Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases

Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer’s disease

(2017) Nan Zhang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Impairment of intradimensional shift in an attentional set-shifting task in rats with chronic bilateral common carotid artery occlusion

(2016) Dong-Hee Kim et al.   BEHAVIOURAL BRAIN RESEARCH

Study on cerebroprotective actions of Clerodendron glandulosum leaves extract against long term bilateral common carotid artery occlusion in rats

(2016) Saritha Surapaneni et al.   BIOMEDICINE & PHARMACOTHERAPY

Subtle learning and memory impairment in an idiopathic rat model of Alzheimer's disease utilizing cholinergic depletions and β-amyloid

(2016) S.H. Deibel et al.   BRAIN RESEARCH

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

(2016) Chelsea C. Hays et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Strong Impact of Chronic Cerebral Hypoperfusion on Neurovascular Unit, Cerebrovascular Remodeling, and Neurovascular Trophic Coupling in Alzheimer’s Disease Model Mouse

(2016) Jingwei Shang et al.   JOURNAL OF ALZHEIMERS DISEASE

Disruption of White Matter Integrity by Chronic Cerebral Hypoperfusion in Alzheimer’s Disease Mouse Model

(2016) Yun Zhai et al.   JOURNAL OF ALZHEIMERS DISEASE

Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway

(2016) Carolyn L. Fisher et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Cerebral Hypoperfusion Accelerates Alzheimer’s Disease Pathology with Cerebrovascular Remodeling in a Novel Mouse Model

(2016) Yun Zhai et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease

(2016) Noboru Toda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Rhizophora mucronata attenuates beta-amyloid induced cognitive dysfunction, oxidative stress and cholinergic deficit in Alzheimer’s disease animal model

(2016) Natarajan Suganthy et al.   METABOLIC BRAIN DISEASE

Relationship between white matter lesions and regional cerebral blood flow changes during longitudinal follow up in Alzheimer's disease

(2015) Takuya Hanaoka et al.   Geriatrics & Gerontology International

Ischemic brain injury in cerebral amyloid angiopathy

(2015) Yael D Reijmer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study

(2015) Xuxia Wang et al.   MAGNETIC RESONANCE IMAGING

Satureja bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer’s disease

(2015) Maliheh Soodi et al.   METABOLIC BRAIN DISEASE

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Lamotrigine attenuates cerebral ischemia-induced cognitive impairment and decreases β-amyloid and phosphorylated tau in the hippocampus in rats

(2015) Huanhuan Han et al.   NEUROREPORT

Cerebral Blood Flow is an Earlier Indicator of Perfusion Abnormalities than Cerebral Blood Volume in Alzheimer's Disease

(2014) María Lacalle-Aurioles et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia

(2014) Yingxiang Huang et al.   NEURO-OPHTHALMOLOGY

Altered expression of neurofilament 200 and amyloid-β peptide (1–40) in a rat model of chronic cerebral hypoperfusion

(2014) Weihua Liang et al.   NEUROLOGICAL SCIENCES

Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice

(2014) Angélica Pupin Schiavon et al.   NEUROTOXICITY RESEARCH

Bladder dysfunction induced by cerebral hypoperfusion after bilateral common carotid artery occlusion in rats

(2014) Ching-Chung Liang et al.   NEUROUROLOGY AND URODYNAMICS

Serum β-Amyloid Peptide Levels Spike in the Early Stage of Alzheimer- Like Plaque Pathology in an APP/PS1 Double Transgenic Mouse Model

(2013) Jue He et al.   Current Alzheimer Research

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

(2013) Carolyn C. Sachse et al.   FASEB JOURNAL

Cilostazol Inhibits Platelet–Endothelial Cell Interaction in Murine Microvessels after Transient Bilateral Common Carotid Artery Occlusion

(2013) Takuya Fukuoka et al.   Journal of Stroke & Cerebrovascular Diseases

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation

(2013) Ayman ElAli et al.   Acta Neuropathologica Communications

Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography

(2012) Kuo-Lun Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice

(2012) Pedro M. Pimentel-Coelho et al.   NEUROBIOLOGY OF AGING

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

(2011) Bryan Maloney et al.   GENE

Matrix metalloproteinase-9 and non-amyloidogenic pathway of amyloid precursor protein processing

(2011) Mikhail A. Filippov et al.   JOURNAL OF NEUROCHEMISTRY

Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

(2011) Mayu MUTSUGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase

(2011) Sebastian Hogl et al.   PLoS One

Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: An additional contributing factor of cognitive impairment

(2010) Jin Soo Lee et al.   NEUROSCIENCE LETTERS

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

(2009) Cai Zhiyou et al.   NEUROCHEMICAL RESEARCH

Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease

(2008) Jonghan Shin et al.   NEUROIMAGE