期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 99, 期 6, 页码 883-892出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.2MR1015-477R
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资金
- European Community's Seventh Framework Program [HEALTH-F4-2011-281608]
- Ministero dell'Istruzione dell'Universita e della Ricerca [2009JP9WTS_002, RBFR08CW8G]
- Italian Association for Cancer Research (AIRC)
Chemokines modulate immune responses through their ability to orchestrate the migration of target cells. Chemokines directly induce cell migration through a distinct set of 7 transmembrane domain G protein-coupled receptors but are also recognized by a small subfamily of atypical chemokine receptors, characterized by their inability to support chemotactic activity. Atypical chemokine receptors are now emerging as crucial regulatory components of chemokine networks in a wide range of physiologic and pathologic contexts. Although a new nomenclature has been approved recently to reflect their functional distinction from their conventional counterparts, a systematic view of this subfamily is still missing. This review discusses their biochemical and immunologic properties to identify potential unifying themes in this emerging family.
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