Essential functions of chaperones and adaptors of protein secretion systems in Gram‐negative bacteria

The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in Acinetobacter baumannii

(2020) Juvenal Lopez et al.   mBio

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Envelope stress responses defend against type six secretion system attacks independently of immunity proteins

(2020) Steven J. Hersch et al.   Nature Microbiology

Structural basis for loading and inhibition of a bacterial T6 SS phospholipase effector by the VgrG spike

(2020) Nicolas Flaugnatti et al.   EMBO JOURNAL

Type VI secretion system effector proteins: Effective weapons for bacterial competitiveness

(2020) Ruth E. Hernandez et al.   CELLULAR MICROBIOLOGY

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

(2020) Amit Meir et al.   Nature Communications

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

(2020) Shehryar Ahmad et al.   eLife

Delivery of the Pseudomonas aeruginosa Phospholipase Effectors PldA and PldB in a VgrG- and H2-T6SS-Dependent Manner

(2019) Sarah Wettstadt et al.   Frontiers in Microbiology

A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in Pseudomonas aeruginosa

(2019) Benjamin Berni et al.   Frontiers in Microbiology

Diverse roles of TssA‐like proteins in the assembly of bacterial type VI secretion systems

(2019) Johannes Paul Schneider et al.   EMBO JOURNAL

Control of Type III Secretion System Effector/Chaperone Ratio Fosters Pathogen Adaptation to Host-Adherent Lifestyle

(2019) Netanel Elbaz et al.   mBio

An onboard checking mechanism ensures effector delivery of the type VI secretion system in Vibrio cholerae

(2019) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV secretion in Gram-negative and Gram-positive bacteria

(2018) Elisabeth Grohmann et al.   MOLECULAR MICROBIOLOGY

Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

(2018) Amit Meir et al.   Nature Communications

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

(2018) Fei Ye et al.   Nature Communications

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

(2018) Brianne J. Burkinshaw et al.   Nature Microbiology

Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems

(2018) Lea Krampen et al.   Nature Communications

Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli

(2018) Dustin J. Little et al.   PLoS Pathogens

Mechanism of loading and translocation of type VI secretion system effector Tse6

(2018) Dennis Quentin et al.   Nature Microbiology

Structure of the type VI secretion system TssK–TssF–TssG baseplate subcomplex revealed by cryo-electron microscopy

(2018) Young-Jun Park et al.   Nature Communications

Biogenesis and structure of a type VI secretion baseplate

(2018) Yassine Cherrak et al.   Nature Microbiology

PAAR-Rhs proteins harbor various C-terminal toxins to diversify the antibacterial pathways of type VI secretion systems

(2017) Jiale Ma et al.   ENVIRONMENTAL MICROBIOLOGY

Assembly, structure, function and regulation of type III secretion systems

(2017) Wanyin Deng et al.   NATURE REVIEWS MICROBIOLOGY

Structural insights into the roles of the IcmS–IcmW complex in the type IVb secretion system ofLegionella pneumophila

(2017) Jianpo Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host cell attachment elicits posttranscriptional regulation in infecting enteropathogenic bacteria

(2017) Naama Katsowich et al.   SCIENCE

Adaptor Proteins of Type VI Secretion System Effectors

(2017) Daniel Unterweger et al.   TRENDS IN MICROBIOLOGY

The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems

(2017) Jiale Ma et al.   Virulence

Cryo-EM structure of the extended type VI secretion system sheath–tube complex

(2017) Jing Wang et al.   Nature Microbiology

Architecture of the type IV coupling protein complex of Legionella pneumophila

(2017) Mi-Jeong Kwak et al.   Nature Microbiology

CagA-mediated pathogenesis of Helicobacter pylori

(2016) Abolghasem Tohidpour   MICROBIAL PATHOGENESIS

A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery

(2016) Nicolas Flaugnatti et al.   MOLECULAR MICROBIOLOGY

VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor–effector complex

(2016) Devanand D. Bondage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III Secretion: Building and Operating a Remarkable Nanomachine

(2016) Athina G. Portaliou et al.   TRENDS IN BIOCHEMICAL SCIENCES

VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

(2016) Francesca R. Cianfanelli et al.   PLoS Pathogens

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

Structure of the Type VI Secretion System Contractile Sheath

(2015) Mikhail Kudryashev et al.   CELL

Chimeric adaptor proteins translocate diverse type VI secretion system effectors in Vibrio cholerae

(2015) D. Unterweger et al.   EMBO JOURNAL

Intraspecies Competition in Serratia marcescens Is Mediated by Type VI-Secreted Rhs Effectors and a Conserved Effector-Associated Accessory Protein

(2015) Juliana Alcoforado Diniz et al.   JOURNAL OF BACTERIOLOGY

Biogenesis and structure of a type VI secretion membrane core complex

(2015) Eric Durand et al.   NATURE

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

Identification of divergent type VI secretion effectors using a conserved chaperone domain

(2015) Xiaoye Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of AcrH–AopB Chaperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly

(2015) Van Sang Nguyen et al.   STRUCTURE

Assembly and structure of the T3SS

(2014) Brianne J. Burkinshaw et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta

(2014) Lay-Sun Ma et al.   Cell Host & Microbe

Genetically distinct pathways guide effector export through the type VI secretion system

(2014) John C. Whitney et al.   MOLECULAR MICROBIOLOGY

Marker for type VI secretion system effectors

(2014) D. Salomon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A View to a Kill: The Bacterial Type VI Secretion System

(2013) Brian T. Ho et al.   Cell Host & Microbe

Structure and properties of the C-terminal β-helical domain of VgrG protein from Escherichia coli O157

(2013) Kazuya Uchida et al.   JOURNAL OF BIOCHEMISTRY

Characterization of the Translocation-competent Complex between theHelicobacter pyloriOncogenic Protein CagA and the Accessory Protein CagF

(2013) Daniel A. Bonsor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemolysin Coregulated Protein Is an Exported Receptor and Chaperone of Type VI Secretion Substrates

(2013) Julie M. Silverman et al.   MOLECULAR CELL

ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion

(2013) Nicole Kapitein et al.   MOLECULAR MICROBIOLOGY

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

(2013) Mikhail M. Shneider et al.   NATURE

Rhs proteins from diverse bacteria mediate intercellular competition

(2013) S. Koskiniemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells

(2013) Christopher J. Alteri et al.   PLoS Pathogens

Expanded Roles for Multicargo and Class 1B Effector Chaperones in Type III Secretion

(2012) N. A. Thomas et al.   JOURNAL OF BACTERIOLOGY

Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system

(2012) Carr D. Vincent et al.   MOLECULAR MICROBIOLOGY

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

Type 6 Secretion Dynamics Within and Between Bacterial Cells

(2012) M. Basler et al.   SCIENCE

The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates

(2012) Molly C. Sutherland et al.   PLoS Pathogens

Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system

(2011) Julie E. Button et al.   MOLECULAR MICROBIOLOGY

A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems

(2011) M. Lara-Tejero et al.   SCIENCE

Biogenesis, Regulation, and Targeting of the Type III Secretion System

(2011) Thierry Izoré et al.   STRUCTURE

A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria

(2010) Rachel D. Hood et al.   Cell Host & Microbe

Comparative genomic analysis uncovers 3 novel loci encoding type six secretion systems differentially distributed in Salmonella serotypes

(2009) Carlos J Blondel et al.   BMC GENOMICS

Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of Legionella pneumophila

(2009) F. Habyarimana et al.   INFECTION AND IMMUNITY

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin

(2009) P. G. Leiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of gene expression by type III secretory activity

(2008) Evan D Brutinel et al.   CURRENT OPINION IN MICROBIOLOGY

Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners

(2008) O. Dym et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA