The role of ILC subsets in cancer

Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

(2022) Aftab Alam et al.   CANCER CELL

Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses

(2022) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Clinical and Translational Significance of Basophils in Patients with Cancer

(2022) Jitesh Chauhan et al.   Cells

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer

(2022) Maxime Meylan et al.   IMMUNITY

ILC1s control leukemia stem cell fate and limit development of AML

(2022) Zhenlong Li et al.   NATURE IMMUNOLOGY

Innate lymphoid cells and cancer

(2022) Nicolas Jacquelot et al.   NATURE IMMUNOLOGY

Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies

(2022) Emily R. Kansler et al.   NATURE IMMUNOLOGY

An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis

(2022) Eric Jou et al.   Science Immunology

Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

(2021) Korneliusz Golebski et al.   IMMUNITY

ILC2-derived IL-9 inhibits colorectal cancer progression by activating CD8+ T cells

(2021) Jie Wan et al.   CANCER LETTERS

Group‐2 Innate Lymphoid Cells Promote Hepatocellular Carcinoma Progression via CXCL2‐Neutrophil Induced Immunosuppression

(2021) Xingyuan Xu et al.   HEPATOLOGY

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions

(2021) Giuseppe Ercolano et al.   Nature Communications

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

(2021) Jeremy Goc et al.   CELL

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

(2021) Nicolas Jacquelot et al.   NATURE IMMUNOLOGY

Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment

(2021) Uriel Y. Moreno-Nieves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

(2021) Laura Ducimetière et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation of innate lymphoid cell subsets infiltrating colorectal carcinoma

(2020) Paolo Carrega et al.   GUT

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

(2020) John Alec Moral et al.   NATURE

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer

(2020) Shuo Wang et al.   CELL RESEARCH

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

(2020) Christoph S. N. Klose et al.   CELL RESEARCH

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

(2020) Anna Rao et al.   Nature Communications

Human NKp44+ Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer

(2020) Atsuyo Ikeda et al.   Cancer Immunology Research

Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma

(2020) Camille Guillerey et al.   IMMUNOLOGY AND CELL BIOLOGY

ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

(2020) Martijn J. Schuijs et al.   NATURE IMMUNOLOGY

Eomes Expression Defines Group 1 Innate Lymphoid Cells During Metastasis in Human and Mouse

(2020) Riva Verma et al.   Frontiers in Immunology

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

(2020) Juan M. Inclan-Rico et al.   NATURE IMMUNOLOGY

Tumor-Infiltrating Natural Killer Cells

(2020) Beatriz Cózar et al.   Cancer Discovery

Innate lymphoid cells: from helper to killer

(2020) Lisette Krabbendam et al.   CURRENT OPINION IN IMMUNOLOGY

NCR− group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development

(2019) Yonghao Liu et al.   EBioMedicine

Antigen-presenting ILC3 regulate T cell–dependent IgA responses to colonic mucosal bacteria

(2019) Felipe Melo-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL23-Producing Human Lung Cancer Cells Promote Tumor Growth via Conversion of Innate Lymphoid Cell 1 (ILC1) into ILC3

(2019) Jaemoon Koh et al.   CLINICAL CANCER RESEARCH

Peripheral Innate Lymphoid Cells Are Increased in First Line Metastatic Colorectal Carcinoma Patients: A Negative Correlation With Th1 Immune Responses

(2019) Romain Loyon et al.   Frontiers in Immunology

Activated innate lymphoid cell populations accumulate in human tumour tissues

(2018) Maryam Salimi et al.   BMC CANCER

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Type 2 Innate Lymphoid Cells Impede IL-33–Mediated Tumor Suppression

(2018) Alan Long et al.   JOURNAL OF IMMUNOLOGY

Human ILC1: To Be or Not to Be

(2017) Jochem H. Bernink et al.   IMMUNITY

ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence

(2017) Mathieu F. Chevalier et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue microenvironment dictates the fate and tumor-suppressive function of type 3 ILCs

(2017) Kathrin Nussbaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

(2017) Sara Trabanelli et al.   Nature Communications

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

(2017) Medya Mara Shikhagaie et al.   Cell Reports

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

(2016) Iris de Weerdt et al.   HAEMATOLOGICA

Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis

(2016) Sihua Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NK cells and type 1 innate lymphoid cells: partners in host defense

(2016) Hergen Spits et al.   NATURE IMMUNOLOGY

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia

(2016) Iris de Weerdt et al.   HAEMATOLOGICA

ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity

(2015) Hadi Maazi et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

(2015) Paolo Carrega et al.   Nature Communications

Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

(2014) N. von Burg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of ILC2s in Peripheral Blood Might Contribute to Immunosuppressive Microenvironment in Patients with Gastric Cancer

(2014) Qingli Bie et al.   Journal of Immunology Research

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE