TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathways in bronchial epithelial cells

Chronic inflammatory airway diseases: the central role of the epithelium revisited

(2016) S. T. Gohy et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response

(2015) Evan W. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

(2015) Wei Gao et al.   RESPIROLOGY

TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells

(2014) Jun Ichikawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients

(2014) Heounjeong Go et al.   RESPIRATORY MEDICINE

Transient Receptor Potential Channels and Regulation of Lung Endothelial Permeability

(2014) Patricia C. Villalta et al.   Pulmonary Circulation

High glucose-induced apoptosis in cultured podocytes involves TRPC6-dependent calcium entry via the RhoA/ROCK pathway

(2013) He Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MAPK/NF-κB-dependent upregulation of kinin receptors mediates airway hyperreactivity: A new perspective for the treatment

(2013) Yaping Zhang et al.   PHARMACOLOGICAL RESEARCH

Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs

(2012) Kate Gaffey et al.   EUROPEAN RESPIRATORY JOURNAL

TRP channels as therapeutic targets in airway disorders: a patent review

(2012) Delia Preti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Involvement of Phosphoinositide 3-Kinase and PTEN Protein in Mechanism of Activation of TRPC6 Protein in Vascular Smooth Muscle Cells

(2012) Michaël Monet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

(2012) Mohammad Tauseef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Balancing pro- and anti-inflammatory TLR4 signaling

(2012) Sabine Siegemund et al.   NATURE IMMUNOLOGY

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

Steroid-Insensitive ERK1/2 Activity Drives CXCL8 Synthesis and Neutrophilia by Airway Smooth Muscle

(2011) Stephanie Robins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes

(2011) Shan Chen et al.   CELL CALCIUM

Epithelial cells and airway diseases

(2011) David Proud et al.   IMMUNOLOGICAL REVIEWS

cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway

(2011) Bing Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRP channels: Emerging targets for respiratory disease

(2011) Katharine Helen Banner et al.   PHARMACOLOGY & THERAPEUTICS

A New Role for PTEN in Regulating Transient Receptor Potential Canonical Channel 6-mediated Ca2+Entry, Endothelial Permeability, and Angiogenesis

(2010) Vidisha Kini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarized Secretion of Interleukin (IL)-6 and IL-8 by Human Airway Epithelia 16HBE14o- Cells in Response to Cationic Polypeptide Challenge

(2010) Alison Wai-ming Chow et al.   PLoS One

TLR-4–Mediated Innate Immunity Is Reduced in Cystic Fibrosis Airway Cells

(2009) Gerrit John et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Expression of Transient Receptor Potential C6 Channels in Human Lung Macrophages

(2009) Tricia K. Finney-Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations

(2009) Lutz Birnbaumer   Annual Review of Pharmacology and Toxicology

On the putative role of transient receptor potential cation channels in asthma

(2009) B. Colsoul et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

Triterpenes Promote Keratinocyte Differentiation In Vitro, Ex Vivo and In Vivo: A Role for the Transient Receptor Potential Canonical (subtype) 6

(2009) Ute Woelfle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators--Identification of a Novel Pharmacophore

(2009) K. Leuner et al.   MOLECULAR PHARMACOLOGY

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils

(2008) N. Damann et al.   Acta Physiologica

Loss of classical transient receptor potential 6 channel reduces allergic airway response

(2008) S. Sel et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways

(2008) Weimin Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY