Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions

Ena/VASP proteins in cell edge protrusion, migration and adhesion

(2022) Jan Faix et al.   JOURNAL OF CELL SCIENCE

Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation

(2021) Ulrich Dobramysl et al.   JOURNAL OF CELL BIOLOGY

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Colocalization Colormap –an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals

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Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

(2020) Julia Damiano-Guercio et al.   eLife

Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin

(2020) Karen W. Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Array programming with NumPy

(2020) Charles R. Harris et al.   NATURE

Lipid-Composition-Mediated Forces Can Stabilize Tubular Assemblies of I-BAR Proteins

(2020) Zack Jarin et al.   BIOPHYSICAL JOURNAL

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

(2019) Guillaume Jacquemet et al.   CURRENT BIOLOGY

Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia crosslinker fascin

(2019) Alyssa J. Harker et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanism of IRSp53 inhibition by 14-3-3

(2019) David J. Kast et al.   Nature Communications

Actin dynamics drive cell-like membrane deformation

(2019) Camille Simon et al.   Nature Physics

IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration

(2019) David J. Kast et al.   MOLECULAR BIOLOGY OF THE CELL

Unusual Organization of I-BAR Proteins on Tubular and Vesicular Membranes

(2019) Zack Jarin et al.   BIOPHYSICAL JOURNAL

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(2019) Daniel A. Pollard et al.   MOLECULAR BIOLOGY OF THE CELL

Guided by curvature: shaping cells by coupling curved membrane proteins and cytoskeletal forces

(2018) N. S. Gov   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

(2018) Feng-Ching Tsai et al.   eLife

Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly

(2018) Lorna E. Young et al.   JOURNAL OF CELL SCIENCE

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

(2018) S. de Beco et al.   Nature Communications

Assembling actin filaments for protrusion

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Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis

(2018) Yosuke Senju et al.   CURRENT OPINION IN CELL BIOLOGY

Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays

(2017) Stefan Brühmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides

(2017) Yosuke Senju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell type–dependent mechanisms for formin-mediated assembly of filopodia

(2015) Lorna E. Young et al.   MOLECULAR BIOLOGY OF THE CELL

IRSp53 senses negative membrane curvature and phase separates along membrane tubules

(2015) Coline Prévost et al.   Nature Communications

Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

(2015) Scott D Hansen et al.   eLife

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function

(2014) Melanie Barzik et al.   MOLECULAR BIOLOGY OF THE CELL

Reconstituting actomyosin-dependent mechanosensitive protein complexes in vitro

(2014) Corina Ciobanasu et al.   Nature Protocols

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

(2014) David J Kast et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic Shaping of Cellular Membranes by Phospholipids and Membrane-Deforming Proteins

(2014) Shiro Suetsugu et al.   PHYSIOLOGICAL REVIEWS

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Helical buckling of actin inside filopodia generates traction

(2014) Natascha Leijnse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin

(2014) Laura Picas et al.   Nature Communications

Gel-Assisted Formation of Giant Unilamellar Vesicles

(2013) Andreas Weinberger et al.   BIOPHYSICAL JOURNAL

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

(2013) Andrea Disanza et al.   EMBO JOURNAL

Islands of Conformational Stability for Filopodia

(2013) D. Robert Daniels et al.   PLoS One

Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip

(2013) T. Bornschlogl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-Sculpting BAR Domains Generate Stable Lipid Microdomains

(2013) Hongxia Zhao et al.   Cell Reports

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(2012) Johannes Schindelin et al.   NATURE METHODS

mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

(2011) Wah Ing Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Actin Filament Bundling by Fascin

(2011) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filopodia initiation

(2011) Changsong Yang et al.   Cell Adhesion & Migration

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

(2010) Scott D. Hansen et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins

(2009) Juha Saarikangas et al.   CURRENT BIOLOGY

Filopodia: Complex models for simple rods

(2009) Jan Faix et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

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Coordination of Membrane and Actin Cytoskeleton Dynamics during Filopodia Protrusion

(2009) Changsong Yang et al.   PLoS One

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

(2008) Dennis Breitsprecher et al.   EMBO JOURNAL

The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics

(2008) Kim Buay Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-induced bundling of actin filaments

(2008) Allen P. Liu et al.   Nature Physics

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY