Genetics of circadian rhythms and sleep in human health and disease

Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial

(2022) Marta Garaulet et al.   DIABETES CARE

Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities

(2021) Jeanne F Duffy et al.   SLEEP

Genetic determinants of daytime napping and effects on cardiometabolic health

(2021) Hassan S. Dashti et al.   Nature Communications

Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

(2021) Heming Wang et al.   MOLECULAR PSYCHIATRY

Genetics of Sleep and Insights into Its Relationship with Obesity

(2021) Hassan S. Dashti et al.   Annual Review of Nutrition

Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health

(2021) Jessica O’Loughlin et al.   MOLECULAR PSYCHIATRY

From variant to function in human disease genetics

(2021) Tuuli Lappalainen et al.   SCIENCE

Discovery and implications of polygenicity of common diseases

(2021) Peter M. Visscher et al.   SCIENCE

Genetically Proxied Diurnal Preference, Sleep Timing, and Risk of Major Depressive Disorder

(2021) Iyas Daghlas et al.   JAMA Psychiatry

The Genetics of Sleep Disorders in Children: A Narrative Review

(2021) Greta Mainieri et al.   Brain Sciences

Shared genetic liability and causal effects between major depressive disorder and insomnia

(2021) Ancha Baranova et al.   HUMAN MOLECULAR GENETICS

Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

(2020) Marta Garaulet et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank

(2020) Adrián I. Campos et al.   Nature Communications

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Narcolepsy type 1: what have we learned from genetics?

(2020) Hanna M Ollila   SLEEP

SKOR1 has a transcriptional regulatory role on genes involved in pathways related to restless legs syndrome

(2020) Faezeh Sarayloo et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transcriptome-wide association study for restless legs syndrome identifies new susceptibility genes

(2020) Fulya Akçimen et al.   Communications Biology

Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders

(2020) Yue Leng et al.   ANNALS OF NEUROLOGY

Orexin cell transplant reduces behavioral arrest severity in narcoleptic mice

(2020) Ana Clementina Equihua-Benítez et al.   BRAIN RESEARCH

Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait

(2020) Guangsen Shi et al.   CURRENT BIOLOGY

Fxr1 regulates sleep and synaptic homeostasis

(2020) Jivan Khlghatyan et al.   EMBO JOURNAL

Delayed sleep–wake phase disorder in young adults: prevalence and correlates from a national survey of Norwegian university students

(2020) Børge Sivertsen et al.   SLEEP MEDICINE

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

(2020) Satu Strausz et al.   EUROPEAN RESPIRATORY JOURNAL

Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster

(2020) Shailesh Kumar et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

(2019) Hassan S. Dashti et al.   Nature Communications

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

(2019) Samuel E. Jones et al.   Nature Communications

Neurochemical Features Of Idiopathic Restless Legs Syndrome

(2019) Félix Javier Jiménez-Jiménez et al.   SLEEP MEDICINE REVIEWS

Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population

(2019) Takeshi Nishiyama et al.   SLEEP

Biological and clinical insights from genetics of insomnia symptoms

(2019) Jacqueline M. Lane et al.   NATURE GENETICS

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

(2019) Philip R. Jansen et al.   NATURE GENETICS

Genetics of Circadian Rhythms

(2019) Martha Hotz Vitaterna et al.   NEUROLOGIC CLINICS

TIMELESS mutation alters phase responsiveness and causes advanced sleep phase

(2019) Philip Kurien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TEMPORARY REMOVAL: Resetting the late timing of ‘night owls’ has a positive impact on mental health and performance

(2019) Elise R. Facer-Childs et al.   SLEEP MEDICINE

Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep

(2019) Brian E. Cade et al.   PLoS Genetics

Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study

(2019) Junling Fu et al.   INTERNATIONAL JOURNAL OF OBESITY

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

(2019) Samuel E. Jones et al.   Nature Communications

Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease

(2019) Priti Gros et al.   CLINICS IN GERIATRIC MEDICINE

Sleep Duration and Myocardial Infarction

(2019) Iyas Daghlas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors

(2019) Guangsen Shi et al.   NEURON

Extreme morning chronotypes are often familial and not exceedingly rare: the estimated prevalence of advanced sleep phase, familial advanced sleep phase, and advanced sleep–wake phase disorder in a sleep clinic population

(2019) Brian John Curtis et al.   SLEEP

The relationship between insomnia and complex diseases—insights from genetic data

(2019) Enda M. Byrne   Genome Medicine

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

(2019) Jingjing Liang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults

(2019) Bang Zheng et al.   NEUROLOGY

Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation

(2019) Lijuan Xing et al.   Science Translational Medicine

Impact of Circadian Disruption on Cardiovascular Function and Disease

(2019) Sarah L. Chellappa et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes

(2019) Heming Wang et al.   Nature Communications

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

(2019) Raymond Noordam et al.   Nature Communications

Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling

(2019) Daniel A. Lee et al.   Science Advances

Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants

(2019) Mengyu Fan et al.   EUROPEAN HEART JOURNAL

Genomics of circadian rhythms in health and disease

(2019) Filipa Rijo-Ferreira et al.   Genome Medicine

Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea–related Quantitative Trait Locus in Men

(2018) Han Chen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study

(2018) Jesus Lopez-Minguez et al.   CLINICAL NUTRITION

Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses’ Health Study II

(2018) Céline Vetter et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Using genetic data to strengthen causal inference in observational research

(2018) Jean-Baptiste Pingault et al.   NATURE REVIEWS GENETICS

DEC2 modulates orexin expression and regulates sleep

(2018) Arisa Hirano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian preference and sleep timing from childhood to adolescence in relation to genetic variants from a genome-wide association study

(2018) Ilona Merikanto et al.   SLEEP MEDICINE

Genetics of restless legs syndrome: An update

(2018) Félix J. Jiménez-Jiménez et al.   SLEEP MEDICINE REVIEWS

Sleep disorders and Parkinson disease; lessons from genetics

(2018) Ziv Gan-Or et al.   SLEEP MEDICINE REVIEWS

Comorbidities, treatment, and pathophysiology in restless legs syndrome

(2018) Claudia Trenkwalder et al.   LANCET NEUROLOGY

A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

(2018) Marc D. Ruben et al.   Science Translational Medicine

Reassessing GWAS findings for the shared genetic basis of insomnia and restless legs syndrome

(2018) Maryam El Gewely et al.   SLEEP

Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A Systematic Meta-analysis

(2018) C. Capittini et al.   SLEEP MEDICINE

A systems genetics resource and analysis of sleep regulation in the mouse

(2018) Shanaz Diessler et al.   PLOS BIOLOGY

Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis

(2018) Miriam S. Udler et al.   PLOS MEDICINE

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability

(2018) Amy Ferguson et al.   EBioMedicine

Admixture mapping identifies novel loci for obstructive sleep apnea in hispanic/latino americans

(2018) Heming Wang et al.   HUMAN MOLECULAR GENETICS

Melatonin in type 2 diabetes mellitus and obesity

(2018) Angeliki Karamitri et al.   Nature Reviews Endocrinology

GWAS identifies 14 loci for device-measured physical activity and sleep duration

(2018) Aiden Doherty et al.   Nature Communications

Mendelian Randomization

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

(2017) Barbara Schormair et al.   LANCET NEUROLOGY

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

(2017) Anke R Hammerschlag et al.   NATURE GENETICS

Idiopathic REM sleep behaviour disorder and neurodegeneration — an update

(2017) Birgit Högl et al.   Nature Reviews Neurology

The genetics of obstructive sleep apnoea

(2017) Sutapa Mukherjee et al.   RESPIROLOGY

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals

(2017) Ravi Allada et al.   Cold Spring Harbor Perspectives in Biology

Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status

(2017) Mathias Rask-Andersen et al.   PLoS Genetics

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

(2017) Ludmila Gaspar et al.   eLife

Narcolepsy

(2017) Birgitte R. Kornum et al.   Nature Reviews Disease Primers

Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans

(2016) Brian E. Cade et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

(2016) Tiinamaija Tuomi et al.   Cell Metabolism

Impact of Common Diabetes Risk Variant inMTNR1Bon Sleep, Circadian, and Melatonin Physiology

(2016) Jacqueline M. Lane et al.   DIABETES

Genetic variants in RBFOX3 are associated with sleep latency

(2016) Najaf Amin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses

(2016) Jingjing Liang et al.   GENETIC EPIDEMIOLOGY

Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study

(2016) Janek Spada et al.   JOURNAL OF SLEEP RESEARCH

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

(2016) Jacqueline M Lane et al.   NATURE GENETICS

Circadian physiology of metabolism

(2016) Satchidananda Panda   SCIENCE

Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium

(2016) Marcella Marinelli et al.   SLEEP

GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person

(2016) Youna Hu et al.   Nature Communications

Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

(2016) Jacqueline M. Lane et al.   Nature Communications

Health consequences of shift work and insufficient sleep

(2016) Göran Kecklund et al.   BMJ-British Medical Journal

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

(2016) Samuel E. Jones et al.   PLoS Genetics

Health consequences of shift work and insufficient sleep

(2016) Göran Kecklund et al.   BMJ-British Medical Journal

Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium

(2016) Marcella Marinelli et al.   SLEEP

A Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits

(2015) Shubhroz Gill et al.   Cell Metabolism

Across the consciousness continuum—from unresponsive wakefulness to sleep

(2015) Christine Blume et al.   Frontiers in Human Neuroscience

Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans

(2015) Marta Garaulet et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

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(2015) Jana Drgonova et al.   MOLECULAR MEDICINE

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

A Longitudinal Twin Study of Insomnia Symptoms in Adults

(2015) Mackenzie J. Lind et al.   SLEEP

Insomnia disorder

(2015) Charles M. Morin et al.   Nature Reviews Disease Primers

A Longitudinal Twin Study of Insomnia Symptoms in Adults

(2015) Mackenzie J. Lind et al.   SLEEP

International Classification of Sleep Disorders-Third Edition

(2014) Michael J Sateia   CHEST

Identifying advanced and delayed sleep phase disorders in the general population: A national survey of New Zealand adults

(2014) Sarah-Jane Paine et al.   CHRONOBIOLOGY INTERNATIONAL

A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism

(2014) Sibah Hasan et al.   FASEB JOURNAL

Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

(2014) D. Spieler et al.   GENOME RESEARCH

Polymorphisms in the circadian expressed genesPER3andARNTL2are associated with diurnal preference andGNβ3with sleep measures

(2014) Michael J. Parsons et al.   JOURNAL OF SLEEP RESEARCH

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

(2014) D J Gottlieb et al.   MOLECULAR PSYCHIATRY

Guidelines for investigating causality of sequence variants in human disease

(2014) D. G. MacArthur et al.   NATURE

Sleep Health: Can We Define It? Does It Matter?

(2014) Daniel J. Buysse   SLEEP

A Novel BHLHE41 Variant is Associated with Short Sleep and Resistance to Sleep Deprivation in Humans

(2014) Renata Pellegrino et al.   SLEEP

Altered Brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis–Ekbom Disease)

(2014) Christopher J. Earley et al.   SLEEP MEDICINE

Replication of Genome-Wide association studies (GWAS) loci for sleep in the British G1219 cohort

(2013) Michael J. Parsons et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genome-wide association study of sleep in Drosophila melanogaster

(2013) Susan T Harbison et al.   BMC GENOMICS

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

(2013) C. S. Moller-Levet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic

(2013) Fang Han et al.   PLoS Genetics

ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy

(2013) Juliette Faraco et al.   PLoS Genetics

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Sleep Duration and Body Mass Index in Twins: A Gene-Environment Interaction

(2012) Nathaniel F. Watson et al.   SLEEP

HLA-DQ association and allele competition in Chinese narcolepsy

(2012) F. Han et al.   TISSUE ANTIGENS

Genetic and Metabolic Characterization of Insomnia

(2011) Hyo-Jeong Ban et al.   PLoS One

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

(2010) Hyun Hor et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

(2009) T. Sparso et al.   DIABETES

The genetic and molecular regulation of sleep: from fruit flies to humans

(2009) Chiara Cirelli   NATURE REVIEWS NEUROSCIENCE

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

(2009) Y. He et al.   SCIENCE

The electroencephalographic fingerprint of sleep is genetically determined: A twin study

(2008) Luigi De Gennaro et al.   ANNALS OF NEUROLOGY

Heritability of Sleep Electroencephalogram

(2008) Urte Ambrosius et al.   BIOLOGICAL PSYCHIATRY

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

(2008) Vladyslav V Vyazovskiy et al.   NATURE NEUROSCIENCE

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS