The role of circular RNAs in therapy resistance of patients with solid tumors

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

(2020) Fan Zhou et al.   BMC CANCER

A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR‐182‐5p

(2020) Xiao‐xu Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340

(2020) Xiangyu Jian et al.   Molecular Cancer

Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

(2020) Xiaohong Hong et al.   Molecular Cancer

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

(2020) Xinyi Wang et al.   Molecular Oncology

Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis

(2020) Zhihui Wu et al.   BMC Pulmonary Medicine

CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1

(2020) Yunfei Liu et al.   Cancer Management and Research

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

(2020) Águeda Martínez-Barriocanal et al.   Frontiers in Oncology

CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis

(2020) Fushuang Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

CircAKT3 inhibits glycolysis balance in lung cancer cells by regulating miR-516b-5p/STAT3 to inhibit cisplatin sensitivity

(2020) Yangling Xu et al.   BIOTECHNOLOGY LETTERS

Circ-ABCB10 Contributes to Paclitaxel Resistance in Breast Cancer Through Let-7a-5p/DUSP7 Axis

(2020) Weiping Yang et al.   Cancer Management and Research

Mechanism of the Regulatory Effect of Overexpression of circMTO1 on Proliferation and Apoptosis of Hepatoma Cells via miR-9-5p/NOX4 Axis

(2020) Jinbao Wang et al.   Cancer Management and Research

Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance

(2020) Ya-Chi Lin et al.   Cancers

Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma

(2020) Chenyu Ding et al.   CANCER LETTERS

Analyzing the interactions of mRNAs, miRNAs, lncRNAs and circRNAs to predict competing endogenous RNA networks in osteosarcoma chemo-resistance

(2019) Kun-Peng Zhu et al.   MOLECULAR THERAPY

TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

(2019) Veenu Tripathi et al.   ONCOGENE

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

(2019) Yi-Hua Jan et al.   Journal of Hematology & Oncology

hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway

(2019) Minghui Xue et al.   Cancer Cell International

CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis

(2019) Li Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

(2019) Xiaoxu Huang et al.   Molecular Cancer

Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF 1 expression through miR‐1270 inhibition

(2019) Wenbo Yuan et al.   Molecular Oncology

circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer

(2019) Yuting Sang et al.   MOLECULAR THERAPY

Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells

(2019) Wanjun Yu et al.   ONCOLOGY RESEARCH

Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer

(2019) Nadiah Abu et al.   Epigenomics

CircRNA_0025202 regulates tamoxifen sensitivity and tumor progression via regulating the miR-182-5p/FOXO3a axis in breast cancer

(2019) Yuting Sang et al.   Molecular Therapy-Nucleic Acids

Hsa_circ_0023404 enhances cervical cancer metastasis and chemoresistance through VEGFA and autophagy signaling by sponging miR-5047

(2019) Jing Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Silencing CDR1as enhances the sensitivity of breast cancer cells to drug resistance by acting as a miR-7 sponge to down-regulate REGγ

(2019) Wei Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide

(2019) John Greene et al.   Scientific Reports

Circular RNA screening from EIF3a in lung cancer

(2019) Ma‐Sha Huang et al.   Cancer Medicine

Circular RNA Cdr1as upregulates SCAI to suppress cisplatin resistance in Ovarian Cancer via miR-1270 suppression

(2019) Zhao Zhao et al.   Molecular Therapy-Nucleic Acids

Emerging Epigenetic Regulation of Circular RNAs in Human Cancer

(2019) Jie Wu et al.   Molecular Therapy-Nucleic Acids

circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893

(2019) Mengmeng Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Knockdown of cZNF292 suppressed hypoxic human hepatoma SMMC7721 cell proliferation, vasculogenic mimicry, and radioresistance

(2019) Wei Yang et al.   CELLULAR SIGNALLING

circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer

(2019) Yiran Liang et al.   ONCOGENE

Serum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer

(2019) Wei Wang et al.   OncoTargets and Therapy

Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation

(2019) Lei Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling

(2019) Weimei Huang et al.   CELL DEATH AND DIFFERENTIATION

Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA‐424 in osteosarcoma

(2019) Yuhang Hu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

circMTDH.4/miR‐630/AEG‐1 axis participates in the regulation of proliferation, migration, invasion, chemoresistance, and radioresistance of NSCLC

(2019) Ying‐Hong Li et al.   MOLECULAR CARCINOGENESIS

circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma

(2019) Hang Chen et al.   OncoTargets and Therapy

Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells

(2019) Jian Ma et al.   Aging-US

Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p/REGγ axis

(2019) Chunfeng Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma

(2019) Yuqiang Mao et al.   BIOMEDICINE & PHARMACOTHERAPY

Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through regulates ZEB1 expression by sponging miR-124-3p

(2019) Yan-yan Liu et al.   BIOSCIENCE REPORTS

Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel

(2019) Zhiyuan Shen et al.   CANCER LETTERS

Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma

(2019) Chengbin Zhao et al.   INVESTIGATIONAL NEW DRUGS

Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma

(2019) Qi Lu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Circ_0076305 regulates cisplatin resistance of non-small cell lung cancer via positively modulating STAT3 by sponging miR-296–5p

(2019) Yu Dong et al.   LIFE SCIENCES

miR-7 Reverses Breast Cancer Resistance To Chemotherapy By Targeting MRP1 And BCL2

(2019) Tianzi Hong et al.   OncoTargets and Therapy

Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p

(2019) Xiaoping Li et al.   Cell Death & Disease

circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252

(2019) Shu Zhang et al.   Molecular Therapy-Nucleic Acids

Functional relevance of SATB1 in immune regulation and tumorigenesis

(2018) Krishna P. Sunkara et al.   BIOMEDICINE & PHARMACOTHERAPY

Circular RNAs (circRNAs) in cancer

(2018) Ruoyu Zhou et al.   CANCER LETTERS

Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells

(2018) Yongyan Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer

(2018) Yunlu Jia et al.   CELLULAR SIGNALLING

Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1

(2018) Zhu Kun-Peng et al.   International Journal of Biological Sciences

Molecular Markers of Therapy-Resistant Glioblastoma and Potential Strategy to Combat Resistance

(2018) Ha Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Research progress on the regulation of tumor initiation and development by the forkhead box Q1 gene

(2018) Qiang Guo et al.   Journal of Cancer Research and Therapeutics

Forkhead-box R2 promotes metastasis and growth by stimulating angiogenesis and activating hedgehog signaling pathway in ovarian cancer

(2018) Bing Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells

(2018) Nithila A. Joseph et al.   Journal of Hematology & Oncology

Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer

(2018) K. Uhr et al.   Scientific Reports

Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma

(2018) Feng Shao et al.   Frontiers in Pharmacology

Hypoxic Signalling in Tumour Stroma

(2018) Anu Laitala et al.   Frontiers in Oncology

ABC transporters as cancer drivers: Potential functions in cancer development

(2018) Alice Domenichini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

(2018) Ning Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Critical role of FOXO3a in carcinogenesis

(2018) Ying Liu et al.   Molecular Cancer

Screening circular RNA related to chemotherapeutic resistance in osteosarcoma by RNA sequencing

(2018) Zhu Kun-Peng et al.   Epigenomics

Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation

(2018) Feng Liu et al.   Aging-US

Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway

(2018) You Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy

(2018) Akshay Malhotra et al.   BIOCHIMIE

Autophagy, Cancer Stem Cells & Drug Resistance

(2018) Alexandra G. Smith et al.   JOURNAL OF PATHOLOGY

Inhibition of hsa_circ_0001313 (circCCDC66) induction enhances the radio-sensitivity of colon cancer cells via tumor suppressor miR-338-3p

(2018) Li Wang et al.   PATHOLOGY RESEARCH AND PRACTICE

miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2

(2018) Qiuyan Zhao et al.   Cell Death & Disease

CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway

(2018) Yunlong He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation

(2017) Yuhan Chen et al.   GENE

The future of personalised radiotherapy for head and neck cancer

(2017) Jimmy J Caudell et al.   LANCET ONCOLOGY

Translation of CircRNAs

(2017) Nagarjuna Reddy Pamudurti et al.   MOLECULAR CELL

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

Chemoresistance in cancer cells: exosomes as potential regulators of therapeutic tumor heterogeneity

(2017) Aman Sharma   Nanomedicine

TRAF4 Regulates Migration, Invasion, and Epithelial‐Mesenchymal Transition via PI3K/AKT Signaling in Hepatocellular Carcinoma

(2017) Kairui Liu et al.   ONCOLOGY RESEARCH

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Engineering and expressing circular RNAs via tRNA splicing

(2017) John J. Noto et al.   RNA Biology

Screening circular RNA related to chemotherapeutic resistance in breast cancer

(2017) Danfeng Gao et al.   Epigenomics

Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor–Positive Breast Cancer

(2017) Karina J. Matissek et al.   Cancer Discovery

Astrocyte elevated gene-1 is overexpressed in non-small-cell lung cancer and associated with increased tumour angiogenesis

(2017) Qiuping Ding et al.   Interactive Cardiovascular and Thoracic Surgery

Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells

(2017) Wei Xiong et al.   Biomed Research International

CircRNA-derived pseudogenes

(2016) Rui Dong et al.   CELL RESEARCH

Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells

(2016) Huafang Su et al.   Journal of Translational Medicine

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment

(2016) Shanthi Marur et al.   MAYO CLINIC PROCEEDINGS

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

(2016) Rebecca Kring Hansen et al.   NATURE CELL BIOLOGY

The epigenetic landscape of renal cancer

(2016) Mark R. Morris et al.   Nature Reviews Nephrology

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells

(2016) Yong Lin et al.   Oncotarget

circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations

(2016) Xiaoping Chen et al.   Scientific Reports

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Molecular mechanisms of drug resistance and its reversal in cancer

(2015) Melis Kartal-Yandim et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sp1 transcription factor: A long-standing target in cancer chemotherapy

(2015) Carolina Vizcaíno et al.   PHARMACOLOGY & THERAPEUTICS

Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation

(2015) Mahmoud Toulany et al.   SEMINARS IN CANCER BIOLOGY

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Circular RNA biogenesis can proceed through an exon-containing lariat precursor

(2015) Steven P Barrett et al.   eLife

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

(2015) Sebastian Memczak et al.   PLoS One

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

TRAF4 promotes tumorigenesis of breast cancer through activation of Akt

(2014) JIE ZHANG et al.   ONCOLOGY REPORTS

TRAF4 Enhances Osteosarcoma Cell Proliferation and Invasion by Akt Signaling Pathway

(2014) Weitao Yao et al.   ONCOLOGY RESEARCH

Down Regulation of Wnt Signaling Mitigates Hypoxia-Induced Chemoresistance in Human Osteosarcoma Cells

(2014) Donald J. Scholten et al.   PLoS One

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

The ABCG2 resistance network of glioblastoma

(2011) Anne-Marie Bleau et al.   CELL CYCLE

microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling

(2011) Kyung Min Lee et al.   RADIOTHERAPY AND ONCOLOGY

The Chromosomal Instability Pathway in Colon Cancer

(2010) Maria S. Pino et al.   GASTROENTEROLOGY