Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway

Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation

(2021) Hongyu Chen et al.   Oxidative Medicine and Cellular Longevity

Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

(2021) Xiaobin Luo et al.   Drug Design Development and Therapy

Effects of Apigenin Treatment on Random Skin Flap Survival in Rats

(2021) Xinyi Ma et al.   Frontiers in Pharmacology

Apigenin enhances viability of random skin flaps by activating autophagy

(2021) Dingchao Zhu et al.   PHYTOTHERAPY RESEARCH

Pre-clinical Evidence: Berberine as a Promising Cardioprotective Candidate for Myocardial Ischemia/Reperfusion Injury, a Systematic Review, and Meta-Analysis

(2021) Cong Chen et al.   Frontiers in Cardiovascular Medicine

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis

(2021) Jiazhi Yi et al.   Cell Death Discovery

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

(2020) Hadi Samadian et al.   Scientific Reports

Protective effects of dexmedetomidine on the survival of random flaps

(2020) Miaojie Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Angiogenic and anti-inflammatory properties of azadirachtin A improve random skin flap survival in rats

(2020) Ji-Bing He et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Inhibition of eNOS by L-NAME resulting in rat hind limb developmental defects through PFKFB3 mediated angiogenetic pathway

(2020) Ziqiang Wu et al.   Scientific Reports

Allogenic endothelial progenitor cell transplantation increases flap survival through an upregulation of eNOs and VEGF on venous flap survival in rabbits

(2019) Zeyuan Jin et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

A Systematic Study of Vascular Distribution Characteristics and Axis Design of Various Flap Types

(2019) Chengliang Deng et al.   MEDICAL SCIENCE MONITOR

Investigation of dose-dependent effects of berberine against renal ischemia/reperfusion injury in experimental diabetic rats

(2019) Meltem Kumaş et al.   NEFROLOGIA

Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies

(2019) Dai-Qiang Liu et al.   PHARMACOLOGICAL RESEARCH

Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

(2019) Jiannan Bai et al.   PHYTOMEDICINE

Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling

(2019) Nanding Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury

(2018) Yun Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway

(2018) Jun Yang et al.   NEUROCHEMICAL RESEARCH

Therapeutic effect of berberine on renal ischemia-reperfusion injury in rats and its effect on Bax and Bcl-2

(2018) Haiya Zheng et al.   Experimental and Therapeutic Medicine

Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster

(2018) Antony Anet et al.   JOURNAL OF HAZARDOUS MATERIALS

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism

(2018) Gang Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways

(2018) ChongZhe Pei et al.   PHYTOTHERAPY RESEARCH

Angiogenic and Restorative Abilities of Human Mesenchymal Stem Cells Were Reduced Following Treatment With Serum From Diabetes Mellitus Type 2 Patients

(2017) Jafar Rezaie et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protective Effects Induced by Microwave-Assisted Aqueous Harpagophytum Extract on Rat Cortex Synaptosomes Challenged with Amyloid β-Peptide

(2017) Claudio Ferrante et al.   PHYTOTHERAPY RESEARCH

Improvement of Flap Necrosis in a Rat Random Skin Flap Model by In Vivo Electroporation-Mediated HGF Gene Transfer

(2017) S. Morteza Seyed Jafari et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Topical application of nitrosonifedipine, a novel radical scavenger, ameliorates ischemic skin flap necrosis in a mouse model

(2017) Yutaka Fukunaga et al.   WOUND REPAIR AND REGENERATION

Reoxygenation Reverses Hypoxic Pulmonary Arterial Remodeling by Inducing Smooth Muscle Cell Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Dysfunction

(2017) Jian Chen et al.   Journal of the American Heart Association

Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress

(2016) Guo-long Zhao et al.   ACTA PHARMACOLOGICA SINICA

Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway

(2016) Fei He et al.   ACTA PHARMACOLOGICA SINICA

Electrospun Photocrosslinkable Hydrogel Fibrous Scaffolds for Rapid In Vivo Vascularized Skin Flap Regeneration

(2016) Xiaoming Sun et al.   ADVANCED FUNCTIONAL MATERIALS

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Baicalein protects isoproterenol induced myocardial ischemic injury in male Wistar rats by mitigating oxidative stress and inflammation

(2016) Mukesh Kumar et al.   INFLAMMATION RESEARCH

Thioredoxin Protects Skin Flaps from Ischemia-Reperfusion Injury

(2016) Zhuming Yin et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Protective Effect of Berberine Pretreatment in Hepatic Ischemia/Reperfusion Injury of Rat

(2015) M. Sheng et al.   TRANSPLANTATION PROCEEDINGS

Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats

(2014) Keke Chen et al.   APOPTOSIS

Berberine protects endothelial progenitor cell from damage of TNF-α via the PI3K/AKT/eNOS signaling pathway

(2014) Min Xiao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4

(2013) Ming Zhang et al.   MEDIATORS OF INFLAMMATION

Interactions of Mesenchymal Stem Cells with Endothelial Cells

(2013) Seyed Mahdi Nassiri et al.   STEM CELLS AND DEVELOPMENT

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans

(2012) Fei Cheng et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Safety evaluation of main alkaloids from Rhizoma Coptidis

(2012) Jun Yi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells

(2012) Xiaodong Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acute and Sustained Effects of Vascular Endothelial Growth Factor on Survival of Flaps and Skin Grafts

(2011) Feng Zhang et al.   ANNALS OF PLASTIC SURGERY

Antioxidant Effects of Propofol on Tourniquet-Induced Ischemia-Reperfusion Injury: An Experimental Study

(2011) Fatih Ozkan et al.   JOURNAL OF SURGICAL RESEARCH

Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease

(2010) Damir Hamamdzic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A single dose of carbon monoxide intraperitoneal administration protects rat intestine from injury induced by lipopolysaccharide

(2010) Shao-Hua Liu et al.   CELL STRESS & CHAPERONES

Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: Focus on Pi3K/AKT/eNOS pathway

(2010) Bert R. Everaert et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A new design of a dorsal flap in the rat to study skin necrosis and its prevention

(2010) Christopher P. Kelly et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

(2010) Hsiu-Chung Ou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

(2009) Yiyi Sun et al.   ANTI-CANCER DRUGS

Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism

(2009) L. Chen et al.   XENOBIOTICA