LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis

The m6A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia

(2022) Lina Sang et al.   Journal of Cancer

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

(2021) Jinyan Wang et al.   Cancer Cell International

LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification

(2021) Pingfu Hou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination

(2021) Huajie Cai et al.   ARCHIVES OF PHARMACAL RESEARCH

Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR

(2021) Sujian Shen et al.   PHYSIOLOGICAL RESEARCH

Long Noncoding RNA lnc-TSSK2-8 Activates Canonical Wnt/β-Catenin Signaling Through Small Heat Shock Proteins HSPA6 and CRYAB

(2021) Jingjing Fa et al.   Frontiers in Cell and Developmental Biology

Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p

(2021) Chunping Zhu et al.   ACTA DIABETOLOGICA

Changes in N6-Methyladenosine Modification Modulate Diabetic Cardiomyopathy by Reducing Myocardial Fibrosis and Myocyte Hypertrophy

(2021) Wenhao Ju et al.   Frontiers in Cell and Developmental Biology

LncRNA MALAT1 regulates diabetic cardiac fibroblasts through the Hippo/YAP signaling pathway

(2020) Jiangwen Liu et al.   Biochemistry and Cell Biology

Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR‐141‐mediated NLRP3 inflammasome and TGF‐β1/Smads signaling in diabetic cardiomyopathy

(2020) Hui Che et al.   FASEB JOURNAL

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways

(2020) Lei Gao et al.   Cell Death & Disease

Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors

(2020) Jiaying Lin et al.   Stem Cells International

Long non‐coding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2

(2020) Fengying Jing et al.   CELL BIOLOGY INTERNATIONAL

N6-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation

(2020) Tianhe Zhao et al.   ENVIRONMENTAL POLLUTION

LncRNA-MIAT-Mediated miR-214-3p Silencing Is Responsible for IL-17 Production and Cardiac Fibrosis in Diabetic Cardiomyopathy

(2020) Yanqing Qi et al.   Frontiers in Cell and Developmental Biology

N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis

(2020) Ana Quiles-Jiménez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA

(2020) Xiang-Qian Gao et al.   NATURE CELL BIOLOGY

The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

(2019) Lisa E. Dorn et al.   CIRCULATION

Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy

(2019) Dezhi Zheng et al.   FEBS Journal

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Examination of the associations between m6A-associated single-nucleotide polymorphisms and blood pressure

(2019) Xing-Bo Mo et al.   HYPERTENSION RESEARCH

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

Diabetic Cardiomyopathy

(2019) Stefania Paolillo et al.   Heart Failure Clinics

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

(2019) Yun Wang et al.   Molecular Cancer

FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair

(2018) Prabhu Mathiyalagan et al.   CIRCULATION

Long Noncoding RNA Discovery in Cardiovascular Disease

(2018) Tamer Sallam et al.   CIRCULATION RESEARCH

AirnRegulates Igf2bp2 Translation in CardiomyocytesNovelty and Significance

(2018) Mohammed Rabiul Hosen et al.   CIRCULATION RESEARCH

Poor Glycemic Control Is Associated With Increased Extracellular Volume Fraction in Diabetes

(2018) Ahmed Al-Badri et al.   DIABETES CARE

Ablation of interleukin-17 alleviated cardiac interstitial fibrosis and improved cardiac function via inhibiting long non-coding RNA-AK081284 in diabetic mice

(2018) Yang Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Multipoint targeting of TGF-β/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis

(2018) Hyang-Hee Seo et al.   CELL DEATH AND DIFFERENTIATION

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

Of mice and men: models and mechanisms of diabetic cardiomyopathy

(2018) Christian Riehle et al.   BASIC RESEARCH IN CARDIOLOGY

Increased left ventricular extracellular volume and enhanced twist function in type 1 diabetic individuals

(2017) Zainisha Vasanji et al.   JOURNAL OF APPLIED PHYSIOLOGY

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

(2017) Rudi Micheletti et al.   Science Translational Medicine

LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway

(2017) Hui Tao et al.   TOXICOLOGY

Transcriptomic profile of leg muscle during early growth in chicken

(2017) Qian Xue et al.   PLoS One

MIAT Is a Pro-fibrotic Long Non-coding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium

(2017) Xuefeng Qu et al.   Scientific Reports

Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy

(2016) Christian Bär et al.   CIRCULATION

Association of Cardiovascular Risk Factors and Myocardial Fibrosis With Early Cardiac Dysfunction in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

(2016) Anderson C. Armstrong et al.   DIABETES CARE

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins

(2015) Ning Dai et al.   Cell Metabolism

MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

(2015) Varun Nagpal et al.   CIRCULATION

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis

(2015) Esther E. Creemers et al.   CIRCULATION RESEARCH

Discovery and functional characterization of cardiovascular long noncoding RNAs

(2015) Samir Ounzain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy

(2015) Richard E Gilbert et al.   LANCET

Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation

(2015) Chelsea Marcho et al.   Epigenetics & Chromatin

The Long Noncoding RNA CHRF Regulates Cardiac Hypertrophy by Targeting miR-489

(2014) Kun Wang et al.   CIRCULATION RESEARCH

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

(2014) Michele Cavalera et al.   Translational Research

Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window

(2013) F. Santoro et al.   DEVELOPMENT

Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission

(2013) T. C. Wong et al.   EUROPEAN HEART JOURNAL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation

(2011) Hideo Nakamura et al.   Circulation-Heart Failure

Epigenetic modifications and human pathologies: cancer and CVD

(2010) Susan J. Duthie   PROCEEDINGS OF THE NUTRITION SOCIETY