pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

(2022) Chen Zhang et al.   CHINESE CHEMICAL LETTERS

Anti‐inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K /Akt/ mTOR signaling pathway and regulating gut microbiota

(2022) Lingling Dong et al.   PHYTOTHERAPY RESEARCH

Natural compounds as safe therapeutic options for ulcerative colitis

(2022) Mukta Gupta et al.   INFLAMMOPHARMACOLOGY

ROS-responsive nanoparticles for oral delivery of luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment

(2022) Chen Tan et al.   Materials Today Bio

Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis

(2022) Chen Zhang et al.   MATERIALS & DESIGN

Deoxycholic acid-functionalised nanoparticles for oral delivery of rhein

(2021) Wenjie Yao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium

(2021) Shruti Ahlawat et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

(2021) Jian Fang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment

(2021) Qiyan Chen et al.   BIOMACROMOLECULES

Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment

(2021) Ruifeng Luo et al.   CARBOHYDRATE POLYMERS

Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein

(2021) Gang-Min Li et al.   Evidence-based Complementary and Alternative Medicine

Enhancement of oral bioavailability of natural compounds and probiotics by mucoadhesive tailored biopolymer-based nanoparticles: A review

(2021) M. Carmen Gómez-Guillén et al.   FOOD HYDROCOLLOIDS

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

(2021) Joana C. Antunes et al.   Marine Drugs

pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis

(2021) Haiting Xu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

(2021) Linshan Duan et al.   Frontiers in Pharmacology

Colon-targeted drug delivery of polysaccharide-based nanocarriers for synergistic treatment of inflammatory bowel disease: A review

(2021) Mingxiao Cui et al.   CARBOHYDRATE POLYMERS

β-1,3-d-Glucan based yeast cell wall system loaded emodin with dual-targeting layers for ulcerative colitis treatment

(2021) Xiulan Pu et al.   CARBOHYDRATE POLYMERS

Recent advances in polysaccharides from edible and medicinal Polygonati rhizoma: From bench to market

(2021) Yanan He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mucoadhesive and pH responsive fucoidan-chitosan nanoparticles for the oral delivery of methotrexate

(2020) Ana J. Coutinho et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases

(2020) Marta Piotrowska et al.   PHARMACOLOGICAL RESEARCH

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy

(2020) Eden Mariam Jacob et al.   Nanomaterials

Application of pH-Responsive Fucoidan/Chitosan Nanoparticles to Improve Oral Quercetin Delivery

(2019) Ana Barbosa et al.   MOLECULES

Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells

(2019) Shen Zhuang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives

(2019) Chunhua Yang et al.   International Journal of Nanomedicine

Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

(2019) Ana Isabel Barbosa et al.   Marine Drugs

Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs

(2018) Chien-Ho Chen et al.   CARBOHYDRATE POLYMERS

Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases

(2018) Qijuan Sun et al.   CARBOHYDRATE POLYMERS

pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease

(2018) Serena Bertoni et al.   ADVANCED FUNCTIONAL MATERIALS

Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs

(2018) Shen Zhuang et al.   LIFE SCIENCES

Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin

(2018) Li-Chu Tsai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro

(2017) Hui Ge et al.   Drug Design Development and Therapy

O-carboxymethyl chitosan/fucoidan nanoparticles increase cellular curcumin uptake

(2016) Yi-Cheng Huang et al.   FOOD HYDROCOLLOIDS

Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery

(2016) Lin Zhang et al.   JOURNAL OF DRUG TARGETING

Marine Origin Polysaccharides in Drug Delivery Systems

(2016) Matias Cardoso et al.   Marine Drugs

A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient

(2016) Hao Sun et al.   Frontiers in Pharmacology

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

(2015) Ana C. Pinheiro et al.   CARBOHYDRATE POLYMERS

Polymeric nanoparticle drug delivery technologies for oral delivery applications

(2015) Eric M Pridgen et al.   Expert Opinion on Drug Delivery

Clinical Practice Guidelines for the Medical Management of Nonhospitalized Ulcerative Colitis: The Toronto Consensus

(2015) Brian Bressler et al.   GASTROENTEROLOGY

Relative charge density model on chitosan–fucoidan electrostatic interaction: Qualitative approach with element analysis

(2015) Eun Ju Lee et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery

(2015) Xinhua Gu et al.   Drug Design Development and Therapy

Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract

(2013) Wenjin Wu et al.   BIOMEDICAL CHROMATOGRAPHY

Advances in chitosan-based drug delivery vehicles

(2013) Liming Hu et al.   Nanoscale

Effects of rhein on intestinal epithelial tight junction in IgA nephropathy

(2013) Sheng-Nan Peng   WORLD JOURNAL OF GASTROENTEROLOGY

Chitosan-based drug nanocarriers: Where do we stand?

(2012) Marcos Garcia-Fuentes et al.   JOURNAL OF CONTROLLED RELEASE

A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics

(2010) Kyle E. Broaders et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY