Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
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Title
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern
Authors
Keywords
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Journal
Cell Reports
Volume 38, Issue 2, Pages 110210
Publisher
Elsevier BV
Online
2021-12-16
DOI
10.1016/j.celrep.2021.110210
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Note: Only part of the references are listed.- A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent
- (2021) Tianshu Xiao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine
- (2021) Jerald Sadoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
- (2021) C. Garrett Rappazzo et al. SCIENCE
- Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
- (2021) Tyler N. Starr et al. SCIENCE
- Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry
- (2021) Jiwan Ge et al. Nature Communications
- The antigenic anatomy of SARS-CoV-2 receptor binding domain
- (2021) Wanwisa Dejnirattisai et al. CELL
- The great escape? SARS-CoV-2 variants evading neutralizing responses
- (2021) Jérémie Prévost et al. Cell Host & Microbe
- Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
- (2021) Zhuoming Liu et al. Cell Host & Microbe
- Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
- (2021) Allison J. Greaney et al. Cell Host & Microbe
- Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia
- (2021) Denis Y Logunov et al. LANCET
- N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
- (2021) Matthew McCallum et al. CELL
- SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
- (2021) Markus Hoffmann et al. CELL
- Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays
- (2021) Jingyou Yu et al. JOURNAL OF VIROLOGY
- Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England
- (2021) Erik Volz et al. NATURE
- Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies
- (2021) Delphine Planas et al. NATURE MEDICINE
- Structural basis for broad coronavirus neutralization
- (2021) Maximilian M. Sauer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19
- (2021) Jerald Sadoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
- (2021) Ge Song et al. Nature Communications
- A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
- (2021) Chunyan Wang et al. Nature Communications
- A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding
- (2021) Yingyi Long et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses
- (2021) Alexandra Tauzin et al. Cell Host & Microbe
- SnapShot: SARS-CoV-2 antibodies
- (2021) David C. Montefiori et al. Cell Host & Microbe
- Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
- (2021) Shuo Du et al. CELL RESEARCH
- Single-dose mRNA Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Including Alpha and Gamma Variants: A Test-negative Design in Adults 70 Years and Older in British Columbia, Canada
- (2021) Danuta M Skowronski et al. CLINICAL INFECTIOUS DISEASES
- Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021
- (2021) Finlay Campbell et al. Eurosurveillance
- Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
- (2021) Irfan Ullah et al. IMMUNITY
- Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
- (2021) Delphine Planas et al. NATURE
- Broad sarbecovirus neutralization by a human monoclonal antibody
- (2021) M. Alejandra Tortorici et al. NATURE
- Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
- (2021) Lingshu Wang et al. SCIENCE
- Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study
- (2021) Kathryn M. Hastie et al. SCIENCE
- Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
- (2021) Sophie M.-C. Gobeil et al. SCIENCE
- Broad betacoronavirus neutralization by a stem helix–specific human antibody
- (2021) Dora Pinto et al. SCIENCE
- Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
- (2021) Claudia A. Jette et al. Cell Reports
- Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects
- (2021) Madeleine F. Jennewein et al. Cell Reports
- Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2
- (2021) Chen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
- (2021) Tingting Li et al. Nature Communications
- Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants
- (2021) Tingting Li et al. Nature Communications
- An interactive web-based dashboard to track COVID-19 in real time
- (2020) Ensheng Dong et al. LANCET INFECTIOUS DISEASES
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
- (2020) Xiaolong Tian et al. Emerging Microbes & Infections
- Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses
- (2020) Michael Letko et al. Nature Microbiology
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2
- (2020) Alba Grifoni et al. Cell Host & Microbe
- Human neutralizing antibodies elicited by SARS-CoV-2 infection
- (2020) Bin Ju et al. NATURE
- Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
- (2020) Jun Lan et al. NATURE
- Structural basis of receptor recognition by SARS-CoV-2
- (2020) Jian Shang et al. NATURE
- A human monoclonal antibody blocking SARS-CoV-2 infection
- (2020) Chunyan Wang et al. Nature Communications
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- (2020) Xiuyuan Ou et al. Nature Communications
- Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
- (2020) Tyler N. Starr et al. CELL
- Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
- (2020) Christopher O. Barnes et al. CELL
- A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition
- (2020) M. Eugenia Dieterle et al. Cell Host & Microbe
- Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
- (2020) Fabian Schmidt et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
- (2020) Pedro M Folegatti et al. LANCET
- Convergent antibody responses to SARS-CoV-2 in convalescent individuals
- (2020) Davide F. Robbiani et al. NATURE
- Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
- (2020) Lihong Liu et al. NATURE
- Potently neutralizing and protective human antibodies against SARS-CoV-2
- (2020) Seth J. Zost et al. NATURE
- Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles
- (2020) Ze Li et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
- (2020) Ching-Lin Hsieh et al. SCIENCE
- Distinct conformational states of SARS-CoV-2 spike protein
- (2020) Yongfei Cai et al. SCIENCE
- Broad neutralization of SARS-related viruses by human monoclonal antibodies
- (2020) Anna Z. Wec et al. SCIENCE
- Molecular Architecture of the SARS-CoV-2 Virus
- (2020) Hangping Yao et al. CELL
- Structures and distributions of SARS-CoV-2 spike proteins on intact virions
- (2020) Zunlong Ke et al. NATURE
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges
- (2020) Beata Turoňová et al. SCIENCE
- Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
- (2020) M. Alejandra Tortorici et al. SCIENCE
- Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins
- (2020) Sai Priya Anand et al. Viruses-Basel
- Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals
- (2020) Guillaume Beaudoin-Bussières et al. mBio
- Opening the HIV envelope: potential of CD4 mimics as multifunctional HIV entry inhibitors
- (2020) Annemarie Laumaea et al. Current Opinion in HIV and AIDS
- Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles
- (2020) Maolin Lu et al. Cell Host & Microbe
- Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition
- (2020) Allison J. Greaney et al. Cell Host & Microbe
- Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects
- (2020) Hanh T. Nguyen et al. JOURNAL OF VIROLOGY
- Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
- (2020) Merryn Voysey et al. LANCET
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
- (2020) Lindsey R. Baden et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
- (2020) Fernando P. Polack et al. NEW ENGLAND JOURNAL OF MEDICINE
- Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
- (2020) Cong Xu et al. Science Advances
- Cell–cell and virus–cell fusion assay–based analyses of alanine insertion mutants in the distal α9 portion of the JRFL gp41 subunit from HIV-1
- (2019) Mizuki Yamamoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
- (2019) Alexandra C. Walls et al. CELL
- Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET
- (2019) Maolin Lu et al. NATURE
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
- (2019) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China
- (2018) Ning Wang et al. VIROLOGICA SINICA
- Automated tilt series alignment and tomographic reconstruction in IMOD
- (2017) David N. Mastronarde et al. JOURNAL OF STRUCTURAL BIOLOGY
- Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging
- (2017) Wim J.H. Hagen et al. JOURNAL OF STRUCTURAL BIOLOGY
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus
- (2017) S. J. Anthony et al. mBio
- Recent developments in the CCP-EM software suite
- (2017) Tom Burnley et al. Acta Crystallographica Section D-Structural Biology
- Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale
- (2016) Manuel F Juette et al. NATURE METHODS
- SAbPred: a structure-based antibody prediction server
- (2016) James Dunbar et al. NUCLEIC ACIDS RESEARCH
- SARS-like WIV1-CoV poised for human emergence
- (2016) Vineet D. Menachery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alignment of cryo-EM movies of individual particles by optimization of image translations
- (2015) John L. Rubinstein et al. JOURNAL OF STRUCTURAL BIOLOGY
- A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
- (2015) Vineet D Menachery et al. NATURE MEDICINE
- EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
- (2015) Benjamin A Barad et al. NATURE METHODS
- Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
- (2014) J. B. Munro et al. SCIENCE
- iMODFIT: Efficient and robust flexible fitting based on vibrational analysis in internal coordinates
- (2013) José Ramón Lopéz-Blanco et al. JOURNAL OF STRUCTURAL BIOLOGY
- Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
- (2013) Xing-Yi Ge et al. NATURE
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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