Magel2knockdown in hypothalamic POMC neurons innervating the medial amygdala reduces susceptibility to diet-induced obesity

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

(2021) Giles S.H. Yeo et al.   Molecular Metabolism

Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting

(2021) Nasim Biglari et al.   NATURE NEUROSCIENCE

The Antitumor Peptide ERα17p Exerts Anti-Hyperalgesic and Anti-Inflammatory Actions Through GPER in Mice

(2021) Christophe Mallet et al.   Frontiers in Endocrinology

Oestrogen engages brain MC4R signalling to drive physical activity in female mice

(2021) William C. Krause et al.   NATURE

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

(2020) Geetanjali Sharma et al.   Science Translational Medicine

G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic

(2020) Marilena Marraudino et al.   NEUROENDOCRINOLOGY

G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus

(2020) Ricardo Llorente et al.   Frontiers in Endocrinology

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production

(2020) Helen Chen et al.   JCI Insight

Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

(2020) Eunjin Kwon et al.   Nature Communications

Causes of death in Prader-Willi syndrome: lessons from 11 years’ experience of a national reference center

(2019) Dibia Liz Pacoricona Alfaro et al.   Orphanet Journal of Rare Diseases

CalR : A Web-Based Analysis Tool for Indirect Calorimetry Experiments

(2018) Amir I. Mina et al.   Cell Metabolism

Impaired melanocortin pathway function in Prader–Willi syndrome gene-Magel2 deficient mice

(2018) Merve Oncul et al.   HUMAN MOLECULAR GENETICS

Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

(2018) Jae Hoon Jeong et al.   PLOS BIOLOGY

Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding

(2018) Qiang Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Imaging Provides Novel Insights on Estrogen Receptor Activity in Mouse Brain

(2018) Alessia Stell et al.   Molecular Imaging

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

(2018) Benjamin P. Tooke et al.   Molecular Metabolism

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

(2017) Brian Y.H. Lam et al.   Molecular Metabolism

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits

(2016) Julien Maillard et al.   HUMAN MOLECULAR GENETICS

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

(2016) Lisa C. Burnett et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus

(2016) Jae Hoon Jeong et al.   PLoS One

Snord116 is critical in the regulation of food intake and body weight

(2016) Yue Qi et al.   Scientific Reports

Conditional Expression ofPomcin theLepr-Positive Subpopulation of POMC Neurons Is Sufficient for Normal Energy Homeostasis and Metabolism

(2015) Daniel D. Lam et al.   ENDOCRINOLOGY

Estrogen receptor–α in medial amygdala neurons regulates body weight

(2015) Pingwen Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons

(2015) Dong Kun Lee et al.   Nature Communications

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

(2015) Daqing Wang et al.   Frontiers in Neuroanatomy

Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

(2015) Marc Schneeberger et al.   Cell Reports

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

(2015) Fredrick E Henry et al.   eLife

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

(2015) Jae Hoon Jeong et al.   Molecular Metabolism

MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

(2014) B. P. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Recommendations for the investigation of animal models of Prader–Willi syndrome

(2013) James L. Resnick et al.   MAMMALIAN GENOME

Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior

(2013) Yona Greenman et al.   MOLECULAR ENDOCRINOLOGY

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice

(2013) Rebecca E. Mercer et al.   PLoS Genetics

Prader-Willi syndrome

(2012) Suzanne B. Cassidy et al.   GENETICS IN MEDICINE

Obesity-programmed mice are rescued by early genetic intervention

(2012) Viviana F. Bumaschny et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of GABA and Glutamate Release from Proopiomelanocortin Neuron Terminals in Intact Hypothalamic Networks

(2012) M. S. Dicken et al.   JOURNAL OF NEUROSCIENCE

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

(2011) Yong Xu et al.   Cell Metabolism

Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion

(2011) Jing Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The G-protein-coupled estrogen receptor GPER in health and disease

(2011) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

Relative Number and Distribution of Murine Hypothalamic Proopiomelanocortin Neurons Innervating Distinct Target Sites

(2011) Connie M. King et al.   PLoS One

Dilation of Epicardial Coronary Arteries by the G Protein-Coupled Estrogen Receptor Agonists G-1 and ICI 182,780

(2010) Matthias R. Meyer et al.   PHARMACOLOGY

Estrogen Masculinizes Neural Pathways and Sex-Specific Behaviors

(2009) Melody V. Wu et al.   CELL

Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents

(2009) Nicholas Wallingford et al.   JOURNAL OF CLINICAL INVESTIGATION

Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues

(2009) Georgina G J Hazell et al.   JOURNAL OF ENDOCRINOLOGY

Loss of Magel2, a Candidate Gene for Features of Prader-Willi Syndrome, Impairs Reproductive Function in Mice

(2009) Rebecca E. Mercer et al.   PLoS One

Central estrogen inhibition of angiotensin II-induced hypertension in male mice and the role of reactive oxygen species

(2008) Baojian Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice

(2008) Feng Ding et al.   PLoS One