NAD-capped RNAs – a redox cofactor meets RNA

Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA

(2022) Sunny Sharma et al.   Nature Communications

NAD+-capped RNAs are widespread in rice (Oryza sativa) and spatiotemporally modulated during development

(2022) Haijiao Dong et al.   Science China-Life Sciences

SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts

(2021) Hao Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

(2020) Selom K Doamekpor et al.   NUCLEIC ACIDS RESEARCH

Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs

(2020) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs

(2020) Florian Abele et al.   Biomolecules

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis

(2020) Xiang Yu et al.   DEVELOPMENTAL CELL

Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity

(2019) Aleksandra Kwasnik et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding

(2019) Ewa Grudzien-Nogalska et al.   Nature Chemical Biology

NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis

(2019) Hailei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated

(2019) Yuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arabidopsis DXO1 possesses deNADding and exonuclease activities and its mutation affects defense‐related and photosynthetic gene expression

(2019) Shuying Pan et al.   Journal of Integrative Plant Biology

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms

(2019) Jan Philip Wurm et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The 5′ NAD Cap of RNAIII Modulates Toxin Production in Staphylococcus aureus Isolates

(2019) Hector Gabriel Morales-Filloy et al.   JOURNAL OF BACTERIOLOGY

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs

(2019) Hao Wu et al.   Cell Reports

CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5′ Capping with NAD +

(2018) Irina O. Vvedenskaya et al.   MOLECULAR CELL

Insights into the biogenesis, function, and regulation of ADP-ribosylation

(2018) Michael S Cohen et al.   Nature Chemical Biology

Eukaryotic RNA 5′-End NAD + Capping and DeNADding

(2018) Megerditch Kiledjian   TRENDS IN CELL BIOLOGY

“NAD-capQ” detection and quantitation of NAD caps

(2018) Ewa Grudzien-Nogalska et al.   RNA

Identification, Biosynthesis, and Decapping of NAD-Capped RNAs in B. subtilis

(2018) Jens Frindert et al.   Cell Reports

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs

(2018) Agnieszka Mlynarska-Cieslak et al.   ORGANIC LETTERS

Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

(2018) Jeremy G Bird et al.   eLife

Viral Epitranscriptomics

(2017) Edward M. Kennedy et al.   JOURNAL OF VIROLOGY

Boronate affinity electrophoresis for the purification and analysis of cofactor-modified RNAs

(2017) Gabriele Nübel et al.   METHODS

The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage

(2017) Kelly R. Karch et al.   Molecular BioSystems

Synthesis of 5′-NAD-Capped RNA

(2016) Katharina Höfer et al.   BIOCONJUGATE CHEMISTRY

Structural basis of prokaryotic NAD-RNA decapping by NudC

(2016) Delin Zhang et al.   CELL RESEARCH

Cap-like structures in bacterial RNA and epitranscriptomic modification

(2016) Andres Jäschke et al.   CURRENT OPINION IN MICROBIOLOGY

The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

(2016) Jeremy G. Bird et al.   NATURE

Structure and function of the bacterial decapping enzyme NudC

(2016) Katharina Höfer et al.   Nature Chemical Biology

Capture and sequencing of NAD-capped RNA sequences with NAD captureSeq

(2016) Marie-Luise Winz et al.   Nature Protocols

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of NAD+capped mRNAs inSaccharomyces cerevisiae

(2016) Robert W. Walters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs

(2014) Hana Cahová et al.   NATURE

Processing of snoRNAs as a new source of regulatory non-coding RNAs

(2012) Marina Falaleeva et al.   BIOESSAYS

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Enzymology of RNA cap synthesis

(2010) Agnidipta Ghosh et al.   Wiley Interdisciplinary Reviews-RNA

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38

(2009) Richard Graeff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC/MS analysis of cellular RNA reveals NAD-linked RNA

(2009) Y Grace Chen et al.   Nature Chemical Biology