Multivalent binding kinetics resolved by fluorescence proximity sensing

Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2

(2022) Genwei Zhang et al.   Communications Chemistry

A Versatile Synthetic Affinity Probe Reveals Inhibitory Synapse Ultrastructure and Brain Connectivity**

(2022) Vladimir Khayenko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Binding Revisited—Avidity in Cellular Function and Signaling

(2021) Simon Erlendsson et al.   Frontiers in Molecular Biosciences

Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics

(2021) Julian A. C. Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding GABAAR pharmacology via receptor-associated proteins

(2021) Clemens Schulte et al.   CURRENT OPINION IN PHARMACOLOGY

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

(2021) Florian Kast et al.   Nature Communications

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

(2021) Satomi Imaide et al.   Nature Chemical Biology

Probing Multivalent Carbohydrate-Protein Interactions With On-Chip Synthesized Glycopeptides Using Different Functionalized Surfaces

(2021) Alexandra Tsouka et al.   Frontiers in Chemistry

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics

(2020) Julius Wiener et al.   Scientific Reports

Resolving Binding Events on the Multifunctional Human Serum Albumin

(2020) Lea Wenskowsky et al.   ChemMedChem

High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale

(2020) Clemens Schulte et al.   iScience

Encodings and models for antimicrobial peptide classification for multi-resistant pathogens

(2019) Sebastian Spänig et al.   BioData Mining

A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding

(2019) Irene Ponzo et al.   MOLECULES

Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

(2019) Wesley J. Errington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iFeature: a Python package and web server for features extraction and selection from protein and peptide sequences

(2018) Zhen Chen et al.   BIOINFORMATICS

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

(2016) Hans Michael Maric et al.   Nature Chemical Biology

Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

(2016) Chad A Brautigam et al.   Nature Protocols

Modulation of Gephyrin-Glycine Receptor Affinity by Multivalency

(2014) Hans Michael Maric et al.   ACS Chemical Biology

Gephyrin: a master regulator of neuronal function?

(2014) Shiva K. Tyagarajan et al.   NATURE REVIEWS NEUROSCIENCE

Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin

(2014) Hans Michael Maric et al.   Nature Communications

Surface plasmon resonance spectroscopy for characterisation of membrane protein–ligand interactions and its potential for drug discovery

(2013) Simon G. Patching   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Druggable protein–protein interactions – from hot spots to hot segments

(2013) Nir London et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein analysis by time-resolved measurements with an electro-switchable DNA chip

(2013) Andreas Langer et al.   Nature Communications

Snakemake--a scalable bioinformatics workflow engine

(2012) J. Koster et al.   BIOINFORMATICS

Quantitation of Affinity, Avidity, and Binding Kinetics of Protein Analytes with a Dynamically Switchable Biosurface

(2012) Jelena Knezevic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

(2012) A. Bach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4

(2011) Oliver Demmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deciphering the Kinetic Binding Mechanism of Dimeric Ligands Using a Potent Plasma-stable Dimeric Inhibitor of Postsynaptic Density Protein-95 as an Example

(2010) Celestine N. Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformations of End-Tethered DNA Molecules on Gold Surfaces: Influences of Applied Electric Potential, Electrolyte Screening, and Temperature

(2010) Wolfgang Kaiser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tricks with tetramers: how to get the most from multimeric peptide-MHC

(2009) Linda Wooldridge et al.   IMMUNOLOGY

A General Screening Strategy for Peptide-Based Fluorogenic Ligands: Probes for Dynamic Studies of PDZ Domain-Mediated Interactions

(2009) Matthieu Sainlos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY