BRAT1 links Integrator and defective RNA processing with neurodegeneration
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
BRAT1 links Integrator and defective RNA processing with neurodegeneration
Authors
Keywords
-
Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-08-26
DOI
10.1038/s41467-022-32763-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Integrator is a genome-wide attenuator of non-productive transcription
- (2021) Søren Lykke-Andersen et al. MOLECULAR CELL
- Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator
- (2021) Aishwarya Gurumurthy et al. NUCLEIC ACIDS RESEARCH
- Structure of the catalytic core of the Integrator complex
- (2021) Moritz M. Pfleiderer et al. MOLECULAR CELL
- Disruption of pathways regulated by Integrator complex in Galloway–Mowat syndrome due to WDR73 mutations
- (2021) F. C. Tilley et al. Scientific Reports
- Novel variant in BRAT1 with the lethal neonatal rigidity and multifocal seizure syndrome
- (2021) Weixi Li et al. PEDIATRIC RESEARCH
- INTS11 regulates hematopoiesis by promoting PRC2 function
- (2021) Peng Zhang et al. Science Advances
- Clinical variability at the mild end of BRAT1 ‐related spectrum: Evidence from two families with genotype–phenotype discordance
- (2021) Sara Nuovo et al. HUMAN MUTATION
- Structure of an active human histone pre-mRNA 3′-end processing machinery
- (2020) Yadong Sun et al. SCIENCE
- The Integrator Complex in Transcription and Development
- (2020) María Saraí Mendoza-Figueroa et al. TRENDS IN BIOCHEMICAL SCIENCES
- INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module
- (2020) Kevin Sabath et al. Nature Communications
- The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts
- (2020) Felipe Beckedorff et al. Cell Reports
- Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1
- (2020) Jasmine Barra et al. Science Advances
- Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
- (2020) Kai-Lieh Huang et al. MOLECULAR CELL
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
- (2020) Hai Zheng et al. SCIENCE
- Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies
- (2019) Max Krall et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes
- (2019) Eva Gómez-Orte et al. PLoS Genetics
- Integrator is a key component of human telomerase RNA biogenesis
- (2019) M. P. Rubtsova et al. Scientific Reports
- The Integrator complex cleaves nascent mRNAs to attenuate transcription
- (2019) Deirdre C. Tatomer et al. GENES & DEVELOPMENT
- BRAT 1 encephalopathy: a recessive cause of epilepsy of infancy with migrating focal seizures
- (2019) Ingrid E Scheffer et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes
- (2019) Nathan D. Elrod et al. MOLECULAR CELL
- Exome sequencing in congenital ataxia identifies two new candidate genes and highlights a pathophysiological link between some congenital ataxias and early infantile epileptic encephalopathies
- (2018) Stéphanie Valence et al. GENETICS IN MEDICINE
- Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals
- (2018) Nilay Shah et al. MOLECULAR CELL
- Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
- (2018) Todd R Albrecht et al. NUCLEIC ACIDS RESEARCH
- Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence
- (2018) Takayuki Nojima et al. MOLECULAR CELL
- Ensembl 2019
- (2018) Fiona Cunningham et al. NUCLEIC ACIDS RESEARCH
- Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance
- (2017) Yixuan Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Special focus on the Cajal Body
- (2017) Karla M. Neugebauer RNA Biology
- Human mutations in integrator complex subunits link transcriptome integrity to brain development
- (2017) Renske Oegema et al. PLoS Genetics
- The Perseus computational platform for comprehensive analysis of (prote)omics data
- (2016) Stefka Tyanova et al. NATURE METHODS
- YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
- (2016) Shawn M. Lyons et al. NUCLEIC ACIDS RESEARCH
- Cajal bodies and snRNPs - friends with benefits
- (2016) David Staněk RNA Biology
- BRAT1-related disease-identification of a patient without early lethality
- (2015) Sheraden A. Mundy et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Lethal neonatal rigidity and multifocal seizure syndrome – Report of another family with a BRAT1 mutation
- (2015) Rachel Straussberg et al. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
- Integrator mediates the biogenesis of enhancer RNAs
- (2015) Fan Lai et al. NATURE
- HISAT: a fast spliced aligner with low memory requirements
- (2015) Daehwan Kim et al. NATURE METHODS
- Lethal Neonatal Rigidity and Multifocal Seizure Syndrome—A Misnamed Disorder?
- (2015) Ilana Hanes et al. PEDIATRIC NEUROLOGY
- Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
- (2014) Jürgen Cox et al. MOLECULAR & CELLULAR PROTEOMICS
- Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes
- (2014) Bernd Stadelmayer et al. Nature Communications
- featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
- (2013) Y. Liao et al. BIOINFORMATICS
- The One Hour Yeast Proteome
- (2013) Alexander S. Hebert et al. MOLECULAR & CELLULAR PROTEOMICS
- A Subset of Histone H2B Genes Produces Polyadenylated mRNAs under a Variety of Cellular Conditions
- (2013) Vijayalakshmi Kari et al. PLoS One
- The Integrator Complex Subunit 6 (Ints6) Confines the Dorsal Organizer in Vertebrate Embryogenesis
- (2013) Lee D. Kapp et al. PLoS Genetics
- Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration
- (2012) Yichang Jia et al. CELL
- The integrator complex is required for integrity of Cajal bodies
- (2012) H. Takata et al. JOURNAL OF CELL SCIENCE
- snRNA 3' End Formation Requires Heterodimeric Association of Integrator Subunits
- (2012) T. R. Albrecht et al. MOLECULAR AND CELLULAR BIOLOGY
- Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases
- (2012) Erik G. Puffenberger et al. PLoS One
- An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation
- (2012) J. Chen et al. RNA
- Association of TALS Developmental Disorder with Defect in Minor Splicing Component U4atac snRNA
- (2011) P. Edery et al. SCIENCE
- Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit
- (2011) EUI YOUNG SO et al. Experimental and Therapeutic Medicine
- Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing
- (2010) Judith Pirngruber et al. CELL CYCLE
- A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation
- (2010) N. Ezzeddine et al. MOLECULAR AND CELLULAR BIOLOGY
- The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling
- (2009) S. Tao et al. DEVELOPMENT
- Phenotypic analysis ofdeflated/Ints7 function inDrosophiladevelopment
- (2009) Rachael J. Rutkowski et al. DEVELOPMENTAL DYNAMICS
- Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis
- (2008) Takeshi Masuda et al. JOURNAL OF PROTEOME RESEARCH
- Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
- (2008) William F. Marzluff et al. NATURE REVIEWS GENETICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now