Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design

(2016) Xiaofeng Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cholesterol lowering: role in cancer prevention and treatment

(2015) Toshiyuki Murai   BIOLOGICAL CHEMISTRY

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) fromAspergillus fumigatusand Molecular Basis for the Development of Antifungal Drugs

(2015) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

(2015) Galina I. Lepesheva et al.   JOURNAL OF INFECTIOUS DISEASES

Disorders of Cholesterol Metabolism and Their Unanticipated Convergent Mechanisms of Disease

(2014) Frances M. Platt et al.   Annual Review of Genomics and Human Genetics

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

(2014) Aleksandra Pandyra et al.   CANCER RESEARCH

Spectrum of statin hepatotoxicity: Experience of the drug-induced liver injury network

(2014) Mark W. Russo et al.   HEPATOLOGY

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

(2014) Laura Friggeri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Statins and skeletal muscles toxicity: From clinical trials to everyday practice

(2014) Giuseppe Danilo Norata et al.   PHARMACOLOGICAL RESEARCH

Statins in neurological disorders: An overview and update

(2014) Anna Maria Malfitano et al.   PHARMACOLOGICAL RESEARCH

Muscle- and skeletal-related side-effects of statins: tip of the iceberg?

(2014) Johann Auer et al.   European Journal of Preventive Cardiology

Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial

(2013) Olöf Bjarnadottir et al.   BREAST CANCER RESEARCH AND TREATMENT

Randomized double-blinded, placebo-controlled phase II trial of simvastatin and gemcitabine in advanced pancreatic cancer patients

(2013) Jung Yong Hong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Complexes ofTrypanosoma cruziSterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

(2013) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metrics other than potency reveal systematic variation in responses to cancer drugs

(2013) Mohammad Fallahi-Sichani et al.   Nature Chemical Biology

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Cholesterol and prostate cancer

(2012) Kristine Pelton et al.   CURRENT OPINION IN PHARMACOLOGY

Statins Personalized

(2012) H. Robert Superko et al.   MEDICAL CLINICS OF NORTH AMERICA

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

(2012) Tatiana Y. Hargrove et al.   International Journal for Parasitology-Drugs and Drug Resistance

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

A Randomized Phase II Study of Gefitinib Plus Simvastatin Versus Gefitinib Alone in Previously Treated Patients with Advanced Non–Small Cell Lung Cancer

(2011) Ji-Youn Han et al.   CLINICAL CANCER RESEARCH

Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis

(2011) Galina I. Lepesheva et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Managing the underestimated risk of statin-associated myopathy

(2011) Loukianos S. Rallidis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) fromLeishmania infantum

(2011) Tatiana Y. Hargrove et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hints That Statins Reduce Colon Cancer Risk Finally Being Put to the Test

(2011) K. Hede   JNCI-Journal of the National Cancer Institute

Prospects of Statins in Parkinson Disease

(2011) Avik Roy et al.   NEUROSCIENTIST

Structural basis for conservation in the CYP51 family

(2010) Galina I. Lepesheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases

(2010) Heather A. Hirsch et al.   CANCER CELL

Statin use and cancer risk: a comprehensive review

(2010) Denise M Boudreau et al.   Expert Opinion On Drug Safety

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human PathogenTrypanosoma cruzi

(2010) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Conazoles

(2010) Jan Heeres et al.   MOLECULES

Statin-Associated Muscle-Related Adverse Effects: A Case Series of 354 Patients

(2010) Stephanie Cham et al.   PHARMACOTHERAPY

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

(2009) James M. Kraus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Association between plasma cholesterol and prostate cancer in the PSA era

(2008) Elizabeth A. Platz et al.   INTERNATIONAL JOURNAL OF CANCER

Statins induce lethal effects in acute myeloblastic leukemia cells within 72 hours

(2008) Lillian P. Burke et al.   LEUKEMIA & LYMPHOMA