TRP channels: potential drug target for neuropathic pain

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

(2015) Mark D. Andrews et al.   ACS Medicinal Chemistry Letters

TRPV1: A Potential Drug Target for Treating Various Diseases

(2014) Rafael Brito et al.   Cells

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion

(2013) Tomomi Hara et al.   PAIN

Capsaicin for Neuropathic Pain: Linking Traditional Medicine and Molecular Biology

(2012) Maija Haanpää et al.   EUROPEAN NEUROLOGY

Aberrant TRPV1 Expression in Heat Hyperalgesia Associated with Trigeminal Neuropathic Pain

(2012) Hiroko Urano et al.   International Journal of Medical Sciences

Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin is Caused by the Enhanced Responsiveness of TRPA1 in Mice

(2012) Meng Zhao et al.   Molecular Pain

Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain

(2011) Lin Su et al.   BMC NEUROSCIENCE

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors

(2011) Juliette Descoeur et al.   EMBO Molecular Medicine

Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine

(2011) Daniel P. Poole et al.   GASTROENTEROLOGY

Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy

(2011) Diana Spicarova et al.   Journal of Neuroinflammation

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions

(2010) Louis S. Premkumar   AAPS Journal

High Glucose-Induced Oxidative Stress Increases Transient Receptor Potential Channel Expression in Human Monocytes

(2010) T. Wuensch et al.   DIABETES

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect

(2010) T. Watabiki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study

(2010) José R. Romero et al.   Translational Research

Abnormal calcium homeostasis in peripheral neuropathies

(2009) Paul Fernyhough et al.   CELL CALCIUM

Involvement of the transient receptor potential vanilloid 1 (TRPV1) in the development of acute visceral hyperalgesia during colorectal distension in rats

(2009) Anna Ravnefjord et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mecamylamine – a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders

(2009) Ingrid Bacher et al.   EXPERT OPINION ON PHARMACOTHERAPY

Spinal Nerve Ligation in Mouse Upregulates TRPV1 Heat Function in Injured IB4-Positive Nociceptors

(2009) Daniel Vilceanu et al.   JOURNAL OF PAIN

Mitochondrial malfunction and Ca2+ dyshomeostasis drive neuronal pathology in diabetes

(2008) A VERKHRATSKY et al.   CELL CALCIUM

TRPV1: A Target for Next Generation Analgesics

(2008) Louis Premkumar et al.   Current Neuropharmacology

Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections

(2008) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE

Intact Aδ-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats

(2008) G. Ji et al.   NEUROSCIENCE

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

(2005) Shang-Zhong Xu et al.   BRITISH JOURNAL OF PHARMACOLOGY