LATE-NC staging in routine neuropathologic diagnosis: an update

Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis

(2022) Kathryn M. Gauthreaux et al.   NEUROLOGY

TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration

(2022) Marina Buciuc et al.   NeuroImage-Clinical

Developmental deficits and staging of dynamics of age associated Alzheimer’s disease neurodegeneration and neuronal loss in subjects with Down syndrome

(2022) Jerzy Wegiel et al.   Acta Neuropathologica Communications

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old

(2022) Shih-Hsiu J. Wang et al.   ACTA NEUROPATHOLOGICA

Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies

(2022) Matthew D. Cykowski et al.   ACTA NEUROPATHOLOGICA

Frequency and distribution of TAR DNA-binding protein 43 (TDP-43) pathology increase linearly with age in a large cohort of older adults with and without dementia

(2022) Arenn F. Carlos et al.   ACTA NEUROPATHOLOGICA

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration

(2022) Yuichi Riku et al.   BRAIN

DNAJB2 ‐related Charcot‐Marie‐Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening

(2022) Paola Saveri et al.   EUROPEAN JOURNAL OF NEUROLOGY

Patterns of Mixed Pathologies in Down Syndrome

(2022) Shojiro Ichimata et al.   JOURNAL OF ALZHEIMERS DISEASE

Parallel Appearance of Polyglutamine and Transactivation-Responsive DNA-Binding Protein 43 and Their Complementary Subcellular Localization in Brains of Patients With Spinocerebellar Ataxia Type 2

(2022) Shigeru Koyano et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TDP ‐43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease

(2022) Rika Yamashita et al.   MOVEMENT DISORDERS

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: An ex-vivo MRI and pathology investigation

(2022) Mahir Tazwar et al.   NEUROBIOLOGY OF AGING

A novel missense HNRNPA1 variant in the PY-NLS domain in a patient with late-onset distal myopathy

(2022) Pitcha Chompoopong et al.   NEUROMUSCULAR DISORDERS

Association of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons

(2022) Sonal Agrawal et al.   JAMA Network Open

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

(2022) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

Differential diagnosis of amnestic dementia patients based on an FDG‐PET signature of autopsy‐confirmed LATE‐NC

(2022) Michel J. Grothe et al.   Alzheimers & Dementia

TDP ‐43 Pathology Exacerbates Cognitive Decline in Primary Age‐Related Tauopathy

(2022) Denis S. Smirnov et al.   ANNALS OF NEUROLOGY

Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology

(2022) Aya Murakami et al.   BRAIN PATHOLOGY

Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+ Study

(2022) Zarui A. Melikyan et al.   NEUROBIOLOGY OF AGING

Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest-Old

(2022) Thomas J. Montine et al.   NEUROLOGY

Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old

(2022) Christian Lachner et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of glial tau pathology and LATE-NC in the ageing brain

(2022) Shelley L. Forrest et al.   NEUROBIOLOGY OF AGING

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

(2022) Marta J. Koper et al.   Acta Neuropathologica Communications

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

(2021) Johannes Attems et al.   ACTA NEUROPATHOLOGICA

To what degree is late life cognitive decline driven by age-related neuropathologies?

(2021) Patricia A Boyle et al.   BRAIN

Old age genetically confirmed frontotemporal lobar degeneration with TDP‐43 has limbic predominant TDP‐43 deposition

(2021) Marina Buciuc et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample

(2021) Nadia Postupna et al.   Frontiers in Neurology

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old

(2021) William T. Harrison et al.   ACTA NEUROPATHOLOGICA

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

(2021) Adam J. Dugan et al.   Acta Neuropathologica Communications

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease

(2021) Maiko T. Uemura et al.   ACTA NEUROPATHOLOGICA

Glial TDP‐43 and TDP‐43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes

(2021) Katherine E. Prater et al.   GLIA

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brain

(2021) Hans-Ulrich Klein et al.   Molecular Neurodegeneration

An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism–dementia complex

(2021) Yasumasa Kokubo et al.   NEUROLOGICAL SCIENCES

First Japanese autopsy case showing LRRK2 mutation G2019S and TDP-43 proteinopathy

(2021) Mayuko Sakuwa et al.   PARKINSONISM & RELATED DISORDERS

The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer’s dementia in older persons

(2021) Sonal Agrawal et al.   Acta Neuropathologica Communications

Myositis with sarcoplasmic inclusions in Nakajo‐Nishimura syndrome: a genetic inflammatory myopathy

(2020) Ayaki Takashi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy

(2020) Wendi Huang et al.   Frontiers in Molecular Neuroscience

TDP-43 Related Neuropathologies and Phosphorylation State: Associations with Age and Clinical Dementia in the Cambridge City over-75s Cohort

(2020) Sally Hunter et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct molecular patterns of TDP-43 pathology in Alzheimer’s disease: relationship with clinical phenotypes

(2020) Sandra O. Tomé et al.   Acta Neuropathologica Communications

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes

(2020) Manuela Neumann et al.   ACTA NEUROPATHOLOGICA

The influence of Aβ-dependent and independent pathways on TDP-43 proteinopathy in Alzheimer’s disease: a possible connection to LATE-NC

(2020) Angelo Jamerlan et al.   NEUROBIOLOGY OF AGING

Underlying genetic variation in familial frontotemporal dementia: sequencing of 198 patients

(2020) Merel O. Mol et al.   NEUROBIOLOGY OF AGING

Limbic-predominant age-related TDP-43 encephalopathy in black and white decedents

(2020) Sukriti Nag et al.   NEUROLOGY

Hippocampal sclerosis, TDP‐43, and the duration of the symptoms of dementia of AD patients

(2020) Oscar L. Lopez et al.   Annals of Clinical and Translational Neurology

Brain arteriolosclerosis

(2020) Brittney L. Blevins et al.   ACTA NEUROPATHOLOGICA

Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration

(2020) John L Robinson et al.   BRAIN

Concomitant LATE‐NC in Alzheimer's disease is not associated with increased tau or amyloid‐β pathological burden

(2020) K. E. McAleese et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Necrosome‐positive granulovacuolar degeneration is associated with TDP‐43 pathological lesions in the hippocampus of ALS/FTLD cases

(2020) E. Van Schoor et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

(2019) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy

(2019) Yevgen Chornenkyy et al.   LABORATORY INVESTIGATION

Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes

(2019) Yasushi Nishihira et al.   ACTA NEUROPATHOLOGICA

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels

(2019) Peter T. Nelson et al.   NEUROBIOLOGY OF DISEASE

LATE to the PART-y

(2019) Keith A Josephs et al.   BRAIN

Reply: LATE to the PART-y

(2019) Peter T Nelson et al.   BRAIN

Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

(2019) Caitlin S. Latimer et al.   Acta Neuropathologica Communications

Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases

(2019) Ian R. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Putative risk alleles for LATE‐NC with hippocampal sclerosis in population‐representative autopsy cohorts

(2019) Suvi R. K. Hokkanen et al.   BRAIN PATHOLOGY

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

Integrated neurodegenerative disease autopsy diagnosis

(2018) Edward B. Lee   ACTA NEUROPATHOLOGICA

Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study

(2018) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

Combined neuropathological pathways account for age-related risk of dementia

(2018) Melinda C. Power et al.   ANNALS OF NEUROLOGY

Hippocampal Sclerosis in the Oldest Old: A Finnish Population-Based Study

(2018) Mia Kero et al.   JOURNAL OF ALZHEIMERS DISEASE

Genotype–phenotype links in frontotemporal lobar degeneration

(2018) Sara Van Mossevelde et al.   Nature Reviews Neurology

TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer’s disease

(2018) Sukriti Nag et al.   Acta Neuropathologica Communications

Relative neuron loss in hippocampal sclerosis of aging and Alzheimer disease

(2018) Ryoko Ihara et al.   ANNALS OF NEUROLOGY

TDP-43 Pathology in the Population: Prevalence and Associations with Dementia and Age

(2018) Hannah A.D. Keage et al.   JOURNAL OF ALZHEIMERS DISEASE

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study

(2018) Margaret E. Flanagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Risk factors of hippocampal sclerosis in the oldest old

(2018) Thomas Trieu et al.   NEUROLOGY

Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy

(2018) Xiaoling Zhang et al.   Neuroscience Bulletin

Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer’s disease and cerebrovascular disease pathologies

(2018) Yuriko Katsumata et al.   Acta Neuropathologica Communications

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

(2017) Eseosa T. Ighodaro et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

(2017) Peter T Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD

(2017) Sukriti Nag et al.   NEUROLOGY

Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis

(2017) C. Nascimento et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Updated TDP-43 in Alzheimer’s disease staging scheme

(2016) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia

(2016) Bryan D. James et al.   BRAIN

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

(2015) Ann C. McKee et al.   ACTA NEUROPATHOLOGICA

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

(2015) Keith A. Josephs et al.   ANNALS OF NEUROLOGY

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

(2015) Sukriti Nag et al.   ANNALS OF NEUROLOGY

TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes

(2015) Rachel H. Tan et al.   BRAIN

Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample

(2015) Camila Nascimento et al.   BRAIN PATHOLOGY

Hippocampal Sclerosis of Aging Can Be Segmental

(2015) Eseosa T. Ighodaro et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TheTMEM106Blocus and TDP-43 pathology in older persons without FTLDAuthor Response

(2015) Dennis W. Dickson et al.   NEUROLOGY

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

(2015) Joery Goossens et al.   Acta Neuropathologica Communications

Incidence and extent of TDP-43 accumulation in aging human brain

(2015) Akiko Uchino et al.   Acta Neuropathologica Communications

Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A

(2014) Naoya Aoki et al.   ACTA NEUROPATHOLOGICA

Differential clinicopathologic and genetic features of late-onset amnestic dementias

(2014) Melissa E. Murray et al.   ACTA NEUROPATHOLOGICA

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium

(2014) Irina Alafuzoff et al.   JOURNAL OF NEURAL TRANSMISSION

Astrocytic TDP-43 Pathology in Alexander Disease

(2014) A. K. Walker et al.   JOURNAL OF NEUROSCIENCE

Significance and limitation of the pathological classification of TDP-43 proteinopathy

(2014) Tetsuaki Arai   NEUROPATHOLOGY

Unique Hard Scleral Lens Post-LASIK Ectasia Fitting

(2014) Rajeswari Mahadevan et al.   OPTOMETRY AND VISION SCIENCE

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

(2014) Linda K Kwong et al.   Acta Neuropathologica Communications

The neuropathology associated with repeat expansions in the C9ORF72 gene

(2013) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72

(2013) Melissa E. Murray et al.   ACTA NEUROPATHOLOGICA

TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies

(2013) Stacy J. Arnold et al.   ACTA NEUROPATHOLOGICA

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

(2013) Peter T. Nelson et al.   ACTA NEUROPATHOLOGICA

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Pathology of clinical and preclinical Alzheimer’s disease

(2013) Dietmar Rudolf Thal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample

(2012) Chris Zarow et al.   Brain and Behavior

Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans

(2011) Victoria E. Johnson et al.   ACTA NEUROPATHOLOGICA

Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress response

(2011) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype

(2011) Yvonne S. Davidson et al.   ACTA NEUROPATHOLOGICA

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Hippocampal Sclerosis in the Elderly

(2011) Winnie C. Pao et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Hippocampal sclerosis in advanced age: clinical and pathological features

(2011) Peter T. Nelson et al.   BRAIN

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness

(2010) Felix Geser et al.   ARCHIVES OF NEUROLOGY

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

(2010) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes

(2009) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

(2009) Tetsuaki Arai et al.   ACTA NEUROPATHOLOGICA

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

(2009) Manuela Neumann et al.   ACTA NEUROPATHOLOGICA

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

(2009) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Transactivation Response DNA-Binding Protein 43 Microvasculopathy in Frontotemporal Degeneration and Familial Lewy Body Disease

(2009) Wen-Lang Lin et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: Their relation to AD common pathology

(2009) Ai Kadokura et al.   NEUROPATHOLOGY

Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration

(2009) Ai Kadokura et al.   NEUROSCIENCE LETTERS

Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease

(2008) William T. Hu et al.   ACTA NEUROPATHOLOGICA

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

(2008) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

(2008) Lionel M. Igaz et al.   AMERICAN JOURNAL OF PATHOLOGY

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY

Hippocampal Sclerosis: Progress Since Sommer

(2008) Maria Thom   BRAIN PATHOLOGY

Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

Understanding hippocampal sclerosis in the elderly: Epidemiology, characterization, and diagnostic issues

(2008) Chris Zarow et al.   Current Neurology and Neuroscience Reports

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

(2008) Kunihiro Uryu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype

(2008) K. A. Josephs et al.   NEUROLOGY

Pallidonigral TDP-43 pathology in Perry syndrome

(2008) Christian Wider et al.   PARKINSONISM & RELATED DISORDERS