CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis

Endoplasmic Reticulum Stress Promotes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate PD-L1 Expression in Macrophages

(2019) Jiatao Liu et al.   HEPATOLOGY

Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies

(2019) Yi-Zhou Jiang et al.   CANCER CELL

Consideration of breast cancer subtype in targeting the androgen receptor

(2019) Clasina M. Venema et al.   PHARMACOLOGY & THERAPEUTICS

Activation of PERK-eIF2α-ATF4 pathway contributes to diabetic hepatotoxicity: Attenuation of ER stress by Morin

(2019) Vivek Kumar Pandey et al.   CELLULAR SIGNALLING

Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells

(2019) Liu et al.   Cancers

Genistein upregulates cyclin D1 and CDK4 expression and promotes the proliferation of ovarian cancer OVCAR-5 cells

(2019) Yali Wang et al.   CLINICA CHIMICA ACTA

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

(2019) Natalia Siwecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

(2019) Shatha AbuHammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PI3K/AKT/mTOR and CDK4/6 Pathways in Endocrine Resistant HR+/HER2− Metastatic Breast Cancer: Biological Mechanisms and New Treatments

(2019) Daniele Presti et al.   Cancers

Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer

(2019) Wei Wen et al.   Cells

YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways

(2019) Qun Chen et al.   BRITISH JOURNAL OF CANCER

Recent treatment progress of triple negative breast cancer

(2019) Yang Chang-Qing et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

PERK Regulates Glioblastoma Sensitivity to ER Stress While Promoting Radiation Resistance

(2018) David YA Dadey et al.   MOLECULAR CANCER RESEARCH

Overexpression of miR-1283 inhibits cell proliferation and invasion of glioma cells by targeting ATF4

(2018) Hao Chen et al.   ONCOLOGY RESEARCH

The Unfolded Protein Response in Breast Cancer

(2018) Eoghan McGrath et al.   Cancers

Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

(2018) Xiaoli Li et al.   OncoTargets and Therapy

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis

(2017) Yuanzhong Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury

(2015) Tomoaki Koga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tanshinone IIA Inhibits HIF-1α and VEGF Expression in Breast Cancer Cells via mTOR/p70S6K/RPS6/4E-BP1 Signaling Pathway

(2015) Guobing Li et al.   PLoS One

Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications

(2014) Jothi Krishnamoorthy et al.   CELL CYCLE

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism-Based Screen for G1/S Checkpoint Activators Identifies a Selective Activator of EIF2AK3/PERK Signalling

(2012) Simon R. Stockwell et al.   PLoS One

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

(2011) Tomasz Rzymski et al.   CELL CYCLE

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM