Review
Immunology
Guoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong, Liangxue Zhou
Summary: This review discusses the characteristics and functions of TAMs in GBM, and evaluates the current state of TAMs-targeting strategies. TAMs are logical therapeutic targets for GBM, and understanding how TAMs promote GBM progression is of great significance for new immune therapeutic approaches for GBM patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Chao Lin, Ning Wang, Chengyan Xu
Summary: Glioma is a solid tumor composed of both neoplastic and non-neoplastic components. Glioma-associated macrophages and microglia (GAMs) are crucial in regulating tumor growth, invasion, and recurrence in the glioma tumor microenvironment. This review provides an overview of the intricate relationship between GAMs and the glioma tumor microenvironment, as well as a summary of immunotherapies targeting GAMs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Maricruz Rivera, Evan D. Bander, Babacar Cisse
Summary: Glioblastoma is the most aggressive primary tumor of the central nervous system with poor prognosis. Understanding the immune system's effects on glioma growth, invasion, survival, and angiogenesis is crucial for immunotherapy target development. Current clinical trials are investigating various approaches targeting the tumor microenvironment, as well as using vaccines, oncolytic viruses, antibodies, and chimeric antigen receptor T cells for treating glioma cells.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Mengxian Jia, Wenbin Zhang, Junle Zhu, Changgang Huang, Jian Zhou, Jiashu Lian, Ying Wang, Honglin Teng, Zhihui Huang
Summary: The study showed that HEXA and HEXB were significantly upregulated in GBM patients, specifically in microglia, and their expression inhibited the proliferation and migration of GBM cells. Higher expression of HEXA and HEXB was associated with poor prognosis in GBM patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Review
Immunology
Casper J. Pachocki, Elly M. Hol
Summary: DMG is a highly malignant pediatric brain tumor with a near-zero survival rate. Recent advances in research have revealed that DMG and GBM are distinct disease entities, with separate tissue characteristics and genetic profiles. DMG has a unique immune microenvironment, characterized by low levels of immune cell infiltration, inflammation, and immunosuppression that may impact disease development and outcome.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Oncology
Gianluca Trevisi, Annunziato Mangiola
Summary: In this manuscript, the authors review the biological characteristics of glioblastoma peritumoral tissue and emphasize its importance in glioblastoma progression and recurrence. The peritumoral brain zone (PBZ) is the primary target for post-operative adjuvant treatment, and understanding its unique microenvironment and cellular landscape is crucial for developing more effective treatments.
Article
Medicine, Research & Experimental
Apeng Chen, Yinan Jiang, Zhengwei Li, Lingxiang Wu, Ulises Santiago, Han Zou, Chunhui Cai, Vaibhav Sharma, Yongchang Guan, Lauren H. McCarl, Jie Ma, Yijen L. Wu, Joshua Michel, Yi Shi, Liza Konnikova, Nduka M. Amankulor, Pascal O. Zinn, Gary Kohanbash, Sameer Agnihotri, Songjian Lu, Xinghua Lu, Dandan Sun, George K. Gittes, Qianghu Wang, Xiangwei Xiao, Dean Yimlamai, Ian F. Pollack, Carlos J. Camacho, Baoli Hu
Summary: The CHI3L1 signaling pathway plays a crucial role in modulating the immune suppression microenvironment in glioblastoma by affecting tumor-associated macrophages. Gal3BP competes with Gal3 to bind CHI3L1, thus negatively regulating the immune evasion process. Administering a Gal3BP mimetic peptide in mouse models can reverse immune suppression and slow tumor progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Kunshan He, Chongwei Chi, Deling Li, Jingjing Zhang, Gang Niu, Fangqiao Lv, Junmei Wang, Wenqiang Che, Liwei Zhang, Nan Ji, Zhaohui Zhu, Jie Tian, Xiaoyuan Chen
Summary: The GBM-specific fluorescent IRDye800-BBN achieved a complete resection rate of 82.76% in 29 GBM patients, with a sensitivity and specificity of 94.44% and 88.24%, respectively. This specific fluorescence may help neurosurgeons accurately identify tumor boundaries and potentially improve patient survival outcomes.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Nian Chen, Cheng Peng, Dan Li
Summary: Glioblastoma (GBM) is the most common malignant brain tumor in adults. The inflammatory microenvironment accelerates epigenetic changes in GBM and helps tumors evade immune surveillance. GBM tumor cells and glioma-associated microglia/macrophages are the primary contributors, and the modification of epigenetic events exacerbates the proliferation, invasion, and migration of GBM. Certain drugs can reverse the inflammatory environment and inhibit GBM growth and invasion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Junhui Liu, Lun Gao, Xiaonan Zhu, Rongxin Geng, Xiang Tao, Haitao Xu, Zhibiao Chen
Summary: The study revealed that GSDMD expression was upregulated in glioma, significantly associated with WHO grade IV, IDH 1/2 wild-type, and mesenchymal subtypes, as well as shorter overall survival. GSDMD may participate in regulating macrophage infiltration and polarization, serving as a prognostic biomarker and TMZ-treatment response marker in glioma.
Article
Allergy
Aurelie Poli, Anais Oudin, Arnaud Muller, Ilaria Salvato, Andrea Scafidi, Oliver Hunewald, Olivia Domingues, Petr Nazarov, Vincent Puard, Virginie Baus, Francisco Azuaje, Gunnar Dittmar, Jacques Zimmer, Tatiana Michel, Alessandro Michelucci, Simone P. Niclou, Markus Ollert
Summary: Allergic airway inflammation delays tumor growth and improves survival in a mouse model of glioblastoma by modulating microglial gene expression and enhancing adaptive immunity.
Article
Biochemistry & Molecular Biology
Yao-Feng Li, Wen-Chiuan Tsai, Chung-Hsing Chou, Li-Chun Huang, Shih-Ming Huang, Dueng-Yuan Hueng, Chia-Kuang Tsai
Summary: Despite advances in diagnosis and treatment, overall survival for glioma patients remains poor. The study found that CKAP2L expression correlates with tumor grade and overall survival in glioma patients. Knockdown of CKAP2L inhibits glioma cell proliferation, migration, invasion, and induces cell cycle arrest at G2/M phase; it is also a vital regulator of miR-4496 activity and a potentially useful prognostic marker in glioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Alessandra De Leo, Alessio Ugolini, Filippo Veglia
Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.
Article
Neurosciences
Assunta Virtuoso, Ciro De Luca, Giovanni Cirillo, Matteo Riva, Gabriele Romano, Angela Bentivegna, Marialuisa Lavitrano, Michele Papa, Roberto Giovannoni
Summary: This study characterized the time-related changes in the GBM landscape using a mouse model, finding that the tumor formed a bulk at 14 days and was surrounded by reactive astrocytes. The recruitment of microglia/macrophages and antigen-presenting functions were impaired during GBM progression, while changes in the extracellular matrix were observed during the invasive phase.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Genetics & Heredity
Chao Qin, Xiaoyan He, Yanding Zhao, Chun-Yip Tong, Kenneth Y. Zhu, Yongqi Sun, Chao Cheng
BMC MEDICAL GENOMICS
(2019)
Review
Biochemistry & Molecular Biology
Kong Y. Chen, Robert J. Brychta, Zahraa Abdul Sater, Thomas M. Cassimatis, Cheryl Cero, Laura A. Fletcher, Nikita S. Israni, James W. Johnson, Hannah J. Lea, Joyce D. Linderman, Alana E. O'Mara, Kenneth Y. Zhu, Aaron M. Cypess
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Medicine, Research & Experimental
Evelien Schaafsma, Yanding Zhao, Yue Wang, Frederick S. Varn, Kenneth Zhu, Huan Yang, Chao Cheng
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Endocrinology & Metabolism
Cheryl Cero, Hannah J. Lea, Kenneth Y. Zhu, Aaron M. Cypess
Letter
Oncology
Emily Zhou, Baoyi Zhang, Kenneth Zhu, Evelien Schaafsma, Runjun D. Kumar, Chao Cheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, Research & Experimental
Cheryl Cero, Hannah J. Lea, Kenneth Y. Zhu, Farnaz Shamsi, Yu-Hua Tseng, Aaron M. Cypess
Summary: This study demonstrates the critical role of β(3)-AR in regulating lipolysis and thermogenesis in human brown/beige adipocytes. Silencing of β(3)-AR compromised multiple components of cellular machinery essential for thermogenesis and fatty acid metabolism. Selective human β(3)-AR agonists could potentially offer metabolic benefits in humans.
Article
Endocrinology & Metabolism
Zahraa Abdul Sater, Cheryl Cero, Anne E. Pierce, Hannah J. Lea, Houssein Abdul Sater, Kenneth Y. Zhu, Naili Liu, Yinyan Ma, Oksana Gavrilova, Aaron M. Cypess
Summary: The combination therapy of ALA and a beta 3-AR agonist showed significant improvements in body composition and inflammation levels in diet-induced obese mice. Mice receiving ALA+CL had significantly reduced body weight and body fat percentage, along with lower inflammation levels in adipose tissue compared to other groups. This suggests that targeting AT immune modulation could be a potential therapeutic strategy for obesity.