Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers

 -arrestin-1 mediates the TCR-triggered re-routing of distal receptors to the immunological synapse by a PKC-mediated mechanism

(2014) E. Fernandez-Arenas et al.   EMBO JOURNAL

Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system

(2014) Jessica L. Williams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Rapid Accumulation of Epidermal CCL27 in Skin-Draining Lymph Nodes following Topical Application of a Contact Sensitizer Recruits CCR10-Expressing T Cells

(2014) V. Huang et al.   JOURNAL OF IMMUNOLOGY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis

(2013) Kosuke Tanegashima et al.   FEBS LETTERS

CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus

(2013) Clara Schultheiß et al.   HIPPOCAMPUS

The CXCL12/CXCR4/CXCR7 ligand-receptor system regulates neuro-glio-vascular interactions and vessel growth during human brain development

(2013) Daniela Virgintino et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Drainage of Cells and Soluble Antigen from the CNS to Regional Lymph Nodes

(2013) Jon D. Laman et al.   Journal of Neuroimmune Pharmacology

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Microglia Are Essential to Masculinization of Brain and Behavior

(2013) K. M. Lenz et al.   JOURNAL OF NEUROSCIENCE

Brain microglia: watchdogs with pedigree

(2013) Harald Neumann et al.   NATURE NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Current status of chemokines in the adult CNS

(2013) Annabelle Réaux-Le Goazigo et al.   PROGRESS IN NEUROBIOLOGY

The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76

(2013) X. Smith et al.   Science Signaling

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

(2012) Jigisha R. Patel et al.   ACTA NEUROPATHOLOGICA

Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier

(2012) Yasunobu Arima et al.   CELL

Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway

(2012) Pappachan E. Kolattukudy et al.   CIRCULATION RESEARCH

Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke

(2012) Yongting Wang et al.   CURRENT DRUG TARGETS

 -arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation

(2012) H. Mahabaleshwar et al.   DEVELOPMENT

Wnt Signaling Regulates Intermediate Precursor Production in the Postnatal Dentate Gyrus by Regulating Cxcr4 Expression

(2012) Youngshik Choe et al.   DEVELOPMENTAL NEUROSCIENCE

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

(2012) Ann M Stowe et al.   Journal of Neuroinflammation

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

CXCL12 Enhances Human Neural Progenitor Cell Survival Through a CXCR7- and CXCR4-Mediated Endocytotic Signaling Pathway

(2012) Bing Zhu et al.   STEM CELLS

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

(2011) Owain W. Howell et al.   BRAIN

CCR6 as a mediator of immunity in the lung and gut

(2011) Toshihiro Ito et al.   EXPERIMENTAL CELL RESEARCH

CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination

(2011) Kevin S. Carbajal et al.   GLIA

The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells

(2011) Veysel Ödemis et al.   GLIA

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

(2011) Lillian Cruz-Orengo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal Cell-Derived Factor-1 Signaling via the CXCR4-TCR Heterodimer Requires Phospholipase C- 3 and Phospholipase C- 1 for Distinct Cellular Responses

(2011) K. N. Kremer et al.   JOURNAL OF IMMUNOLOGY

The chemokine BRAK/CXCL14 regulates synaptic transmission in the adult mouse dentate gyrus stem cell niche

(2011) Ghazal Banisadr et al.   JOURNAL OF NEUROCHEMISTRY

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

(2011) Andrej Kovac et al.   Journal of Neuroinflammation

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

(2010) Carolin Prodinger et al.   ACTA NEUROPATHOLOGICA

Adult SVZ Lineage Cells Home to and Leave the Vascular Niche via Differential Responses to SDF1/CXCR4 Signaling

(2010) Erzsebet Kokovay et al.   Cell Stem Cell

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Circulating Dendritic Cells in Melanoma: Role of CCR6 in Plasmacytoid Dendritic Cell Recruitment to the Tumor

(2010) Julie Charles et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Expression and regulation in the brain of the chemokine CCL27 gene locus

(2010) Chad Gunsolly et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression and function of CXCR7 in the mouse forebrain

(2010) Marie-Catherine Tiveron et al.   JOURNAL OF NEUROIMMUNOLOGY

The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases

(2010) Grégory Conductier et al.   JOURNAL OF NEUROIMMUNOLOGY

Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice

(2010) Holly R. Chinnery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dual Roles for Perivascular Macrophages in Immune-to-Brain Signaling

(2010) Jordi Serrats et al.   NEURON

Immunohistochemical localization of chemokine CXCL14 in rat hypothalamic neurons

(2010) Toshiharu Yamamoto et al.   NEUROSCIENCE LETTERS

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11

(2010) Ulrike Naumann et al.   PLoS One

Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis

(2010) K. S. Carbajal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

(2010) J. R. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Overexpression of Platelet-Derived Growth Factor-BB Increases Tumor Pericyte Content via Stromal-Derived Factor-1 /CXCR4 Axis

(2009) N. Song et al.   CANCER RESEARCH

Intranasal delivery of cells to the brain

(2009) Lusine Danielyan et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice

(2009) Matthias Schilling et al.   EXPERIMENTAL NEUROLOGY

Pertussis Toxin Signals through the TCR to Initiate Cross-Desensitization of the Chemokine Receptor CXCR4

(2009) O. D. Schneider et al.   JOURNAL OF IMMUNOLOGY

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus

(2009) S. Ma et al.   LEARNING & MEMORY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

(2009) Adam D. Bachstetter et al.   NEUROBIOLOGY OF AGING

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny

(2009) E. Pastrana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

(2008) Bijan Boldajipour et al.   CELL

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Neural Stem Cells Confer Unique Pinwheel Architecture to the Ventricular Surface in Neurogenic Regions of the Adult Brain

(2008) Zaman Mirzadeh et al.   Cell Stem Cell

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation

(2008) Patricia Hermand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain

(2008) Bastian Schönemeier et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain

(2008) Bastian Schönemeier et al.   JOURNAL OF NEUROIMMUNOLOGY

The Chemokine Stromal Cell-Derived Factor-1 Regulates GABAergic Inputs to Neural Progenitors in the Postnatal Dentate Gyrus

(2008) B. J. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

Distinct Cellular Patterns of Upregulated Chemokine Expression Supporting a Prominent Inflammatory Role in Traumatic Brain Injury

(2008) Charlotte Israelsson et al.   JOURNAL OF NEUROTRAUMA

Early age-related changes in adult hippocampal neurogenesis in C57 mice

(2008) Nada M.-B. Ben Abdallah et al.   NEUROBIOLOGY OF AGING

IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress

(2008) J. W. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA