Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis (FHL) patients in India

(2015) Snehal Mhatre et al.   BLOOD CELLS MOLECULES AND DISEASES

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

(2015) Imran G House et al.   IMMUNOLOGY AND CELL BIOLOGY

Perforin: structure, function, and role in human immunopathology

(2015) Ilia Voskoboinik et al.   IMMUNOLOGICAL REVIEWS

Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance

(2014) Xavier S. Revelo et al.   DIABETES

A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

(2014) Amelia J. Brennan et al.   JOURNAL OF IMMUNOLOGY

Activation of neurotensin receptor type 1 attenuates locomotor activity

(2014) Chelsea A. Vadnie et al.   NEUROPHARMACOLOGY

Perforin Competent CD8 T Cells Are Sufficient to Cause Immune-Mediated Blood-Brain Barrier Disruption

(2014) Holly L. Johnson et al.   PLoS One

Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells

(2013) C. E. Terrell et al.   BLOOD

Mixed hematopoietic or T-cell chimerism above a minimal threshold restores perforin-dependent immune regulation in perforin-deficient mice

(2013) C. E. Terrell et al.   BLOOD

Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients

(2013) Omer An et al.   PROTEIN SCIENCE

Human perforin mutations and susceptibility to multiple primary cancers

(2013) Joseph A. Trapani et al.   OncoImmunology

Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches

(2012) Nicola Marchi et al.   EPILEPSIA

CD8 T Cell-Initiated Blood-Brain Barrier Disruption Is Independent of Neutrophil Support

(2012) H. L. Johnson et al.   JOURNAL OF IMMUNOLOGY

Platelet-Activating Factor Receptor Is Essential for the Development of Experimental Cerebral Malaria

(2011) Norinne Lacerda-Queiroz et al.   AMERICAN JOURNAL OF PATHOLOGY

Perforin is a critical physiologic regulator of T-cell activation

(2011) J. E. Lykens et al.   BLOOD

Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures

(2011) Nicola Marchi et al.   EPILEPSIA

MRI in Rodent Models of Brain Disorders

(2011) Aleksandar Denic et al.   Neurotherapeutics

Theiler's Murine Encephalomyelitis Virus as a Vaccine Candidate for Immunotherapy

(2011) Kevin D. Pavelko et al.   PLoS One

Perforin deficiency and susceptibility to cancer

(2010) A J Brennan et al.   CELL DEATH AND DIFFERENTIATION

Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis

(2010) I. Pirko et al.   NEUROIMAGE

CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions

(2009) G. L. Suidan et al.   JOURNAL OF IMMUNOLOGY

Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function

(2008) R. Urrea Moreno et al.   BLOOD

Variations of the Perforin Gene in Patients With Type 1 Diabetes

(2008) E. Orilieri et al.   DIABETES

Acute hemorrhagic demyelination in a murine model of multiple sclerosis

(2008) Istvan Pirko et al.   Journal of Neuroinflammation

Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells

(2008) Georgette L. Suidan et al.   PLoS One

Multiple Sclerosis: Pathogenesis and MR Imaging Features of T1 Hypointensities in Murine Model

(2008) Istvan Pirko et al.   RADIOLOGY