Multiple T6SSs, Mobile Auxiliary Modules, and Effectors Revealed in a Systematic Analysis of the Vibrio parahaemolyticus Pan-Genome

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

(2022) Hadar Cohen et al.   eLife

An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

(2021) Marcos H de Moraes et al.   eLife

Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens

(2021) Biswanath Jana et al.   EMBO REPORTS

Essential functions of chaperones and adaptors of protein secretion systems in Gram‐negative bacteria

(2021) Kevin Manera et al.   FEBS Journal

Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins

(2021) Juvenal Lopez et al.   JOURNAL OF BACTERIOLOGY

Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA

(2021) Dukas Jurėnas et al.   NUCLEIC ACIDS RESEARCH

Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells

(2021) Laura M. Nolan et al.   Nature Microbiology

A binary effector module secreted by a type VI secretion system

(2021) Yasmin Dar et al.   EMBO REPORTS

VgrG-dependent effectors and chaperones modulate the assembly of the type VI secretion system

(2021) Xiaoye Liang et al.   PLoS Pathogens

Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines

(2020) Timothy A. Klein et al.   TRENDS IN MICROBIOLOGY

A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors

(2020) Chaya M. Fridman et al.   Nature Communications

Envelope stress responses defend against type six secretion system attacks independently of immunity proteins

(2020) Steven J. Hersch et al.   Nature Microbiology

Polymorphic Toxins and Their Immunity Proteins: Diversity, Evolution, and Mechanisms of Delivery

(2020) Zachary C. Ruhe et al.   Annual Review of Microbiology

A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan

(2020) Stephanie Sibinelli-Sousa et al.   Cell Reports

Defending against the Type Six Secretion System: beyond Immunity Genes

(2020) Steven J. Hersch et al.   Cell Reports

Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species

(2019) Lisa C. Metzger et al.   ENVIRONMENTAL MICROBIOLOGY

Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae

(2019) Noémie Matthey et al.   eLife

Type VI secretion system: a modular toolkit for bacterial dominance

(2019) Biswanath Jana et al.   Future Microbiology

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

(2019) Shehryar Ahmad et al.   NATURE

A modular effector with a DNase domain and a marker for T6SS substrates

(2019) Biswanath Jana et al.   Nature Communications

A family of Type VI secretion system effector proteins that form ion-selective pores

(2019) Giuseppina Mariano et al.   Nature Communications

Eco-Evolutionary Dynamics Linked to Horizontal Gene Transfer in Vibrios

(2018) Frédérique Le Roux et al.   Annual Review of Microbiology

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

(2018) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Vibrio spp. infections

(2018) Craig Baker-Austin et al.   Nature Reviews Disease Primers

Conditional toxicity and synergy drive diversity among antibacterial effectors

(2018) Kaitlyn D. LaCourse et al.   Nature Microbiology

Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins

(2018) See-Yeun Ting et al.   CELL

The Antibacterial and Anti-Eukaryotic Type VI Secretion System MIX-Effector Repertoire in Vibrionaceae

(2018) Yasmin Dar et al.   Marine Drugs

The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors

(2018) Panayiota Pissaridou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system

(2017) Jenny Y. Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Proteins of Type VI Secretion System Effectors

(2017) Daniel Unterweger et al.   TRENDS IN MICROBIOLOGY

Horizontal Gene Transfer of Functional Type VI Killing Genes by Natural Transformation

(2017) Jacob Thomas et al.   mBio

The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems

(2017) Jiale Ma et al.   Virulence

The Role of Type VI Secretion System Effectors in Target Cell Lysis and Subsequent Horizontal Gene Transfer

(2017) Peter David Ringel et al.   Cell Reports

Type VI Secretion Effectors: Methodologies and Biology

(2017) Yun-Wei Lien et al.   Frontiers in Cellular and Infection Microbiology

Cryo-EM structure of the extended type VI secretion system sheath–tube complex

(2017) Jing Wang et al.   Nature Microbiology

OrthoANI: An improved algorithm and software for calculating average nucleotide identity

(2016) Imchang Lee et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures

(2016) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Identification of divergent type VI secretion effectors using a conserved chaperone domain

(2015) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer

(2015) S. Borgeaud et al.   SCIENCE

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

(2015) Dor Salomon et al.   PLoS Pathogens

Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

(2014) Lay-Sun Ma et al.   Cell Host & Microbe

The VgrG Proteins Are “à la Carte” Delivery Systems for Bacterial Type VI Effectors

(2014) Abderrahman Hachani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1

(2014) D. Salomon et al.   MICROBIOLOGY-SGM

Marker for type VI secretion system effectors

(2014) D. Salomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of the infectious nature of the agent of acute hepatopancreatic necrosis syndrome affecting penaeid shrimp

(2013) L Tran et al.   DISEASES OF AQUATIC ORGANISMS

Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

(2013) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competence and natural transformation in vibrios

(2013) Yan Sun et al.   MOLECULAR MICROBIOLOGY

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

(2013) Alistair B. Russell et al.   NATURE

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Vibrio parahaemolyticus Type VI Secretion System 1 Is Activated in Marine Conditions to Target Bacteria, and Is Differentially Regulated from System 2

(2013) Dor Salomon et al.   PLoS One

Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae

(2013) T. G. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Expression Profile of Type VI Secretion System Immunity Genes Protects Pandemic Vibrio cholerae

(2013) Sarah T. Miyata et al.   PLoS Pathogens

Putative type VI secretion systems of Vibrio parahaemolyticus contribute to adhesion to cultured cell monolayers

(2012) Ying Yu et al.   ARCHIVES OF MICROBIOLOGY

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

(2012) Dapeng Zhang et al.   Biology Direct

A Widespread Bacterial Type VI Secretion Effector Superfamily Identified Using a Heuristic Approach

(2012) Alistair B. Russell et al.   Cell Host & Microbe

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

A widespread family of polymorphic contact-dependent toxin delivery systems in bacteria

(2010) Stephanie K. Aoki et al.   NATURE

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?

(2009) Frédéric Boyer et al.   BMC GENOMICS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Type VI secretion: a beginner's guide

(2008) Lewis EH Bingle et al.   CURRENT OPINION IN MICROBIOLOGY