Dexmedetomidine Alleviates Neuropathic Pain via the TRPC6-p38 MAPK Pathway in the Dorsal Root Ganglia of Rats

ProBDNF induces sustained elevation of intracellular Ca 2+ possibly mediated by TRPM7 channels in rodent microglial cells

(2021) Yoshito Mizoguchi et al.   GLIA

The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain

(2021) Bei Miao et al.   LIFE SCIENCES

Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway

(2021) Meiyun Cai et al.   NEUROCHEMISTRY INTERNATIONAL

TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway

(2020) Qingzi Chen et al.   Cell Death & Disease

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model

(2020) Yongda Liu et al.   Frontiers in Neuroscience

The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury

(2020) Jing Wang et al.   Journal of Neuroinflammation

Mechanisms of Dexmedetomidine in Neuropathic Pain

(2020) Yang Zhao et al.   Frontiers in Neuroscience

Dexmedetomidine Alleviates CCI-Induced Neuropathic Pain via Inhibiting HMGB1-Mediated Astrocyte Activation and the TLR4/NF-κB Signaling Pathway in Rats

(2020) Erxian Zhao et al.   NEUROTOXICITY RESEARCH

K+ Channels in Primary Afferents and Their Role in Nerve Injury-Induced Pain

(2020) Peter A. Smith   Frontiers in Cellular Neuroscience

Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain

(2020) Xiaqing Ma et al.   Cell Death & Disease

Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats

(2019) José Eduardo Roa-Coria et al.   BMC NEUROSCIENCE

Dexmedetomidine modulates transient receptor potential vanilloid subtype 1

(2019) Byeong-Min Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathways in bronchial epithelial cells

(2018) Li-Fen Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat

(2018) Carmen De Caro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration

(2018) Nopporn Thangthaeng et al.   NUTRITION RESEARCH

General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation

(2018) Mun Yam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cannabidiol modulates serotonergic transmission and prevents allodynia and anxiety-like behavior in a model of neuropathic pain

(2018) Danilo De Gregorio et al.   PAIN

Dexmedetomidine Attenuates Neuropathic Pain by Inhibiting P2X7R Expression and ERK Phosphorylation in Rats

(2018) Jia-Piao Lin et al.   Experimental Neurobiology

Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels

(2018) Gábor Pozsgai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Spinal TRPC6 channels contributes to morphine-induced antinociceptive tolerance and hyperalgesia in rats

(2017) Hua Jin et al.   NEUROSCIENCE LETTERS

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

(2017) Giannina Descalzi et al.   Science Signaling

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

(2017) Giannina Descalzi et al.   Science Signaling

Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush

(2016) Wenjie Tang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes

(2016) Ji-Hee Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

α2 Adrenoceptor: a Target for Neuropathic Pain Treatment

(2016) Lorenzo Mannelli et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Store-Operated Ca2+ Entry (SOCE) and Purinergic Receptor-Mediated Ca2+ Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation

(2016) Daniel F. Gilbert et al.   Frontiers in Molecular Neuroscience

TRP channels: potential drug target for neuropathic pain

(2016) Lovish Marwaha et al.   INFLAMMOPHARMACOLOGY

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

(2016) Hatice Akpınar et al.   Scientific Reports

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety

(2015) Guo-Qiang Wang et al.   Nature Communications

p38 MAPK: A Potential Target of Chronic Pain

(2014) X. Lin et al.   CURRENT MEDICINAL CHEMISTRY

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats

(2012) Doo C. Choi et al.   EXPERIMENTAL NEUROLOGY

Activation ofKCNN3/SK3/KCa2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia

(2012) Amalia M. Dolga et al.   GLIA

Protective Roles for Potassium SK/KCa2 Channels in Microglia and Neurons

(2012) Amalia M. Dolga et al.   Frontiers in Pharmacology

Balancing Calcium Signals through TRPC5 and TRPC6 in Podocytes

(2011) A. Greka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Animal models of neuropathic pain

(2010) Amteshwar Singh Jaggi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

(2009) Volodymyr V. Tsvilovskyy et al.   GASTROENTEROLOGY

TRPC1 and TRPC6 Channels Cooperate with TRPV4 to Mediate Mechanical Hyperalgesia and Nociceptor Sensitization

(2009) N. Alessandri-Haber et al.   JOURNAL OF NEUROSCIENCE