期刊
EMERGING MICROBES & INFECTIONS
卷 11, 期 1, 页码 2412-2422出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2022.2125348
关键词
SARS-CoV-2; neutralizing antibody; neutralizing mechanism; pan-coronavirus vaccine; antibody structure
资金
- National Natural Science Foundation of China [81901680]
The COVID-19 pandemic has led to devastating economic and public health consequences, prompting outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Understanding the antibody neutralizing mechanisms at the molecular and structural levels is critical for optimizing effective antibody-based therapeutics and developing next-generation pan-coronavirus vaccines.
The devastating economic and public health consequences caused by the COVID-19 pandemic have prompted outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Those efforts are encouraging and fruitful. An unprecedentedly large number of monoclonal antibodies (mAbs) targeting a large spectrum of epitopes on the spike protein has been developed in the last two years. The development of structural biology, especially the cryo-EM technology, provides structural insights into the molecular neutralizing mechanisms of those mAbs. Moreover, neutralizing antibodies are essential in protecting host from infection. Therefore, understanding the antibody neutralizing mechanism is critical for optimizing effective antibody-based therapeutics and developing next-generation pan-coronavirus vaccines. This review summarizes the latest understanding of antibody neutralizing mechanisms against SARS-CoV-2 at the molecular and structural levels.
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