Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses

(2021) Cathrine Nordgaard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Translation stress and collided ribosomes are co-activators of cGAS

(2021) Li Wan et al.   MOLECULAR CELL

GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

(2020) Kelsey L. Hickey et al.   MOLECULAR CELL

Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

(2020) Szymon Juszkiewicz et al.   eLife

EDF1 coordinates cellular responses to ribosome collisions

(2020) Niladri K Sinha et al.   eLife

Causes and consequences of RNA polymerase II stalling during transcript elongation

(2020) Melvin Noe Gonzalez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

(2019) Maxim A.X. Tollenaere et al.   Cell Reports

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation

(2019) Ana Tufegdzic Vidakovic et al.   METHODS

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

(2019) Lea H. Gregersen et al.   CELL

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction

(2019) Halley B. Rycenga et al.   Scientific Reports

Molecular basis for GIGYF–Me31B complex assembly in 4EHP-mediated translational repression

(2019) Daniel Peter et al.   GENES & DEVELOPMENT

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

The Cellular Response to Transcription-Blocking DNA Damage

(2018) Lea H. Gregersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

(2017) Daniel Peter et al.   GENES & DEVELOPMENT

Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage

(2017) Juston C. Weems et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor

(2016) Liang Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DrosophilaGyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis

(2015) Myungjin Kim et al.   Autophagy

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

(2015) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation

(2015) Anne Lafon et al.   MOLECULAR CELL

Reconstitution of a Minimal Ribosome-Associated Ubiquitination Pathway with Purified Factors

(2014) Sichen Shao et al.   MOLECULAR CELL

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress

(2013) Marcus D. Wilson et al.   CELL

Perturbations to the Ubiquitin Conjugate Proteome in Yeast ΔubxMutants Identify Ubx2 as a Regulator of Membrane Lipid Composition

(2013) Natalie Kolawa et al.   MOLECULAR & CELLULAR PROTEOMICS

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

(2012) M. Morita et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

MultiDsk: A Ubiquitin-Specific Affinity Resin

(2012) Marcus D. Wilson et al.   PLoS One

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

(2011) Leslie Magtanong et al.   NATURE BIOTECHNOLOGY

The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23

(2010) Batool Ossareh-Nazari et al.   EXPERIMENTAL CELL RESEARCH

COPII-mediated vesicle formation at a glance

(2010) D. Jensen et al.   JOURNAL OF CELL SCIENCE

The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity

(2010) Y.-L. Cheng et al.   JOURNAL OF CELL SCIENCE

The SESA network links duplication of the yeast centrosome with the protein translation machinery

(2009) B. Sezen et al.   GENES & DEVELOPMENT

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

(2009) M. Harreman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

(2008) C. Schuberth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1

(2008) Takashi Yasukawa et al.   EMBO JOURNAL

A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin

(2008) O. Aygun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smy2p Participates in COPII Vesicle Formation Through the Interaction with Sec23p/Sec24p Subcomplex

(2008) Hironori Higashio et al.   TRAFFIC