Controllable crRNA Self-Transcription Aided Dual-Amplified CRISPR-Cas12a Strategy for Highly Sensitive Biosensing of FEN1 Activity

Development of a CRISPR-Cas-Based Biosensor for Rapid and Sensitive Detection of 8-Oxoguanine DNA Glycosylase

(2022) Qian Zhang et al.   ANALYTICAL CHEMISTRY

Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review)

(2022) Julija Dronina et al.   JOURNAL OF NANOBIOTECHNOLOGY

A one-pot CRISPR/Cas13a-based contamination-free biosensor for low-cost and rapid nucleic acid diagnostics

(2022) Fei Hu et al.   BIOSENSORS & BIOELECTRONICS

Holographic Optical Tweezers and Boosting Upconversion Luminescent Resonance Energy Transfer Combined Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas12a Biosensors

(2021) Cheng-Yu Li et al.   ACS Nano

Dual-Mode FEN1 Activity Detection Based on Nt.BstNBI-Induced Tandem Signal Amplification

(2021) Haitang Yang et al.   ANALYTICAL CHEMISTRY

An ultrasensitive CRISPR/Cas12a based electrochemical biosensor for Listeria monocytogenes detection

(2021) Fan Li et al.   BIOSENSORS & BIOELECTRONICS

CRISPR-Based COVID-19 Testing: Toward Next-Generation Point-of-Care Diagnostics

(2021) Uyanga Ganbaatar et al.   Frontiers in Cellular and Infection Microbiology

Aptamer assisted CRISPR-Cas12a strategy for small molecule diagnostics

(2021) Chenqi Niu et al.   BIOSENSORS & BIOELECTRONICS

Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing

(2021) Jiajing Guo et al.   ACS Central Science

Controlling the trans-cleavage of CRISPR-Cas12a with nicked PAM: Universal platform for biosensing

(2021) Decai Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Advances and insights in the diagnosis of viral infections

(2021) Julija Dronina et al.   JOURNAL OF NANOBIOTECHNOLOGY

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

(2020) Koen D. Flach et al.   CANCER RESEARCH

Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer

(2020) Xing Xin et al.   Frontiers in Oncology

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

(2020) Susan E. Tsutakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR-derived biosensor for the sensitive detection of transcription factors based on the target-induced inhibition of Cas12a activation

(2020) Bingzhi Li et al.   BIOSENSORS & BIOELECTRONICS

Terminal deoxynucleotidyl transferase induced activators to unlock the trans-cleavage of CRISPR/Cpf 1 (TdT-IU- CRISPR/Cpf 1): An ultrasensitive biosensor for Dam MTase activity detection

(2020) Xiaolong Chen et al.   BIOSENSORS & BIOELECTRONICS

Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background

(2020) Yi-Chen Du et al.   BIOSENSORS & BIOELECTRONICS

The application of DNA polymerases and Cas9 as representative of DNA-modifying enzymes group in DNA sensor design (review)

(2020) Julija Dronina et al.   BIOSENSORS & BIOELECTRONICS

CRISPR/Cas Systems towards Next-Generation Biosensing

(2019) Yi Li et al.   TRENDS IN BIOTECHNOLOGY

Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells

(2019) Long Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

(2019) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

(2019) Mindong Liang et al.   Nature Communications

FEN1 inhibitor increases sensitivity of radiotherapy in cervical cancer cells

(2019) Jin‐Li Li et al.   Cancer Medicine

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems

(2018) Hao Zhang et al.   NANO LETTERS

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer-template models and exploration of a substrate-based FEN1 inhibitor

(2016) Sai Ba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression

(2016) Lingfeng He et al.   EBioMedicine

Cancer biomarker detection: recent achievements and challenges

(2015) Li Wu et al.   CHEMICAL SOCIETY REVIEWS

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Functional FEN1 genetic variants and haplotypes are associated with glioma risk

(2012) Yi-Dong Chen et al.   JOURNAL OF NEURO-ONCOLOGY

FEN Nucleases: Bind, Bend, Fray, Cut

(2011) R. Scott Williams et al.   CELL