Ketamine rapidly enhances glutamate-evoked dendritic spinogenesis in medial prefrontal cortex through dopaminergic mechanisms

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

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Ketamine: A Paradigm Shift for Depression Research and Treatment

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Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class

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Lower synaptic density is associated with depression severity and network alterations

(2019) Sophie E. Holmes et al.   Nature Communications

NMDAR-independent, cAMP-dependent antidepressant actions of ketamine

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Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression

(2018) Ella J. Daly et al.   JAMA Psychiatry

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

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Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli

(2018) Caitlin M. Vander Weele et al.   NATURE

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

(2018) Johannes W. de Jong et al.   NEURON

Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination

(2018) Lhotse Hei Lui Ng et al.   Translational Psychiatry

Dopamine System Dysregulation in Major Depressive Disorders

(2017) Pauline Belujon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

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Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

(2017) Marisela Morales et al.   NATURE REVIEWS NEUROSCIENCE

Dendritic Actin Cytoskeleton: Structure, Functions, and Regulations

(2017) Anja Konietzny et al.   Frontiers in Cellular Neuroscience

Sex Differences in Effects of Ketamine on Behavior, Spine Density, and Synaptic Proteins in Socially Isolated Rats

(2016) Ambalika Sarkar et al.   BIOLOGICAL PSYCHIATRY

Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy

(2016) Marko A. Peltoniemi et al.   CLINICAL PHARMACOKINETICS

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

(2016) Danielle M. Gerhard et al.   DRUG DISCOVERY TODAY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

(2016) Taku Nagai et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Reward Processing and Risk for Depression Across Development

(2016) Katherine R. Luking et al.   TRENDS IN COGNITIVE SCIENCES

Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases

(2016) Kevin M. Woolfrey et al.   NEURAL PLASTICITY

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

(2015) Chadi G. Abdallah et al.   Annual Review of Medicine

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease

(2015) Lili Guo et al.   NATURE NEUROSCIENCE

Pleasure Systems in the Brain

(2015) Kent C. Berridge et al.   NEURON

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

(2015) Manabu Fuchikami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromodulation of excitatory synaptogenesis in striatal development

(2015) Yevgenia Kozorovitskiy et al.   eLife

Restoring Mood Balance in Depression: Ketamine Reverses Deficit in Dopamine-Dependent Synaptic Plasticity

(2014) Pauline Belujon et al.   BIOLOGICAL PSYCHIATRY

Reward processing by the lateral habenula in normal and depressive behaviors

(2014) Christophe D Proulx et al.   NATURE NEUROSCIENCE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

(2014) Tevye J. Stachniak et al.   NEURON

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

(2014) A. K. Friedman et al.   SCIENCE

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder

(2014) Adriana Feder et al.   JAMA Psychiatry

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Reward and aversion in a heterogeneous midbrain dopamine system

(2013) Stephan Lammel et al.   NEUROPHARMACOLOGY

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

Reciprocal regulation of PKA and Rac signaling

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Developmental changes in human dopamine neurotransmission: cortical receptors and terminators

(2012) Debora A Rothmond et al.   BMC NEUROSCIENCE

Aging-Related Increases in Behavioral Variability: Relations to Losses of Dopamine D1 Receptors

(2012) S. W. S. MacDonald et al.   JOURNAL OF NEUROSCIENCE

A CANDLE for a deeper in vivo insight

(2012) Pierrick Coupé et al.   MEDICAL IMAGE ANALYSIS

Recurrent network activity drives striatal synaptogenesis

(2012) Yevgenia Kozorovitskiy et al.   NATURE

Dopamine neurons modulate neural encoding and expression of depression-related behaviour

(2012) Kay M. Tye et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

(2012) Nicolas X. Tritsch et al.   NEURON

Neurochemical and molecular characterization of ketamine-induced experimental psychosis model in mice

(2012) Manavi Chatterjee et al.   NEUROPHARMACOLOGY

Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors

(2012) Caroline Fasano et al.   NEUROPHARMACOLOGY

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Glutamate induces de novo growth of functional spines in developing cortex

(2011) Hyung-Bae Kwon et al.   NATURE

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Changes in Cortical Plasticity Across the Lifespan

(2011) Catarina Freitas et al.   Frontiers in Aging Neuroscience

Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Dopaminergic modulation of cognition across the life span

(2010) Shu-Chen Li et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment

(2009) Dustin Wahlstrom et al.   BRAIN AND COGNITION

Quantitative Analysis of the Expression of Dopamine D1 and D2 Receptors in Pyramidal and GABAergic Neurons of the Rat Prefrontal Cortex

(2008) N. Santana et al.   CEREBRAL CORTEX

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY