Structure-based neutralizing mechanisms for SARS-CoV-2 antibodies

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

(2022) Alison Tarke et al.   CELL

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

(2022) Wanwisa Dejnirattisai et al.   CELL

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

(2022) Sandile Cele et al.   NATURE

Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants

(2022) Kang Wang et al.   NATURE

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

(2022) Yunlong Cao et al.   NATURE

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

(2022) Katherine G. Nabel et al.   SCIENCE

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

(2022) Panpan Zhou et al.   Science Translational Medicine

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins

(2022) Zijun Wang et al.   IMMUNITY

Antibody-mediated neutralization of SARS-CoV-2

(2022) Henning Gruell et al.   IMMUNITY

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2

(2022) Ryuta Uraki et al.   NATURE

Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

(2022) Wan-ting He et al.   NATURE IMMUNOLOGY

COVID-19 vaccination: The road ahead

(2022) Daniel M. Altmann et al.   SCIENCE

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

(2022) Kathryn Westendorf et al.   Cell Reports

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

(2022) Wenjuan Du et al.   Science Immunology

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

(2021) Paul-Albert Koenig et al.   SCIENCE

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

(2021) Jiwan Ge et al.   Nature Communications

A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

(2021) Cheolmin Kim et al.   Nature Communications

The antigenic anatomy of SARS-CoV-2 receptor binding domain

(2021) Wanwisa Dejnirattisai et al.   CELL

A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

(2021) Qingrui Huang et al.   Nature Communications

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

(2021) Naveenchandra Suryadevara et al.   CELL

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

(2021) Matthew McCallum et al.   CELL

Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

(2021) Daniel Asarnow et al.   CELL

B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV

(2021) Johannes F. Scheid et al.   CELL

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

(2021) Pengfei Wang et al.   Cell Host & Microbe

COVID-19 mRNA vaccines

(2021) Qingrui Huang et al.   Journal of Genetics and Genomics

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Structural basis for broad coronavirus neutralization

(2021) Maximilian M. Sauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

(2021) Laith J. Abu-Raddad et al.   NEW ENGLAND JOURNAL OF MEDICINE

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

(2021) Bryan E. Jones et al.   Science Translational Medicine

COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

(2021) Opeyemi S. Adeniji et al.   mBio

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

(2021) Chunyan Wang et al.   Nature Communications

Tackling COVID-19 with neutralizing monoclonal antibodies

(2021) Davide Corti et al.   CELL

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

(2021) Richard Copin et al.   CELL

Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

(2021) Shuo Du et al.   CELL RESEARCH

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

(2021) Frauke Muecksch et al.   IMMUNITY

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

(2021) Ruoke Wang et al.   IMMUNITY

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

(2021) Mine Durusu Tanriover et al.   LANCET

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

(2021) Florian A. Lempp et al.   NATURE

Broad sarbecovirus neutralization by a human monoclonal antibody

(2021) M. Alejandra Tortorici et al.   NATURE

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

(2021) Tyler N. Starr et al.   NATURE

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

(2021) Paul T. Heath et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

(2021) Lingshu Wang et al.   SCIENCE

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

(2021) Meng Yuan et al.   SCIENCE

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study

(2021) Kathryn M. Hastie et al.   SCIENCE

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

(2021) Sophie M.-C. Gobeil et al.   SCIENCE

Broad betacoronavirus neutralization by a stem helix–specific human antibody

(2021) Dora Pinto et al.   SCIENCE

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

(2021) Dapeng Sun et al.   Nature Communications

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

(2021) Jinhui Dong et al.   Nature Microbiology

Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 Infection

(2021) Arnaud John Kombe Kombe et al.   Frontiers in Molecular Biosciences

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

(2021) Kanika Vanshylla et al.   Cell Host & Microbe

The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants

(2021) Chang Liu et al.   Cell Host & Microbe

Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

(2021) Yunlong Cao et al.   CELL RESEARCH

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

(2021) Deborah L. Burnett et al.   IMMUNITY

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Universal Coronavirus Vaccines — An Urgent Need

(2021) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

(2021) Matthew McCallum et al.   SCIENCE

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

(2021) David R. Martinez et al.   Science Translational Medicine

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

(2021) Obinna C. Ubah et al.   Nature Communications

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

(2021) Tingting Li et al.   Nature Communications

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

(2021) Wenwei Li et al.   Cell Reports

Stabilized coronavirus spike stem elicits a broadly protective antibody

(2021) Ching-Lin Hsieh et al.   Cell Reports

Distinct BCR repertoires elicited by SARS-CoV-2 RBD and S vaccinations in mice

(2021) Siyu Tian et al.   Cell Discovery

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Human neutralizing antibodies elicited by SARS-CoV-2 infection

(2020) Bin Ju et al.   NATURE

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

(2020) Lianpan Dai et al.   CELL

Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike

(2020) Jiandong Huo et al.   Cell Host & Microbe

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

(2020) Davide F. Robbiani et al.   NATURE

Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

(2020) Daming Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

(2020) Johanna Hansen et al.   SCIENCE

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

(2020) Zhe Lv et al.   SCIENCE

Distinct conformational states of SARS-CoV-2 spike protein

(2020) Yongfei Cai et al.   SCIENCE

Structural basis of a shared antibody response to SARS-CoV-2

(2020) Meng Yuan et al.   SCIENCE

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

(2020) Shuo Du et al.   CELL

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

(2020) Luca Piccoli et al.   CELL

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

(2020) Donald J. Benton et al.   NATURE

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

(2020) Christopher O. Barnes et al.   NATURE

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

(2020) Alina Baum et al.   SCIENCE

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity

(2020) Hejun Liu et al.   IMMUNITY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL