β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

(2020) Alana E. O’Mara et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

The metabolic effects of mirabegron are mediated primarily by β 3 ‐adrenoceptors

(2020) Nodi Dehvari et al.   Pharmacology Research & Perspectives

Brown and Brite: The Fat Soldiers in the Anti-obesity Fight

(2019) Shireesh Srivastava et al.   Frontiers in Physiology

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

(2019) Luiz Osório Leiria et al.   Cell Metabolism

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

(2019) Yuki Sakamoto et al.   DISEASE MARKERS

Beta-1 and not beta-3-adrenergic receptors may be the primary regulator of human brown adipocyte metabolism

(2019) Mette Ji Riis-Vestergaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides

(2018) Graeme Weir et al.   Cell Metabolism

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist

(2018) Alison S. Baskin et al.   DIABETES

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

(2018) Gemma Navarro et al.   Nature Communications

Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice

(2018) Jae Hoon Jeong et al.   Scientific Reports

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Brown adipose tissue detected by PET/CT imaging is associated with less central obesity

(2017) Aileen L. Green et al.   NUCLEAR MEDICINE COMMUNICATIONS

The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis

(2017) Cheryl Cero et al.   Molecular Metabolism

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

(2017) Rókus Kriszt et al.   Scientific Reports

Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats

(2016) Amy Warner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

The GPCR heterotetramer: challenging classical pharmacology

(2015) Sergi Ferré   TRENDS IN PHARMACOLOGICAL SCIENCES

Adipose Fatty Acid Oxidation Is Required for Thermogenesis and Potentiates Oxidative Stress-Induced Inflammation

(2015) Jieun Lee et al.   Cell Reports

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance

(2014) Mark J. W. Hanssen et al.   DIABETOLOGIA

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

(2014) Y. Li et al.   EMBO REPORTS

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

The new radioligand [3H]-L 748,337 differentially labels human and rat β3-adrenoceptors

(2013) Jan-Peter van Wieringen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes

(2013) Marica Bordicchia et al.   JOURNAL OF HYPERTENSION

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

(2013) Janne Orava et al.   Obesity

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

β1-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β3-adrenergic receptor-knockout mice via nonshivering thermogenesis

(2011) Charlotte L. Mattsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

(2011) Tomas B. Waldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptors

(2010) Jillian G Baker   BRITISH JOURNAL OF PHARMACOLOGY

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial long chain fatty acid β-oxidation in man and mouse

(2009) Malika Chegary et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Do gene polymorphisms alone or in combination affect the function of human β3-adrenoceptors?

(2009) Wim Vrydag et al.   BRITISH JOURNAL OF PHARMACOLOGY

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

(2009) Maria Cristina Zingaretti et al.   FASEB JOURNAL

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipolysis and lipid mobilization in human adipose tissue

(2009) Max Lafontan et al.   PROGRESS IN LIPID RESEARCH

Human Multipotent Adipose-Derived Stem Cells Differentiate into Functional Brown Adipocytes

(2009) Christian Elabd et al.   STEM CELLS

Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

(2008) Gordon S. Lynch et al.   PHYSIOLOGICAL REVIEWS