Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability

SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair

(2019) Ming Tang et al.   Science Advances

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transketolase deficiency protects the liver from DNA damage by increasing levels of ribose 5-phosphate and nucleotides

(2019) Minle Li et al.   CANCER RESEARCH

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis

(2019) Yuanzhen Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

(2019) GuoXiao Wang et al.   MOLECULAR CELL

SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway

(2019) Xiaodan Sun et al.   Frontiers in Oncology

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

(2019) Kai Su Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles for SIRT5 in Metabolism and Cancer

(2018) Lauren R. Bringman-Rodenbarger et al.   ANTIOXIDANTS & REDOX SIGNALING

Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the α-Ketoglutarate Signaling Pathway

(2018) Chien-Wei Tseng et al.   CANCER RESEARCH

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

(2018) Yun-Qian Wang et al.   Nature Communications

Targeting a Sirt5-Positive Subpopulation Overcomes Multidrug Resistance in Wild-Type Kras Colorectal Carcinomas

(2018) ZunGuo Du et al.   Cell Reports

Glyceraldehyde 3-phosphate dehydrogenase modulates non-oxidative pentose phosphate pathway to provide anabolic precursors in hypoxic tumor cells

(2018) Woo Suk Ahn et al.   AICHE JOURNAL

The roles of sirtuins family in cell metabolism during tumor development

(2018) Shunqin Zhu et al.   SEMINARS IN CANCER BIOLOGY

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

Transketolase counteracts oxidative stress to drive cancer development

(2016) Iris Ming-Jing Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

A key role for transketolase-like 1 in tumor metabolic reprogramming

(2016) Santiago Diaz-Moralli et al.   Oncotarget

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

(2016) Hui Zhang et al.   Cell Reports

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

(2015) Michele Cea et al.   BLOOD

Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair

(2015) Jessica L. Alexander et al.   CURRENT BIOLOGY

Preventing replication fork collapse to maintain genome integrity

(2015) David Cortez   DNA REPAIR

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

(2015) Yuya Nishida et al.   MOLECULAR CELL

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

(2015) Lindsey N. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis

(2014) Arindam Saha et al.   MOLECULAR CELL

A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

(2014) Tongzheng Liu et al.   MOLECULAR CELL

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine

(2012) S. Prasad et al.   CLINICAL CANCER RESEARCH

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL