomedical
Pengfei Tian, Limin Zhao, Jua Kim, Xian Li, Chunyu Liu, Xu Cui, Tao Liang, Yunbo Du, Xiehui Chen, Haobo Pan
Summary: In this study, glucose and hydrogen peroxide dual-responsive borosilicate glass (BSG) scaffolds loaded with epigallocatechin gallate (EGCG) were developed to modulate the abnormal inflammation of diabetic alveolar bone defects. The release of EGCG by BSG could directly regulate the shift of macrophages from M1 to the M2 phenotype by promoting autophagy and lessening the inhibition of autophagic flux. Moreover, EGCG can also indirectly regulate the polarization phenotype of macrophages by reducing the activation of NF-kappa b in stem cells and restoring its immunoregulatory capacity.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Madeline Cramer, Jordan Chang, Hongshuai Li, Aurelie Serrero, Mohammed El-Kurdi, Martijn Cox, Frederick J. Schoen, Stephen F. Badylak
Summary: The study demonstrates that different biomaterials elicit distinct types of macrophage infiltration and host remodeling responses, suggesting that the rat subcutaneous implantation model can be used to predict in vivo biocompatibility and regenerative potential for cardiovascular biomaterials.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Asmaa Elkhamesy, Manar Refaat, Mona S. O. Gouida, Salma S. Alrdahe, Magdy M. Youssef
Summary: The study showed that curcumin and selenium have a protective effect against hepatocellular carcinoma induced by CCl4, restoring abnormal changes in biochemical parameters and inhibiting hepatic cell apoptosis through potent antioxidant activity.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Maha S. Elsayed, Noha M. Eldadamony, Salma S. T. Alrdahe, WesamEldin I. A. Saber
Summary: This study explored the one-step bioprocessing of date palm fronds into citric acid using Trichoderma harzianum PWN6, selected for its high organic acid productivity. The innovative use of both DSD and ANN modeling techniques showed that the ANN model outperformed the DSD model in predicting citric acid production. The study confirmed citric acid as the only identified organic acid product, with Trichoderma harzianum PWN6 and date palm fronds showing promise for citric acid biosynthesis.
Article
Plant Sciences
Hamed M. El-Shora, Gehan F. Massoud, Ghada A. El-Sherbeny, Salma Saleh Alrdahe, Doaa B. Darwish
Summary: Lead stress negatively impacts the physiological parameters of Salvia plants, but ALA application can effectively improve germination and protein content while reducing oxidative damage. This suggests that ALA at a certain concentration level can protect plants from heavy metal stress, recommending its application for alleviating lead stress.
Article
Biochemistry & Molecular Biology
Aishah E. Albalawi, Norah A. Althobaiti, Salma Saleh Alrdahe, Reem Hasaballah Alhasani, Fatima S. Alaryani, Mona Nasser BinMowyna
Summary: The study demonstrated that treatment with 10-HDA at doses of 2.5 and 5 mg/kg, especially in combination with CP, significantly reduced tumor growth, tumor markers, serum liver and kidney levels, lipid peroxidation and nitric oxide, TNF-alpha levels, and Bcl-2 expression. Additionally, 10-HDA in combination with CP also significantly improved antioxidant enzyme levels and expression of caspase-3 and Bax genes.
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Basma G. Eid, Usama A. Fahmy, Osama A. A. Ahmed, Ashraf B. Abdel-Naim, Abdulmohsin J. Alamoudi, Shareefa A. Alghamdi, Hadeel Al Sadoun, Basmah M. Eldakhakhny, Filippo Caraci, Wesam H. Abdulaal
Summary: The study investigates the potential of a nanoconjugate of CTX and MEL loaded in hydroxypropyl methylcellulose gel to improve wound healing in diabetic rats. The results show that the nanocomplex enhances epithelium regeneration, reduces oxidative stress, decreases pro-inflammatory cytokines, and increases collagen expression, highlighting its promising application in wound healing research.
Article
Microbiology
Momen Askoura, Hisham A. Abbas, Hadeel Al Sadoun, Wesam H. Abdulaal, Amr S. Abu Lila, Khaled Almansour, Farhan Alshammari, El-Sayed Khafagy, Tarek S. Ibrahim, Wael A. H. Hegazy
Summary: This study investigated the role of IL-33, IL-17, and IL-25 in patients with hepatitis C virus (HCV) and the progression of the disease from chronicity to hepatocellular carcinoma. The results showed that the serum levels of IL-33 and IL-17 significantly increased in patients with chronic hepatitis C and hepatocellular carcinoma. IL-33 was also found to be associated with liver fibrosis progression and viral load, while IL-17 and IL-25 were mainly related to the development of hepatocellular carcinoma.
Article
Biochemistry & Molecular Biology
Adil Farooq, Arfa Iqbal, Nosheen Fatima Rana, Misha Fatima, Tuba Maryam, Farhat Batool, Zahra Rehman, Farid Menaa, Shabia Azhar, Afrah Nawaz, Faheem Amin, Zuhair M. Mohammedsaleh, Salma Saleh Alrdahe
Summary: Chronic liver disease (CLD) is a global threat to human population, mainly caused by alcohol-related liver disease (ALD) and non-alcohol fatty liver disease (NAFLD). NAFLD may progress to non-alcoholic steatohepatitis (NASH), leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. Vitexin, a natural flavonoid, has been reported to inhibit NAFLD. However, its low bioavailability and efficacy due to hydrophobic nature limit its therapeutic potential. In this study, vitexin encapsulated liposomes with polyethylene glycol (PEG) coating were developed and showed promising results for the treatment of liver cirrhosis through oral drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Yu-Juan Zhang, Muhammad Tahir Khan, Madeeha Shahzad Lodhi, Hadba Al-Amrah, Salma Saleh Alrdahe, Hanan Ali Alatawi, Doaa Bahaa Eldin Darwish
Summary: This study investigated mutations and their effects on pncB1 and pncB2 structures in drug-resistant Mycobacterium tuberculosis isolates from Pakistan, revealing novel mutations and observing impacts on protein stability.
Article
Biotechnology & Applied Microbiology
Aishah E. Albalawi, Norah A. Althobaiti, Salma S. Alrdahe, Reem Hasaballah Alhasani, Fatima S. Alaryani, Mona N. BinMowyna
Summary: The present study evaluated the antitumor effects of royal jelly (RJ) obtained from Apis mellifera compared with cyclophosphamide against Ehrlich solid tumors (EST) in mice. The results showed that RJ significantly reduced tumor volume, inhibited tumor growth, and improved antioxidant and anti-inflammatory effects in EST mice. These findings suggest that oral administration of RJ may be a promising anticancer agent.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Microbiology
Ashraf Elsayed, Zeiad Moussa, Salma Saleh Alrdahe, Maha Mohammed Alharbi, Abeer A. Ghoniem, Ayman Y. El-khateeb, WesamEldin I. A. Saber
Summary: In this study, the biosorption of Co(II) by Pseudomonas alcaliphila NEWG-2 was modeled using definitive screening design (DSD) and artificial neural network (ANN). Factors such as peptone, incubation time, pH, glycerol, glucose, K2HPO4, and initial cobalt were found to have a significant effect on the biosorption process. The ANN model showed accurate prediction ability with high response for training and validation, leading to a 96.32 +/- 2.1% cobalt bioremoval when applying the optimal levels obtained by the ANN model. No attempt has been made to optimize the biosorption of Co(II) by P. alcaliphila using DSD or ANN paradigm, making this study significant in filling this gap.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Namrita Kaur, Andrea Ruiz-Velasco, Rida Raja, Gareth Howell, Jessica M. Miller, Riham R. E. Abouleisa, Qinghui Ou, Kimberly Mace, Susanne S. Hille, Norbert Frey, Pablo Binder, Craig P. Smith, Helene Fachim, Handrean Soran, Eileithyia Swanton, Tamer M. A. Mohamed, Oliver J. Mueller, Xin Wang, Jonathan Chernoff, Elizabeth J. Cartwright, Wei Liu
Summary: Myocardial inflammation contributes to cardiomyopathy in diabetic patients, primarily through inflammation induced by abnormal ER. Studies have revealed that ER stress-induced CHOP is a novel regulator of HMGB1 in the heart, with HMGB1 release promoting macrophage polarization and aggravating myocardial inflammation.
Review
Cell Biology
Hadeel Al Sadoun
Summary: Macrophage differentiation and polarization are crucial for successful wound healing. Macrophages exhibit plasticity, allowing them to adopt different functional states, contributing to inflammation resolution and tissue regeneration. Reparative macrophages are a source of growth factors, playing a critical role in wound repair. Dysregulation of macrophages is associated with nonhealing wounds and fibrosis. Therapeutic manipulation of macrophages, such as promoting secretion of growth factors, shows promise in promoting wound healing. The example of Hoxa3 overexpression highlights the potential of repolarizing macrophages as a therapeutic strategy.
Article
Cell Biology
Mohammed Ali, Long Miao, Fathia A. Soudy, Doaa Bahaa Eldin Darwish, Salma Saleh Alrdahe, Dikhnah Alshehri, Vagner A. Benedito, Million Tadege, Xiaobo Wang, Jian Zhao
Summary: Over-expressing five terpene synthesis genes isolated from Glycine max and Salvia guaranitica enhanced root nodule formation in soybean by increasing root nodule numbers, fresh weight, and root length. The terpene content in transgenic soybean hairy roots, including monoterpenes, sesquiterpenes, and diterpenes, was significantly increased compared to the control, suggesting potential effects on soybean root growth and nodulation. This study provides novel insights into the epistatic relationship between terpenoids, root development, and nodulation in soybean.
Article
Biochemistry & Molecular Biology
Abdullah Hamadi, Rashid Mir, Ali Mahzari, Abdulrahim Hakami, Reema Almotairi, Gasim Dobie, Fawaz Hamdi, Mohammed Hassan Nahari, Razan Alhefzi, Mohammed Alasseiri, Nora Y. Hakami, Hadeel Al Sadoun, Osama M. Al-Amer, Jameel Barnawi, Hassan A. Madkhali
Summary: Recent studies have shown that microRNA and VEGF are genetic modifiers associated with fetal hemoglobin levels and can reduce the impact of sickle hemoglobin (HbS) in patients. This study found significant associations between miR-423 C>T genotype and severity of SCD, as well as between VEGF-2578 C>A genotype and SCD severity. Further research is needed to confirm these findings.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ragaa A. Hamouda, Neveen G. El-Boraey, Badr E. El Bialy, Salma Saleh Alrdahe, Doaa Bahaa Eldin Darwish
Summary: The addition of vitamins during Spirulina platensis cultivation can improve its biomass, pigment, and phytochemical content, thereby increasing its antioxidant capacity.
GREEN PROCESSING AND SYNTHESIS
(2022)