Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment

Disentangling glial diversity in peripheral nerves at single-nuclei resolution

(2022) Aldrin K. Y. Yim et al.   NATURE NEUROSCIENCE

Periostin-expressing Schwann cells and endoneurial cardiac fibroblasts contribute to sympathetic nerve fasciculation after birth

(2021) Luis Hortells et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)

(2021) Daniel Gerber et al.   eLife

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

(2020) Hamad Alshetaiwi et al.   Science Immunology

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

(2020) Elke Ydens et al.   NATURE NEUROSCIENCE

Selumetinib in Children with Inoperable Plexiform Neurofibromas

(2020) Andrea M. Gross et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair

(2020) Laura Farr et al.   Frontiers in Immunology

Satellite glial cells promote regenerative growth in sensory neurons

(2020) Oshri Avraham et al.   Nature Communications

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

(2020) Ashley L Kalinski et al.   eLife

Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves

(2019) Kristjan R. Jessen et al.   Frontiers in Molecular Neuroscience

Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers

(2019) Zhe Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing

(2019) Sara Waise et al.   Scientific Reports

Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus

(2019) Joshua B. Bilsborrow et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes

(2019) Erica A K DePasquale et al.   NUCLEIC ACIDS RESEARCH

NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation

(2019) Yanan Yu et al.   ACTA NEUROPATHOLOGICA

Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target

(2019) Panagiota S. Filippou et al.   ONCOGENE

Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

(2018) Chung-Ping Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Schwann cell–derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment

(2018) Denise E. Allard et al.   JOURNAL OF CLINICAL INVESTIGATION

Ras-Specific GTPase-Activating Proteins—Structures, Mechanisms, and Interactions

(2018) Klaus Scheffzek et al.   Cold Spring Harbor Perspectives in Medicine

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma

(2018) Jonathan S. Fletcher et al.   ONCOGENE

Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells

(2018) Katarzyna J. Radomska et al.   Cancer Discovery

Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1—a consensus overview

(2017) Markku M. Miettinen et al.   HUMAN PATHOLOGY

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas

(2017) A Pemov et al.   ONCOGENE

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system

(2017) Kwangmin Choi et al.   Scientific Reports

The biological function and significance of CD74 in immune diseases

(2016) Huiting Su et al.   INFLAMMATION RESEARCH

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas

(2016) Eva Dombi et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD74 is a novel transcription regulator

(2016) Naama Gil-Yarom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

(2016) Michael G. Poulos et al.   Nature Communications

The role of nerve microenvironment for neurofibroma development

(2016) Chung-Ping Liao et al.   Oncotarget

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

(2016) Jianqiang Wu et al.   Cell Reports

The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma

(2015) Beth A. Christian et al.   BRITISH JOURNAL OF HAEMATOLOGY

Incidence and Mortality of Neurofibromatosis: A Total Population Study in Finland

(2015) Elina Uusitalo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1

(2015) Edwin Jousma et al.   PEDIATRIC BLOOD & CANCER

Soluble AXL: A Possible Circulating Biomarker for Neurofibromatosis Type 1 Related Tumor Burden

(2015) Gunnar Johansson et al.   PLoS One

Midkine in repair of the injured nervous system

(2014) Yoshihiro Yoshida et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma

(2014) Zhiguo Chen et al.   CANCER CELL

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition

(2012) Carlos E. Prada et al.   ACTA NEUROPATHOLOGICA

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors

(2012) Walter J. Jessen et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Assessment of Whole-Body Tumor Burden in Adult Patients with Neurofibromatosis

(2012) Scott R. Plotkin et al.   PLoS One

Pathogenesis of Plexiform Neurofibroma: Tumor-Stromal/Hematopoietic Interactions in Tumor Progression

(2011) Karl Staser et al.   Annual Review of Pathology-Mechanisms of Disease

The structure of the perineuronal sheath of satellite glial cells (SGCs) in sensory ganglia

(2010) Ennio Pannese   Neuron Glia Biology

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Disruption of Fibroblast Growth Factor Receptor Signaling in Nonmyelinating Schwann Cells Causes Sensory Axonal Neuropathy and Impairment of Thermal Pain Sensitivity

(2009) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Neurofibroma development in NF1 – insights into tumour initiation

(2009) Simona Parrinello et al.   TRENDS IN CELL BIOLOGY

CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

(2009) Ellen J Beswick et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Induction of Abnormal Proliferation by Nonmyelinating Schwann Cells Triggers Neurofibroma Formation

(2008) Huarui Zheng et al.   CANCER CELL

Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells

(2008) Jianqiang Wu et al.   CANCER CELL

Nf1 Mutation Expands an EGFR-Dependent Peripheral Nerve Progenitor that Confers Neurofibroma Tumorigenic Potential

(2008) Jon P. Williams et al.   Cell Stem Cell