Upregulation of BCL-2 by acridone derivative through gene promoter i-motif for alleviating liver damage of NAFLD/NASH

Bouchardatine analogue alleviates NAFLD/NASH in high fat fed mice via blunting ATP synthase activity

(2019) Yong Rao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis

(2019) Dechen Liu et al.   Cell Death & Disease

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation

(2018) Bing Shu et al.   CHEMICAL COMMUNICATIONS

I-motif DNA structures are formed in the nuclei of human cells

(2018) Mahdi Zeraati et al.   Nature Chemistry

i-Motif DNA: structural features and significance to cell biology

(2018) Hala Abou Assi et al.   NUCLEIC ACIDS RESEARCH

OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis

(2018) Guangyong Sun et al.   Cell Reports

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Fighting the fatty liver

(2017) Liam Drew   NATURE

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH

(2017) Elisé P. Wright et al.   NUCLEIC ACIDS RESEARCH

Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay

(2017) Qiran Sheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis

(2016) Ruonan Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update

(2015) Waseem Ahmad Siddiqui et al.   ARCHIVES OF TOXICOLOGY

Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs

(2015) Miguel Garavís et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

(2014) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL Is a Molecular Switch for Control of Gene Expression That Can Be Modulated by Small Molecules

(2014) Hyun-Jin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apoptotic and anti-apoptotic seromarkers for assessment of disease severity of non-alcoholic steatohepatitis

(2014) Hanan El Bassat et al.   Arab Journal of Gastroenterology

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency

(2013) Kan Toriguchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

High-fat-cholesterol diet mainly induced necrosis in fibrotic steatohepatitis rat by suppressing caspase activity

(2013) Husna Yetti et al.   LIFE SCIENCES

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

(2012) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

Insights into the biomedical effects of carboxylated single-wall carbon nanotubes on telomerase and telomeres

(2012) Yong Chen et al.   Nature Communications

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

(2010) Arivazhagan Rajendran et al.   CHEMICAL COMMUNICATIONS

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C

(2010) Carmelo García-Monzón et al.   JOURNAL OF HEPATOLOGY