Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
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Title
Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
Authors
Keywords
SARS-CoV-2, epitope conservation, class 4 epitope site, cross-reactivity, neutralization, variants of concern, antigenic variation, escape mutations, next generation vaccines, human antibodies, mouse model
Journal
IMMUNITY
Volume 54, Issue 12, Pages 2908-2921.e6
Publisher
Elsevier BV
Online
2021-10-29
DOI
10.1016/j.immuni.2021.10.019
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