Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions

(2019) Julieann I. Puleo et al.   JOURNAL OF CELL BIOLOGY

Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units

(2018) Lorna E. Young et al.   CURRENT BIOLOGY

The Arp2/3 Regulatory System and Its Deregulation in Cancer

(2018) Nicolas Molinie et al.   PHYSIOLOGICAL REVIEWS

Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

(2018) Michael Schnoor et al.   TRENDS IN CELL BIOLOGY

Micromanipulation Techniques Allowing Analysis of Morphogenetic Dynamics and Turnover of Cytoskeletal Regulators

(2018) Georgi Dimchev et al.   Jove-Journal of Visualized Experiments

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

(2018) Matthias Schaks et al.   CURRENT BIOLOGY

Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly

(2018) Lorna E. Young et al.   JOURNAL OF CELL SCIENCE

Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes

(2017) Christof Litschko et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Actin assembly mechanisms at a glance

(2017) Klemens Rottner et al.   JOURNAL OF CELL SCIENCE

Efficiency of lamellipodia protrusion is determined by the extent of cytosolic actin assembly

(2017) Georgi Dimchev et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct VASP tetramers synergize in the processive elongation of individual actin filaments from clustered arrays

(2017) Stefan Brühmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FMNL formins boost lamellipodial force generation

(2017) Frieda Kage et al.   Nature Communications

Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility

(2016) Julien Pernier et al.   DEVELOPMENTAL CELL

Cell type–dependent mechanisms for formin-mediated assembly of filopodia

(2015) Lorna E. Young et al.   MOLECULAR BIOLOGY OF THE CELL

A resilient formin-derived cortical actin meshwork in the rear drives actomyosin-based motility in 2D confinement

(2015) Nagendran Ramalingam et al.   Nature Communications

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

(2015) Sari Tojkander et al.   eLife

Palladin promotes assembly of non-contractile dorsal stress fibers through VASP recruitment

(2014) G. Gateva et al.   JOURNAL OF CELL SCIENCE

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

(2013) A. Steffen et al.   JOURNAL OF CELL SCIENCE

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin

(2013) Stefan A. Koestler et al.   MOLECULAR BIOLOGY OF THE CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42

(2012) Jennifer Block et al.   CURRENT BIOLOGY

Mena binds α5 integrin directly and modulates α5β1 function

(2012) Stephanie L. Gupton et al.   JOURNAL OF CELL BIOLOGY

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

(2012) Praveen Suraneni et al.   JOURNAL OF CELL BIOLOGY

Actin branching in the initiation and maintenance of lamellipodia

(2012) M. Vinzenz et al.   JOURNAL OF CELL SCIENCE

Direct Determination of Actin Polarity in the Cell

(2012) Akihiro Narita et al.   JOURNAL OF MOLECULAR BIOLOGY

Actin filament tracking in electron tomograms of negatively stained lamellipodia using the localized radon transform

(2012) Christoph Winkler et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cells Assemble Invadopodia-Like Structures and Invade into Matrigel in a Matrix Metalloprotease Dependent Manner in the Circular Invasion Assay

(2012) Xinzi Yu et al.   PLoS One

Molecular mechanism of Ena/VASP-mediated actin-filament elongation

(2011) Dennis Breitsprecher et al.   EMBO JOURNAL

Cofilin cooperates with fascin to disassemble filopodial actin filaments

(2011) D. Breitsprecher et al.   JOURNAL OF CELL SCIENCE

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

(2011) Renaud Poincloux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal Adhesion Assembly in Myofibroblasts Fosters a Microenvironment that Promotes Tumor Growth

(2010) Ningling Kang et al.   AMERICAN JOURNAL OF PATHOLOGY

Assembly of filopodia by the formin FRL2 (FMNL3)

(2010) Elizabeth S. Harris et al.   Cytoskeleton

Ena drives invasive macrophage migration in Drosophila embryos

(2010) P. K. Tucker et al.   Disease Models & Mechanisms

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

(2010) Scott D. Hansen et al.   JOURNAL OF CELL BIOLOGY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Electron tomography reveals unbranched networks of actin filaments in lamellipodia

(2010) Edit Urban et al.   NATURE CELL BIOLOGY

The role of formins in filopodia formation

(2009) Harry Mellor   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Filopodia: Complex models for simple rods

(2009) Jan Faix et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ena/VASP: towards resolving a pointed controversy at the barbed end

(2009) J. E. Bear et al.   JOURNAL OF CELL SCIENCE

Cortactin Promotes Migration and Platelet-derived Growth Factor-induced Actin Reorganization by Signaling to Rho-GTPases

(2009) Frank P.L. Lai et al.   MOLECULAR BIOLOGY OF THE CELL

The WAVE regulatory complex is inhibited

(2009) Ayman M Ismail et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Capping Protein Increases the Rate of Actin-Based Motility by Promoting Filament Nucleation by the Arp2/3 Complex

(2008) Orkun Akin et al.   CELL

A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis

(2008) Ulrike Philippar et al.   DEVELOPMENTAL CELL

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

(2008) Dennis Breitsprecher et al.   EMBO JOURNAL

Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella

(2008) Maria Nemethova et al.   JOURNAL OF CELL BIOLOGY

Filopodia formation induced by active mDia2/Drf3

(2008) J. BLOCK et al.   JOURNAL OF MICROSCOPY

Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front

(2008) Stefan A. Koestler et al.   NATURE CELL BIOLOGY

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Mechano-Coupling and Regulation of Contractility by the Vinculin Tail Domain

(2007) Claudia Tanja Mierke et al.   BIOPHYSICAL JOURNAL