Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD

Larger dentate gyrus volume as predisposing resilience factor for the development of trauma-related symptoms

(2021) Saskia B. J. Koch et al.   NEUROPSYCHOPHARMACOLOGY

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

(2021) Ling-Xiao Shao et al.   NEURON

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

(2021) Írisz Szabó et al.   NEUROPHARMACOLOGY

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression

(2020) Meghan Hibicke et al.   ACS Chemical Neuroscience

CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons

(2020) Eli-Eelika Esvald et al.   JOURNAL OF NEUROSCIENCE

N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats

(2020) Sándor Nardai et al.   EXPERIMENTAL NEUROLOGY

Elucidating Anti‐Inflammatory SAR at the 5‐HT 2A Receptor

(2020) Gerald Bernard Billac et al.   FASEB JOURNAL

One Dose of Psilocybin in Late Adolescence Mitigates Deleterious Effects of Developmental Stress on Cognition and Behavioral Despair in Adult Female Rats

(2020) Meghan Hibicke et al.   FASEB JOURNAL

Reviewing the Potential of Psychedelics for the Treatment of PTSD

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CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice

(2020) Jia Li et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

(2020) Nicole Leite Galvão-Coelho et al.   JOURNAL OF PSYCHOPHARMACOLOGY

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

(2020) Jose A. Morales-Garcia et al.   Translational Psychiatry

Transcriptomic organization of the human brain in post-traumatic stress disorder

(2020) Matthew J. Girgenti et al.   NATURE NEUROSCIENCE

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

(2019) Amber N. Ziegler et al.   Stem Cell Reports

Biased Receptor Signaling in Drug Discovery

(2019) Terry Kenakin   PHARMACOLOGICAL REVIEWS

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

(2019) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

HPA axis regulation and stress response is subject to intergenerational modification by paternal trauma and stress

(2019) Vicky Batchelor et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

(2019) Romain Nardou et al.   NATURE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

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5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model

(2019) Thomas W. Flanagan et al.   LIFE SCIENCES

Activation of 5-HT2 Receptors Reduces Inflammation in Vascular Tissue and Cholesterol Levels in High-Fat Diet-Fed Apolipoprotein E Knockout Mice

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Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: Linking exposure to neurodevelopmental alterations and threat anticipation

(2019) Aleksandra Lecei et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression

(2018) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

(2018) Mark W. Logue et al.   BIOLOGICAL PSYCHIATRY

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

(2018) Fernanda Palhano-Fontes et al.   PSYCHOLOGICAL MEDICINE

Psychedelics Promote Structural and Functional Neural Plasticity

(2018) Calvin Ly et al.   Cell Reports

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

(2018) Antonio Inserra   Frontiers in Pharmacology

Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT)

(2018) Lindsay P. Cameron et al.   ACS Chemical Neuroscience

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review

(2018) M. Pardo et al.   NEUROSCIENCE RESEARCH

Cognitive Flexibility Predicts PTSD Symptoms: Observational and Interventional Studies

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Automated measurement of hippocampal subfields in PTSD: Evidence for smaller dentate gyrus volume

(2017) Jasmeet P. Hayes et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy

(2017) Olalekan M. Ogundele et al.   NEUROSCIENCE

Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD

(2017) Mark W. Miller et al.   HARVARD REVIEW OF PSYCHIATRY

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

(2017) Jose A. Morales-García et al.   Scientific Reports

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

(2017) Vanja Dakic et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Ayahuasca: Pharmacology, neuroscience and therapeutic potential

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Psychedelics as Medicines: An Emerging New Paradigm

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Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression

(2016) Rafael Faria Sanches et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The association between post-traumatic stress disorder and lifetime DSM-5 psychiatric disorders among veterans: Data from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

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Context Processing and the Neurobiology of Post-Traumatic Stress Disorder

(2016) Israel Liberzon et al.   NEURON

An active inference theory of allostasis and interoception in depression

(2016) Lisa Feldman Barrett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The epidemiology of DSM-5 posttraumatic stress disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III

(2016) Risë B. Goldstein et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics

(2016) Joanne Ryan et al.   Epigenomics

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

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The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

(2016) Attila Szabo et al.   Frontiers in Neuroscience

Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress

(2015) Yan-Wei Luo et al.   NEUROPHARMACOLOGY

How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets

(2015) Lucia Peixoto et al.   NUCLEIC ACIDS RESEARCH

A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex

(2015) Mark W. Miller et al.   PSYCHONEUROENDOCRINOLOGY

Exploring the therapeutic potential of Ayahuasca: acute intake increases mindfulness-related capacities

(2015) Joaquim Soler et al.   PSYCHOPHARMACOLOGY

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

(2015) Flávia de L. Osório et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

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(2015) M. Uhlen et al.   SCIENCE

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(2015) Rachel Yehuda et al.   Nature Reviews Disease Primers

Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder

(2014) C. Brad Wilson et al.   BEHAVIOURAL BRAIN RESEARCH

Ox-LDL Upregulates CRP Expression Through the IGF2 Pathway in THP-1 Macrophages

(2014) Shu-Fen Li et al.   INFLAMMATION

Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear Renewal

(2014) S. N. Garfinkel et al.   JOURNAL OF NEUROSCIENCE

Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis

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(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

Predator Exposure/Psychosocial Stress Animal Model of Post-Traumatic Stress Disorder Modulates Neurotransmitters in the Rat Hippocampus and Prefrontal Cortex

(2014) C. Brad Wilson et al.   PLoS One

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

(2014) Aaron Janowsky et al.   PSYCHOPHARMACOLOGY

Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder

(2014) C. Brad Wilson et al.   Frontiers in Behavioral Neuroscience

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity

(2013) Ede Frecska et al.   JOURNAL OF NEURAL TRANSMISSION

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Inflammation and Oxidative Stress Are Elevated in the Brain, Blood, and Adrenal Glands during the Progression of Post-Traumatic Stress Disorder in a Predator Exposure Animal Model

(2013) C. Brad Wilson et al.   PLoS One

Sex-specific impairment of spatial memory in rats following a reminder of predator stress

(2013) Hanna M. Burke et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Placental programming of anxiety in adulthood revealed by Igf2-null models

(2013) Mikael Allan Mikaelsson et al.   Nature Communications

Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca

(2012) Jordi Riba et al.   Drug Testing and Analysis

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(2012) Roger K. Pitman et al.   NATURE REVIEWS NEUROSCIENCE

Psychosocial animal model of PTSD produces a long-lasting traumatic memory, an increase in general anxiety and PTSD-like glucocorticoid abnormalities

(2012) Phillip R. Zoladz et al.   PSYCHONEUROENDOCRINOLOGY

Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions

(2011) Hong-Wu Shen et al.   CURRENT DRUG METABOLISM

A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories

(2011) Roberto Carlos Agis-Balboa et al.   EMBO JOURNAL

Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia

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Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca

(2011) Rafael G. dos Santos et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

(2011) Tania L. Roth et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Pharmacology of ayahuasca administered in two repeated doses

(2011) Rafael G. dos Santos et al.   PSYCHOPHARMACOLOGY

Risk of Diabetes in U.S. Military Service Members in Relation to Combat Deployment and Mental Health

(2010) E. J. Boyko et al.   DIABETES CARE

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury

(2010) Kenji Dohi et al.   Journal of Neuroinflammation

Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a  -Arrestin2/Src/Akt Signaling Complex In Vivo

(2010) C. L. Schmid et al.   JOURNAL OF NEUROSCIENCE

The sigma-1 receptor chaperone as an inter-organelle signaling modulator

(2010) Tsung-Ping Su et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

(2009) D. Fontanilla et al.   SCIENCE

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

(2009) T.-P. Su et al.   Science Signaling

TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction

(2008) Nithya Mariappan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy

(2008) Srinivas Sriramula et al.   HYPERTENSION

GABRG1 and GABRA2 as Independent Predictors for Alcoholism in Two Populations

(2008) Mary-Anne Enoch et al.   NEUROPSYCHOPHARMACOLOGY

Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder

(2008) Phillip R. Zoladz et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS