Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer

CSF1/CSF1R signaling mediates malignant pleural effusion formation

(2022) Chrysavgi N. Kosti et al.   JCI Insight

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phase I/Ib clinical trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination With Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors

(2021) Giuseppe Curigliano et al.   CLINICAL CANCER RESEARCH

A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications

(2021) Sahar Sadat Sedighzadeh et al.   Translational Lung Cancer Research

Lactic acid in macrophage polarization: The significant role in inflammation and cancer

(2021) Hai-cun Zhou et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Tumor Microenvironment-Derived Metabolites: A Guide to Find New Metabolic Therapeutic Targets and Biomarkers

(2021) Juan C. García-Cañaveras et al.   Cancers

Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma

(2021) Kuang Du et al.   Nature Communications

The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers

(2020) Nina Kozlova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes

(2020) Floris Dammeijer et al.   CANCER CELL

Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.

(2019) Ila J Datar et al.   CLINICAL CANCER RESEARCH

Targeting Tumors with IL-10 Prevents Dendritic Cell-Mediated CD8+ T Cell Apoptosis

(2019) Jian Qiao et al.   CANCER CELL

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

(2018) Alan Bénard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction

(2018) Rui Feng et al.   Cell Communication and Signaling

Robust prediction of response to immune checkpoint blockade therapy in metastatic melanoma

(2018) Noam Auslander et al.   NATURE MEDICINE

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

The cell-cell interaction between tumor-associated macrophages and small cell lung cancer cells is involved in tumor progression via STAT3 activation

(2017) Toyohisa Iriki et al.   LUNG CANCER

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

Non–Small Cell Lung Cancer, Version 2.2013

(2017) David S. Ettinger et al.   Journal of the National Comprehensive Cancer Network

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

Diverse macrophages polarization in tumor microenvironment

(2016) Inmoo Rhee   ARCHIVES OF PHARMACAL RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199)

(2016) V M Patel et al.   LEUKEMIA

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

(2016) Rikke B. Holmgaard et al.   EBioMedicine

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages

(2015) Xingwei Jiang et al.   CLINICAL IMMUNOLOGY

Tim-3 expression in tumour-associated macrophages: a new player in HCC progression

(2015) Tobias Flecken et al.   GUT

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

(2015) Wenjiang Yan et al.   GUT

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

The Coordinated Actions of TIM-3 on Cancer and Myeloid Cells in the Regulation of Tumorigenicity and Clinical Prognosis in Clear Cell Renal Cell Carcinomas

(2015) Y. Komohara et al.   Cancer Immunology Research

CD14+macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

(2015) A Marijne Heeren et al.   OncoImmunology

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression

(2015) Ang Yuan et al.   Scientific Reports

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

The monocyte-macrophage axis in the intestine

(2014) Calum C. Bain et al.   CELLULAR IMMUNOLOGY

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

(2014) Yanping Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF -1

(2014) N. D. L. Savage et al.   JOURNAL OF IMMUNOLOGY

Immune Complex/Ig Negatively Regulate TLR4-Triggered Inflammatory Response in Macrophages through Fc RIIb-Dependent PGE2 Production

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment

(2014) Lunxu Liu et al.   Drug Design Development and Therapy

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

(2013) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tumor-Infiltrating Immune Cells: Triggers for Tumor Capsule Disruption and Tumor Progression?

(2013) Bin Jiang et al.   International Journal of Medical Sciences

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response

(2013) X. Yang et al.   JOURNAL OF IMMUNOLOGY

Discrete functions of M 2a and M 2c macrophage subsets determine their relative efficacy in treating chronic kidney disease

(2013) Junyu Lu et al.   KIDNEY INTERNATIONAL

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Mucosal CXCR4+IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation

(2012) Michihide Uo et al.   GUT

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

(2012) Kenneth J. Pienta et al.   INVESTIGATIONAL NEW DRUGS

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

(2011) Michel DuPage et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes

(2011) Ying Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Leukocyte composition of human breast cancer

(2011) B. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

Phenotypic and functional switch of macrophages induced by regulatory CD4+ CD25+ T cells in mice

(2010) Guangwei Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Tim3 binding to galectin-9 stimulates antimicrobial immunity

(2010) Pushpa Jayaraman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

(2010) Elias A Said et al.   NATURE MEDICINE

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

(2009) J. Van den Bossche et al.   BLOOD

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Never Underestimate the Power of a Neutrophil

(2009) Marco A. Cassatella et al.   IMMUNITY

Regulation of Inflammatory Monocyte/Macrophage Recruitment from the Bone Marrow during Murine Cytomegalovirus Infection: Role for Type I Interferons in Localized Induction of CCR2 Ligands

(2009) M. J. Crane et al.   JOURNAL OF IMMUNOLOGY

Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors

(2009) L. S. Ojalvo et al.   JOURNAL OF IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Rα, IL-13Rα1, and γc regulates relative cytokine sensitivity

(2008) Ilkka S. Junttila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY