An Overview of the Advances in Research on the Molecular Function and Specific Role of Circular RNA in Cardiovascular Diseases

Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR-138-5p-Mediated EGR1/TLR4/TRIF Inactivation

(2022) Chen Huang et al.   Oxidative Medicine and Cellular Longevity

The mitochondrial electron transport chain contributes to calpain 1 activation during ischemia-reperfusion

(2022) Qun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CircRNA and miRNA expression profiles during remote ischemic postconditioning attenuate brain ischemia/reperfusion injury

(2022) Chun-Yan Li et al.   BRAIN RESEARCH BULLETIN

Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR

(2022) Li Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circular RNAs and complex diseases: from experimental results to computational models

(2021) Chun-Chun Wang et al.   BRIEFINGS IN BIOINFORMATICS

Circular RNAs: Emerging Regulators of the Major Signaling Pathways Involved in Cancer Progression

(2021) Maria Papatsirou et al.   Cancers

The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair

(2020) Qian Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-κB axis in endothelial cells

(2020) Hua-shan Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comprehensive circRNA expression profile and construction of circRNA-related ceRNA network in cardiac fibrosis

(2020) Xia Gu et al.   BIOMEDICINE & PHARMACOTHERAPY

The Circular RNA CDR1as Regulates the Proliferation and Apoptosis of Human Cardiomyocytes Through the miR-135a/HMOX1 and miR-135b/HMOX1 Axes

(2020) Cheng Chen et al.   Genetic Testing and Molecular Biomarkers

circANRIL reduces vascular endothelial injury, oxidative stress and inflammation in rats with coronary atherosclerosis

(2020) Peixia Shi et al.   Experimental and Therapeutic Medicine

CircANXA2 Promotes Myocardial Apoptosis in Myocardial Ischemia-Reperfusion Injury via Inhibiting miRNA-133 Expression

(2020) Liang Zong et al.   Biomed Research International

Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis

(2020) Jianqiang Kou et al.   Biomed Research International

CircRNA ZNF609 in peripheral blood leukocytes acts as a protective factor and a potential biomarker for coronary artery disease

(2020) Bin Liang et al.   Annals of Translational Medicine

Deep-belief network for predicting potential miRNA-disease associations

(2020) Xing Chen et al.   BRIEFINGS IN BIOINFORMATICS

Research on the circular RNA bioinformatics in patients with acute myocardial infarction

(2020) Lianli Yin et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

The role of circular RNAs in therapy resistance of patients with solid tumors

(2020) Maria Papatsirou et al.   Personalized Medicine

Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis

(2020) Tao Liu et al.   Biomed Research International

The microarray identification circular RNA hsa_circ_0105015 up‐regulated involving inflammation pathway in essential hypertension

(2020) Xin He et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy

(2020) Jinshan Suo et al.   Biomed Research International

Circ_Lrp6, a Circular RNA Enriched in Vascular Smooth Muscle Cells, Acts as a Sponge Regulating miRNA-145 Function

(2019) Ignacio Fernando Hall et al.   CIRCULATION RESEARCH

Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury

(2019) Pengpeng Zhang et al.   Scientific Reports

circ-Sirt1 controls NF-κB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells

(2019) Peng Kong et al.   NUCLEIC ACIDS RESEARCH

circRNA‑miRNA association for coronary heart disease

(2019) Fei Lin et al.   Molecular Medicine Reports

Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p

(2019) Huaner Ni et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

(2019) Lei Yang et al.   Molecular Therapy-Nucleic Acids

Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-κB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197

(2019) Jie Cheng et al.   GENE

Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis

(2019) Qiang Su et al.   GENOMICS

Integrating Bipartite Network Projection and KATZ Measure to Identify Novel CircRNA-Disease Associations

(2019) Qi Zhao et al.   IEEE TRANSACTIONS ON NANOBIOSCIENCE

NCMCMDA: miRNA–disease association prediction through neighborhood constraint matrix completion

(2019) Xing Chen et al.   BRIEFINGS IN BIOINFORMATICS

Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons

(2018) Simona Aufiero et al.   RNA

circRNA disease: a manually curated database of experimentally supported circRNA-disease associations

(2018) Zheng Zhao et al.   Cell Death & Disease

CircR2Disease: a manually curated database for experimentally supported circular RNAs associated with various diseases

(2018) Chunyan Fan et al.   Database-The Journal of Biological Databases and Curation

A 360° view of circular RNAs: From biogenesis to functions

(2018) Jeremy E. Wilusz   Wiley Interdisciplinary Reviews-RNA

Circ2Disease: a manually curated database of experimentally validated circRNAs in human disease

(2018) Dongxia Yao et al.   Scientific Reports

The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway

(2018) Lu-Yu Zhou et al.   CELL DEATH AND DIFFERENTIATION

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

(2017) Meng-Yu Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease

(2017) D. Siede et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients

(2017) Ren-You Pan et al.   Oncotarget

Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease

(2017) Zhenzhou Zhao et al.   Scientific Reports

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

(2017) Yan Zeng et al.   Theranostics

Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction

(2017) Chang Liu et al.   Theranostics

Circular RNAs in Cardiovascular Disease: An Overview

(2017) Ximin Fan et al.   Biomed Research International

Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 LevelsCLINICAL PERSPECTIVE

(2017) Hernan A. Bazan et al.   Circulation-Cardiovascular Genetics

Circular RNAs (circRNAs) in Health and Disease

(2017) et al.   Genes

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

(2017) Shashi Kumar Gupta et al.   CIRCULATION RESEARCH

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses

(2016) William W. Du et al.   EUROPEAN HEART JOURNAL

A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223

(2016) Kun Wang et al.   EUROPEAN HEART JOURNAL

Role of neutrophils in atherogenesis: an update

(2016) Aldo Pende et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung’s disease

(2016) Lei Peng et al.   Oncotarget

The Biogenesis of Nascent Circular RNAs

(2016) Yang Zhang et al.   Cell Reports

The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression

(2016) Hai-Hua Geng et al.   PLoS One

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation

(2016) Qiang Liu et al.   Scientific Reports

circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

(2016) Xiaoping Chen et al.   Scientific Reports

Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNANovelty and Significance

(2015) Jes-Niels Boeckel et al.   CIRCULATION RESEARCH

Update on the Role of Neutrophils in Atherosclerotic Plaque Vulnerability

(2015) Federico Carbone et al.   CURRENT DRUG TARGETS

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture

(2015) Hernan A. Bazan et al.   STROKE

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development

(2015) Linda Szabo et al.   GENOME BIOLOGY

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

Efficient backsplicing produces translatable circular mRNAs

(2014) Yang Wang et al.   RNA

Inflammation and Atherosclerosis—Revisited

(2013) Sadip Pant et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry