Outer Membrane Vesicles: An Emerging Vaccine Platform

Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune Responses

(2021) J. Timothy Prior et al.   Pharmaceutics

The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients

(2021) Andrii Rabets et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

(2021) Keman Cheng et al.   Nature Communications

Experimental studies using OMV in a new platform of SARS-CoV-2 vaccines

(2021) Emanuelle B. Gaspar et al.   Human Vaccines & Immunotherapeutics

Another Decade, Another Coronavirus

(2020) Stanley Perlman   NEW ENGLAND JOURNAL OF MEDICINE

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

(2020) Lydia Durant et al.   Microbiome

Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms

(2020) Ruizhen Li et al.   Frontiers in Materials

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

(2019) Khalid O. Alfarouk et al.   Frontiers in Oncology

Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages

(2019) Eun-Hye Bae et al.   Journal of Innate Immunity

A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains

(2019) María Eugenia Zurita et al.   Frontiers in Cellular and Infection Microbiology

Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

(2019) Sjoerd T.T. Schetters et al.   Acta Biomaterialia

Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV

(2019) Mahmoud M. Shehata et al.   Vaccines

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood–brain barrier in mice

(2019) Eun-Chong Han et al.   FASEB JOURNAL

Spontaneously released Neisseria meningitidis outer membrane vesicles as vaccine platform: production and purification

(2019) Matthias J.H. Gerritzen et al.   VACCINE

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

(2019) Laurence Macia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immediate response mechanisms of Gram-negative solvent-tolerant bacteria to cope with environmental stress: cis-trans isomerization of unsaturated fatty acids and outer membrane vesicle secretion

(2018) Christian Eberlein et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Bam complex catalyzes efficient insertion of bacterial outer membrane proteins into membrane vesicles of variable lipid composition

(2018) Sunyia Hussain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outer Membrane Vesicles from Neisseria Meningitidis (Proteossome) Used for Nanostructured Zika Virus Vaccine Production

(2018) Paula Martins et al.   Scientific Reports

Outer Membrane Vesicles: Current Status and Future Direction of These Novel Vaccine Adjuvants

(2018) Kuang Tan et al.   Frontiers in Microbiology

Helicobacter pylori Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content

(2018) Lorinda Turner et al.   Frontiers in Immunology

Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based

(2018) Wei Cai et al.   Diagnostic Pathology

The Therapeutic Benefit of Bacterial Membrane Vesicles

(2017) Natalie Bitto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Outer Membrane Vesicles (OMVs) of Gram-negative Bacteria: A Perspective Update

(2017) Arif Tasleem Jan   Frontiers in Microbiology

Novel approaches to Neisseria meningitidis vaccine design

(2017) Myron Christodoulides et al.   Pathogens and Disease

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

(2017) Anna Lena Jung et al.   Jove-Journal of Visualized Experiments

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR–IκB Kinase–NF-κB Pathways in Dendritic Cells

(2016) Su Hyuk Ko et al.   INFECTION AND IMMUNITY

Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies

(2016) Linxiao Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the immune response induced by pertussis OMVs-based vaccine

(2016) D. Bottero et al.   VACCINE

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria

(2016) Sandro Roier et al.   Nature Communications

Protecting enzymatic function through directed packaging into bacterial outer membrane vesicles

(2016) Nathan J. Alves et al.   Scientific Reports

Outer membrane vesicles as platform vaccine technology

(2015) Leo van der Pol et al.   Biotechnology Journal

Methods of isolation and purification of outer membrane vesicles from gram-negative bacteria

(2015) Jana Klimentová et al.   MICROBIOLOGICAL RESEARCH

Outer membrane vesicles as platform vaccine technology

(2015) Leo van der Pol et al.   Biotechnology Journal

Gene Transfer Potential of Outer Membrane Vesicles of Acinetobacter baylyi and Effects of Stress on Vesiculation

(2014) Shweta Fulsundar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Glycans in pathogenic bacteria – potential for targeted covalent therapeutics and imaging agents

(2014) Van N. Tra et al.   CHEMICAL COMMUNICATIONS

Modulation of Endotoxicity ofShigellaGeneralized Modules for Membrane Antigens (GMMA) by Genetic Lipid A Modifications

(2014) Omar Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive proteomic profiling of outer membrane vesicles from Campylobacter jejuni

(2014) Kyoung-Soon Jang et al.   Journal of Proteomics

Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria

(2014) H. M. Kulkarni et al.   MICROBIOLOGY-SGM

Outer membrane vesicles ofPasteurella multocidacontain virulence factors

(2014) Miguel A. Fernández-Rojas et al.   MicrobiologyOpen

Bacterial Outer Membrane Vesicles and Vaccine Applications

(2014) Reinaldo Acevedo et al.   Frontiers in Immunology

Protein selection and export via outer membrane vesicles

(2013) K.E. Bonnington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Lung Tissue Explants Reveal Novel Interactions during Legionella pneumophila Infections

(2013) Jens Jäger et al.   INFECTION AND IMMUNITY

Immunization with Escherichia coli Outer Membrane Vesicles Protects Bacteria-Induced Lethality via Th1 and Th17 Cell Responses

(2013) O. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Preclinical immunogenicity and functional activity studies of an A+W meningococcal outer membrane vesicle (OMV) vaccine and comparisons with existing meningococcal conjugate- and polysaccharide vaccines

(2013) G. Tunheim et al.   VACCINE

Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): Lessons from past programs and implications for the future

(2013) Johan Holst et al.   Human Vaccines & Immunotherapeutics

Membrane Vesicle Formation as a Multiple-Stress Response Mechanism Enhances Pseudomonas putida DOT-T1E Cell Surface Hydrophobicity and Biofilm Formation

(2012) Thomas Baumgarten et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Application of Outer Membrane Vesicle of Neisseria meningitidis Serogroup B as a New Adjuvant to Induce Strongly Th1-Oriented Responses Against HIV-1

(2012) Mohammad Reza Aghasadeghi et al.   CURRENT HIV RESEARCH

Campylobacter jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial Cells

(2012) Abdi Elmi et al.   INFECTION AND IMMUNITY

Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles

(2011) Rostyslav O. Bilyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition and function of Helicobacter pylori outer membrane vesicles

(2011) Heather Parker et al.   MICROBES AND INFECTION

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming

(2011) Dong Ho Lee et al.   VACCINE

Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles

(2010) Adam Kulp et al.   Annual Review of Microbiology

Review of Meningococcal Group B Vaccines

(2010) Dan M. Granoff   CLINICAL INFECTIOUS DISEASES

Immunization withSalmonella entericaSerovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge withStreptococcus pneumoniae

(2010) Maneesha Muralinath et al.   INFECTION AND IMMUNITY

Biochemical and functional characterization of Helicobacter pylori vesicles

(2010) Annelie Olofsson et al.   MOLECULAR MICROBIOLOGY

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

(2010) Maria Laura A. Perez Vidakovics et al.   PLoS Pathogens

Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments

(2009) N. Furuta et al.   INFECTION AND IMMUNITY

Absence of Mucosal Immunity in the Human Upper Respiratory Tract to the Commensal Bacteria Neisseria lactamica but Not Pathogenic Neisseria meningitidis during the Peak Age of Nasopharyngeal Carriage

(2009) A. T. Vaughan et al.   JOURNAL OF IMMUNOLOGY

Self-adjuvant and immune-stimulating activity of the anti-meningococcus B vaccine candidate Neisseria Meningitidis adhesin A as a soluble recombinant antigen (NadAΔ351–405) or as part of bacterial outer membrane vesicles

(2009) R. Tavano et al.   New Biotechnology

Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogenHelicobacter pylori

(2009) Erica Mullaney et al.   Proteomics Clinical Applications

Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis

(2009) Johan Holst et al.   VACCINE

In vivovirulence properties of bacterial cytolethal-distending toxin

(2008) Zhongming Ge et al.   CELLULAR MICROBIOLOGY

Characterization of Vibrio cholerae Outer Membrane Vesicles as a Candidate Vaccine for Cholera

(2008) S. Schild et al.   INFECTION AND IMMUNITY

Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis

(2007) Sabine Siegemund et al.   IMMUNOBIOLOGY