Metrics other than potency reveal systematic variation in responses to cancer drugs

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data

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Phase I trials of targeted anticancer drugs: a need to refocus

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Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis

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The proliferation rate paradox in antimitotic chemotherapy

(2011) Timothy J. Mitchison   MOLECULAR BIOLOGY OF THE CELL

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Subtype and pathway specific responses to anticancer compounds in breast cancer

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Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance

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Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

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Molecular Target Class Is Predictive of In vitro Response Profile

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mTOR signaling and drug development in cancer

(2010) Janet Dancey   Nature Reviews Clinical Oncology

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

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Predicting new molecular targets for known drugs

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

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Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

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Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

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