Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis

(2020) Xiaoli Li et al.   Frontiers in Pharmacology

ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

(2019) Erik A. Blackwood et al.   CIRCULATION RESEARCH

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

(2019) Erik A. Blackwood et al.   Nature Communications

Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia

(2019) Kiwako Mori et al.   Scientific Reports

The role of the BMP4/Smad1 signaling pathway in mesangial cell proliferation: A possible mechanism of diabetic nephropathy

(2019) Cheng Chen et al.   LIFE SCIENCES

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

(2019) Sandhya Chipurupalli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells

(2019) Shoujian Wang et al.   EXPERIMENTAL EYE RESEARCH

Scleral hypoxia is a target for myopia control

(2018) Hao Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A highly efficient murine model of experimental myopia

(2018) Xiaoyan Jiang et al.   Scientific Reports

PERK regulates skeletal muscle mass and contractile function in adult mice

(2018) Yann S. Gallot et al.   FASEB JOURNAL

Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

(2017) Hidemasa Torii et al.   EBioMedicine

Interferon-γ–Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome

(2016) Terry G. Coursey et al.   AMERICAN JOURNAL OF PATHOLOGY

4-Phenylbutyric acid reduces mutant-TGFBIp levels and ER stress through activation of ERAD pathway in corneal fibroblasts of granular corneal dystrophy type 2

(2016) Seung-il Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia

(2016) Kyle R. Bohnert et al.   FASEB JOURNAL

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

(2016) Lars Plate et al.   eLife

Association of Axial Length With Risk of Uncorrectable Visual Impairment for Europeans With Myopia

(2016) J. Willem L. Tideman et al.   JAMA Ophthalmology

The dynamic sclera: Extracellular matrix remodeling in normal ocular growth and myopia development

(2015) Angelica R. Harper et al.   EXPERIMENTAL EYE RESEARCH

The myopia boom

(2015) Elie Dolgin   NATURE

Transmission of ER stress response by ATF6 promotes endochondral bone growth

(2015) Zhangyuan Xiong et al.   Journal of Orthopaedic Surgery and Research

XBP1S, a BMP2-inducible transcription factor, accelerates endochondral bone growth by activating GEP growth factor

(2014) Feng-Jin Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

The ALK-1/Smad1 pathway in cardiovascular physiopathology. A new target for therapy?

(2013) María González-Núñez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

(2013) Tokiro Ishikawa et al.   MOLECULAR BIOLOGY OF THE CELL

Mild Endoplasmic Reticulum Stress Promotes Retinal Neovascularization via Induction of BiP/GRP78

(2013) Shinsuke Nakamura et al.   PLoS One

Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling

(2012) Simon R. Stockwell et al.   PLoS One

The complex interactions of retinal, optical and environmental factors in myopia aetiology

(2012) D.I. Flitcroft   PROGRESS IN RETINAL AND EYE RESEARCH

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

Nelfinavir Induces Liposarcoma Apoptosis through Inhibition of Regulated Intramembrane Proteolysis of SREBP-1 and ATF6

(2011) M. Guan et al.   CLINICAL CANCER RESEARCH

Transcriptional Profiling of Chondrodysplasia Growth Plate Cartilage Reveals Adaptive ER-Stress Networks That Allow Survival but Disrupt Hypertrophy

(2011) Trevor L. Cameron et al.   PLoS One

Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes

(2010) K.W. Finnson et al.   OSTEOARTHRITIS AND CARTILAGE

Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy

(2009) Jingming Li et al.   FEBS LETTERS

The role of the unfolded protein response in the heart

(2007) Christopher C. Glembotski   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY