Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutant colorectal cancer

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential

(2021) Guang Lei et al.   BIOESSAYS

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

(2021) Zhaohui Pei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

CISD3 inhibition drives cystine-deprivation induced ferroptosis

(2021) Yanchun Li et al.   Cell Death & Disease

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

(2021) Ruize Gao et al.   EMBO Molecular Medicine

Cetuximab promotes RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS mutant colorectal cancer

(2021) Jiawen Yang et al.   Cell Death & Disease

Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer

(2021) Chuncao Xu et al.   Cell Death Discovery

Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter

(2020) Wei Jiang et al.   Aging-US

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

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Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

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A potential role for aspirin in the prevention and treatment of cholangiocarcinoma

(2020) Xizi Shen et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

(2020) Jaewang Lee et al.   Redox Biology

Cetuximab plus irinotecan administered biweekly with reduced infusion time to heavily pretreated patients with metastatic colorectal cancer and related RAS and BRAF mutation status

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Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

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Targeting PI3K in cancer: mechanisms and advances in clinical trials

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Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

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Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Strategies for Colorectal Cancer Screening

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Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

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Recent Progress in Ferroptosis Inducers for Cancer Therapy

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Colorectal cancer

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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1α axis regulates ER stress during high-carbohydrate feeding

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Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

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Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

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Complex roles of the old drug aspirin in cancer chemoprevention and therapy

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Metabolic features of cancer stem cells: the emerging role of lipid metabolism

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Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

(2018) Ali Talebi et al.   Nature Communications

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

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SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

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mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

(2017) Walaa Eid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling

(2016) Whitney S. Henry et al.   CANCER RESEARCH

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

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Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances

(2016) Gustaw Lech   WORLD JOURNAL OF GASTROENTEROLOGY

Colorectal cancer screening: a global overview of existing programmes

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Aspirin Promotes Oligodendroglial Differentiation Through Inhibition of Wnt Signaling Pathway

(2015) Nanxin Huang et al.   MOLECULAR NEUROBIOLOGY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Ferroptotic Cancer Cell Death by GPX4

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Molecular Pathways: Aspirin and Wnt Signaling--A Molecularly Targeted Approach to Cancer Prevention and Treatment

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival

(2012) Xiaoyun Liao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Panitumumab in Patients with KRAS Wild-Type Colorectal Cancer after Progression on Cetuximab

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COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

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Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

(2010) Peter M Rothwell et al.   LANCET

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

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Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer

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